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公开(公告)号：EP2261662B1
公开(公告)日：2014-01-22
申请号：EP09007701.7
申请日：2009-06-10
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , Y10T436/143333
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公开(公告)号：EP2542286A2
公开(公告)日：2013-01-09
申请号：EP11704937.9
申请日：2011-02-18
发明人： RÜLLER, Stephan , GREVE, Susanne
CPC分类号： A61M16/00 , A61M16/0069 , A61M16/024 , A61M16/201 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039
摘要： The present invention relates to a method for the ventilation of a living being (3), the respiration airflow (v) flowing into the living being (3) and out of the living being (3) being detected, it being ascertained from the detected respiration airflow (v) whether an inhalation phase or an exhalation phase is present, and the air pressure (p) in a respiratory organ of the living being (3) being regulated, characterized in that, upon recognition of an inhalation phase, the air pressure (p) in the respiratory organ is raised at the beginning of the inhalation phase and lowered again with progressing respiration cycle.
摘要翻译： 本发明涉及一种用于通气的方法（3），流入生物体（3）的呼吸气流（v）和被检测到的生物（3）的呼吸气流（v），从检测到的 呼吸气流（v）是否存在吸入阶段或呼气阶段，以及（3）被调节的生物的呼吸器官中的空气压力（p），其特征在于，在识别到吸入阶段后，空气 呼吸器官的压力（p）在吸入阶段开始时升高，并随着呼吸循环的进行而再次下降。
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公开(公告)号：EP2108372A1
公开(公告)日：2009-10-14
申请号：EP08007064.2
申请日：2008-04-09
发明人： Brandenburg, Klaus
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention relates to a peptide of linear, non-cyclic structure consisting of 17 to 21 amino acids, wherein the amino acids in positions 1 to 21, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) W, L or F; (11) K or R; (12) F, Y or C; (13) K or R; (14) G or Q; (15) K or R; (16) F, L or W; (17) F or W; (18) F, L or W; (19) W or F; (20) C or lacking; (21) G or lacking. Further, the invention relates to a nucleic acid molecule encoding the peptide of the invention, an expression vector comprising the nucleic acid molecule of the invention, a host cell which may be grown in cell culture comprising the vector of the invention, and a method of producing the peptide of the invention comprising culturing the host cell of the invention and collecting the peptide produced. Also, the present invention relates to a pharmaceutical composition comprising the peptide of the invention, the peptide produced by the method of the invention, the nucleic acid molecule of the invention, the expression vector of the invention or the host cell of the invention and a kit comprising the peptide of the invention, the peptide produced by the method of the invention, the nucleic acid molecule of the invention, the expression vector of the invention or the host cell of the invention.
摘要翻译： 本发明涉及由17至21个氨基酸组成的线性非环状结构的肽，其中从N末端计数的1至21位的氨基酸如下（1）G，S或缺乏 ; （2）C或缺乏; （3）K或R; （4）K或R; （5）Y或F; （6）K或R; （7）K或R; （8）F，W或L; （9）K或R; （10）W，L或F; （11）K或R; （12）F，Y或C; （13）K或R; （14）G或Q; （15）K或R; （16）F，L或W; （17）F或W; （18）F，L或W; （19）W或F; （20）C或缺乏; （21）G或缺乏。 此外，本发明涉及编码本发明的肽的核酸分子，包含本发明的核酸分子的表达载体，可以在包含本发明的载体的细胞培养物中生长的宿主细胞，以及 制备本发明的肽，其包括培养本发明的宿主细胞并收集所产生的肽。 此外，本发明涉及包含本发明的肽，通过本发明的方法产生的肽，本发明的核酸分子，本发明的表达载体或本发明的宿主细胞的药物组合物和 包含本发明的肽，通过本发明的方法产生的肽，本发明的核酸分子，本发明的表达载体或本发明的宿主细胞的试剂盒。
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