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33 条记录 (耗时 0.016 秒)

    INHIBITION OF CELL SURFACE PROTEIN DISULFIDE ISOMERASE
    11.
    发明公开
    INHIBITION OF CELL SURFACE PROTEIN DISULFIDE ISOMERASE 失效
    细胞壁二硫键异构酶的抑制

    公开(公告)号：EP0981344A1

    公开(公告)日：2000-03-01

    申请号：EP98921188.3

    申请日：1998-05-14

    申请人： The University of New Mexico

    发明人： ROGELJ, Snezna ,  SKLAR, Larry, A.

    IPC分类号： A61K31/285

    CPC分类号： A61K31/555 ,  A61K31/285 ,  A61K31/42

    摘要： The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule.

    INHIBITORS OF CHOLESTEROL ESTERASE
    12.
    发明公开
    INHIBITORS OF CHOLESTEROL ESTERASE 失效
    胆固醇酯酶抑制剂

    公开(公告)号：EP0975617A1

    公开(公告)日：2000-02-02

    申请号：EP98918098.9

    申请日：1998-04-15

    申请人： The University of New Mexico

    发明人： DECK, Lorraine ,  VANDER JAGT, David, L.

    IPC分类号： C07D307/20 ,  C07D307/88 ,  C07D309/38 ,  C07D311/76 ,  C07D315/00

    CPC分类号： C07D309/38

    摘要： The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholesterolemia through limiting the bioavailability of dietary cholesterol.

    摘要翻译： 本发明提供了作为胆固醇酯酶活性位点抑制剂有效的新型卤代醇内酯。 通过抑制胆固醇酯酶，本发明的抑制剂通过限制膳食胆固醇的生物利用度提供了治疗高胆固醇血症的新方法。

    Multipurpose surgical tool
    15.
    发明公开
    Multipurpose surgical tool 失效
    手术多用途工具。

    公开(公告)号：EP0656193A3

    公开(公告)日：1995-08-30

    申请号：EP95102423.1

    申请日：1991-02-12

    申请人： THE UNIVERSITY OF NEW MEXICO ,  SPINNAKER R & D ASSOCIATES

    发明人： Cushman, Robert, M. ,  Kirsch, Wolf, Mayer ,  Zhu, Yong, Hua

    IPC分类号： A61B17/30 ,  A61B17/32

    CPC分类号： A61B17/30 ,  A61B17/32

    摘要： 1. A tool comprising:
       a body (10) comprising a pair of flexible leaves (12, 14) joined at their forward ends by a bridge (16) having an elongate aperture (22) therein, said leaves also being joined face-to face at their rearward ends, and being normally bowed outward from one another; and
       an elongated collet (40) having a rearward end affixed to the rearward ends of said leaves, and a bifurcated forward end comprising a pair of resiliently flexible tines (44, 46), each tine having thereon a jaw (48) protruding through said aperture, each jaw including an inwardly facing working surface (50) and an outwardly facing oblique cam surface (52) in a position to engage a side of said aperture, so that relative longitudinal movement between the bridge and the jaws, produced by squeezing the leaves together, causes interaction between the sides of the aperture and the cam surfaces to drive the jaws together
       is improved by providing that:
       the tines of the collet lie in a common plane perpendicular to and bisecting both of said leaves, the length of the aperture being aligned with said plane; and
       the two opposed leaves and the bridge are within a blank of sheet material, the aperture being formed within the sheet.

    Method for making palladium and palladium oxide powders by aerosol decomposition
    16.
    发明公开
    Method for making palladium and palladium oxide powders by aerosol decomposition 失效
    Verfahren zur Herstellung von Palladium- und Palladiumoxid-Pulver durch Aerosol-Zersetzung。

    公开(公告)号：EP0591881A1

    公开(公告)日：1994-04-13

    申请号：EP93115959.4

    申请日：1993-10-02

    申请人： E.I. DU PONT DE NEMOURS AND COMPANY ,  THE UNIVERSITY OF NEW MEXICO

    发明人： Kodas, Toivo Tarmo ,  Lyons, Shirley Weaver ,  Glicksman, Howard David

    IPC分类号： B22F9/24

    CPC分类号： B22F9/30

    摘要： A method for the manufacture of finely divided particles of palladium, palladium oxide or mixtures thereof comprising the sequential steps:

    A. Forming an unsaturated solution of thermally decomposable palladium-containing compound in a thermally volatilizable solvent;
    B. Forming an aerosol consisting essentially of finely divided droplets of the solution from step A. dispersed in an inert carrier gas;
    C. Heating the aerosol to an operating temperature above the decomposition temperature of the palladium-containing compound, but below the melting point of palladium metal by which finely divided particles of palladium, palladium oxide or mixtures thereof are formed and densified; and
    D. Separating the particles of palladium, palladium oxide or mixtures thereof from the carrier gas, reaction by-products and solvent volatilization products.

    摘要翻译： 制备钯，氧化钯或其混合物的细碎颗粒的方法，其包括以下顺序步骤：A.在可热挥发的溶剂中形成可热分解的含钯化合物的不饱和溶液; B.形成基本上由分散在惰性载气中的步骤A的溶液的细碎液滴组成的气溶胶; C.将气溶胶加热到高于含钯化合物分解温度但低于钯金属熔点的操作温度，由此形成细小颗粒的钯，氧化钯或其混合物并致密化; 和D.从载气中分离钯，氧化钯或其混合物的颗粒，反应副产物和溶剂挥发产物。

    METHOD FOR PURIFYING HEAT SHOCK PEPTIDES COMPLEXES
    18.
    发明授权
    METHOD FOR PURIFYING HEAT SHOCK PEPTIDES COMPLEXES 有权
    清理方法热激肽复合物

    公开(公告)号：EP1035780B1

    公开(公告)日：2007-02-14

    申请号：EP98961905.1

    申请日：1998-12-04

    申请人： The University of New Mexico

    发明人： WALLEN, Erik, S. ,  MOSELEY, Pope, L.

    IPC分类号： A23J1/00 ,  C12P19/24 ,  C12P21/04 ,  G01N33/53

    CPC分类号： C07K14/4702

    摘要： The present invention provides a method for synthesizing heat shock protein-peptide complexes comprising the steps of: adding a shock protein to a denatured protein matrix to bind the heat shock protein to the denatured protein matrix; and adding a complexing solution comprising a peptide to elute a heat shock protein-peptide complex. The present invention also provides a heat shock protein-peptide complex synthesized by the method of the invention. In addition the present invention provides an apparatus for synthesizing heat shock protein-peptide complexes comprising a heat shock protein complex bound to a denatured protein matrix. The present invention also provides a method for treating an allergic disease in which a heat shock protein-antigen complex is administered to a mammal in an amount sufficient to reduce the susceptibility of the mammal to a Th2 response for the allergic disease. The method of the present invention can be used either to prevent an invididual from having an allergic reaction to an allergic disease or to reduce the effects of an allergic disease in an individual already suffering from the allergic disease.