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11.发明授权NOVEL MARKER FOR DETECTION OF BLADDER CANCER AND/OR INFLAMMATORY CONDITIONS OF THE BLADDER 有权用于检测膀胱的膀胱癌和/或炎症状况的新标志
公开(公告)号：EP2638398B1
公开(公告)日：2018-01-24
申请号：EP11846559.0
申请日：2011-11-11
申请人： Pacific Edge Limited
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/566 , G01N33/57407 , G01N2333/7155 , G06F19/20
摘要： This invention relates to the use of human neutrophil marker interleukin 8 receptor B (IL8Rb) for detection of bladder cancer, and more particularly to the use of EL8Rb for discriminating between transitional cell carcinoma of the bladder (TCC) and inflammatory conditions of the bladder.
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公开(公告)号：EP3176270A1
公开(公告)日：2017-06-07
申请号：EP16203301.3
申请日：2008-05-23
IPC分类号： C12Q1/68
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
摘要翻译： 本发明涉及预后标志物和预后特征，以及用于确定患者中癌症预后的组合物和方法，特别是用于黑素瘤。 具体而言，本发明涉及基于标志物和标志物的标志物和基因标志物，用于预测癌症（例如黑素瘤）发展风险的遗传和蛋白质标志物的用途。 在各个方面，本发明提供基于预后癌症标志物，特别是黑素瘤预后标志物的方法，组合物，试剂盒和装置，以辅助癌症的预后和治疗。
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公开(公告)号：EP2158332B1
公开(公告)日：2017-01-18
申请号：EP08766967.7
申请日：2008-05-23
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
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公开(公告)号：EP2430193B1
公开(公告)日：2016-03-09
申请号：EP10775152.1
申请日：2010-05-14
申请人： Pacific Edge Limited
发明人： GUILFORD, Parry John
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , G01N2333/47 , G01N2333/4725 , G06F19/20
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric tumor tissue, and thus can be used as markers for the detection of gastric and other types of cancer. The present invention provides for novel GTMs for the detection of tumors, including gastric tumors, and in particular human zymogen granule protein 16 (ZG16). The GTMs can be used in isolation or together with other known GTMs to provide for novel signatures to be used in the detection of tumors, including gastric tumors.
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公开(公告)号：EP2444505A2
公开(公告)日：2012-04-25
申请号：EP11188984.6
申请日：2005-07-22
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68 , G01N33/574 , C07K14/47
CPC分类号： C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N2800/52
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.
摘要翻译： 肿瘤的早期检测是患有肿瘤（包括膀胱肿瘤）的患者存活的主要决定因素。 BTM或UBTM家族的成员可以高度一致地累积在膀胱肿瘤组织和其他肿瘤组织中，和/或可以累积在患者的尿液中，因此是膀胱和其他类型癌症的标记。 在某些实施方案中，BTM或UBTM可以积聚在尿液中，并且UBTM家族成员的检测可以是有效的诊断方法。 在一些实施方案中，定量PCR方法优于微阵列方法。 在其他实施方案中，多种BTM或UBTM的检测和定量可以增加膀胱癌检测的灵敏度和特异性，并因此提供确定膀胱癌的阶段和类型的方法。 试剂盒提供了实施本发明方法的简单方便的方法。
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16.发明授权
公开(公告)号：EP3071973B1
公开(公告)日：2020-11-04
申请号：EP14863459.5
申请日：2014-11-20
申请人： Pacific Edge Limited
发明人： DALPHIN, Mark , DARLING, David , SUTTIE, James, Miller , KAVALIERIS, Laimonis , O'SULLIVAN, Paul , KUMAR, Satish
IPC分类号： C12Q1/6886
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17.发明授权MEDICAL DECISION SUPPORT SYSTEMS UTILIZING GENE EXPRESSION AND CLINICAL INFORMATION AND METHOD FOR USE 有权系统，以支持医疗决定使用基因表达和临床资料和使用方法
公开(公告)号：EP1534122B1
公开(公告)日：2016-07-20
申请号：EP03788512.6
申请日：2003-08-15
申请人： Pacific Edge Limited
发明人： KASABOV, Nikola, Kirilov , FUTSCHIK, Matthias, Erwin , SULLIVAN, Michael, James , REEVE, Anthony, Edmund
摘要： Embodiments of this invention provide improved medical decision support systems and methods for using such systems to simultaneously consider two or more different types of information along with estimates of accuracies of the information to produce a combined predictor. Such predictors have greater accuracy compared to use of the individual types of information alone. Increased accuracy can increase the likelihood of correct diagnosis and/or evaluation of clinical condition or outcome, and can decrease the frequency of false negative results, including misdiagnosis. Embodiments of medical decision support systems can include EFuNN, Bayesian or other statistical estimators to produce a combined predictor. The systems can be used to extract relationship rules between sets of genes and clinical variables common for patients of a group, thus making a personalized gene-based treatment possible. Such systems are incorporated into computer-based devices and are run using suitable computer programs. Outputs can be directed to hard-copy devices for printing, or can be transmitted remotely to a terminal at a location where a practitioner is interacting with a patient.
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公开(公告)号：EP2305833A3
公开(公告)日：2012-02-01
申请号：EP10185594.8
申请日：2004-07-16
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57446
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
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20.发明公开PROLIFERATION SIGNATURE AND PROGNOSIS FOR GASTROINTESTINAL CANCER 审中-公开PRULIFERATIONSSIGNATUR UND PROGNOSEFÜRMAGEN-DARM-KREBS
公开(公告)号：EP2995690A1
公开(公告)日：2016-03-16
申请号：EP15187435.1
申请日：2008-10-06
申请人： Pacific Edge Limited
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57419 , G01N33/57446 , G01N2800/60
摘要： This invention relates to methods and compositions for determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as gastric or colorectal cancer, based on cell proliferation signatures. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a personalized genomics profile for a cancer patient, among other methods as well as kits and devices for carrying out these methods.
摘要翻译： 本发明涉及用于确定患者癌症预后的方法和组合物，特别是胃肠癌如胃癌或结肠直肠癌。 具体地，本发明涉及基于细胞增殖特征的遗传标记用于预测癌症预后的用途，例如胃癌或结肠直肠癌。 在各个方面，本发明涉及预测癌症患者的长期存活的可能性的方法，确定癌症患者的治疗方案的方法，为癌症患者制备个性化基因组学资料的方法，其中 其他方法以及用于执行这些方法的套件和设备。
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