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11.发明授权PROCESS FOR THE PREPARATION OF PLATELET GROWTH FACTORS EXTRACT FOR WOUND HEALING COMPOSITIONS 失效用于生产SLIDE生长因子筹备工作的提取物用于伤口愈合
公开(公告)号：EP1007061B1
公开(公告)日：2004-02-11
申请号：EP97908091.8
申请日：1997-03-19
IPC分类号： A61K35/14
CPC分类号： A61K38/39 , A61K35/19 , A61K38/18 , A61K38/38 , A61K2300/00
摘要： The present invention relates to a process for the preparation of porcine platelet-extract containing matured growth factors, which comprises the steps of: a) centrifuging whole porcine blood at about 1000 g to about 5000 g to isolate the platelets from the platelet-rich-plasma; b) resuspending the isolated platelets of step a) in Plasma-Lyte A and centrifuging to concentrate the platelets; c) washing the concentrated platelets of step b); d) lyophilizing the washed platelets of step c); whereby causing lysis of the platelets and producing the platelet extract in optimal amount.
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公开(公告)号：EP0784450A1
公开(公告)日：1997-07-23
申请号：EP95931116.0
申请日：1995-09-15
发明人： BRAZEAU, Paul
IPC分类号： A61B17
CPC分类号： A61B17/085 , A61B2017/086
摘要： The present invention relates to a device for closing cutaneous wounds without sutures, which comprises a pair of three-dimensionally flexible strips adopted to be positioned on each side of a wound and formed of a plurality of laterally spaced apart elongated anchoring members extending side-by-side in succession and transversely of the wound and being interconnected in a three-dimensionally flexible manner to follow the lips of an open wound. Each of the anchoring members has on the underside thereof an adhesive surface for adhesion directly or indirectly to the skin of a patient, and includes at an inner end thereof a thread receiving and retaining portion, whereby a thread can be engaged lace-wise through the anchoring members of both strips so as to draw the anchoring members of one strip towards the anchoring members of the other strip in such a way so as to close in a constant tensiometric way the open wound extending between the two strips with the lips of the wound being equidistant along the entire length thereof.
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公开(公告)号：EP4297795A1
公开(公告)日：2024-01-03
申请号：EP22758666.6
申请日：2022-02-24
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公开(公告)号：EP2699591A4
公开(公告)日：2014-05-07
申请号：EP12774217
申请日：2012-04-17
发明人： PERI KRISHNA G , HABI ABDELKRIM
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公开(公告)号：EP2382984A2
公开(公告)日：2011-11-02
申请号：EP11168850.3
申请日：2003-05-29
IPC分类号： A61K38/25
摘要： There is provided a GRF compound or analog thereof for use in improving daytime vigilance and/or cognitive function in a subject.
摘要翻译： 提供了GRF化合物或其类似物用于改善受试者的白天警觉和/或认知功能。
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17.发明公开BIFUNCTIONAL FUSION PROTEINS OF THE ALPHA-MELANOCYTE STIMULATING HORMONE (ALPHA-MSH) AND ATRIAL NATRIURETIC PROTEIN (ANP) AND USES IN HYPERTENSION AND ACUTE KIDNEY INJURY 审中-公开双功能融合蛋白的所述α-黑素细胞刺激素（ALPHA-MSH）和蛋白心房钠尿（ANP）及它们在高压及急性肾损伤
公开(公告)号：EP2173773A4
公开(公告)日：2010-07-07
申请号：EP08783182
申请日：2008-07-04
发明人： PERI KRISHNA , HABI ABDELKRIM
IPC分类号： C07K19/00 , A61K38/22 , A61P9/12 , A61P13/12 , C07K14/575 , C07K14/58 , C07K14/685
CPC分类号： C07K14/575 , C07K14/58 , C07K14/68 , C07K14/685 , C07K2319/00
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18.发明公开BIFUNCTIONAL FUSION PROTEINS OF THE ALPHA-MELANOCYTE STIMULATING HORMONE (ALPHA-MSH) AND ATRIAL NATRIURETIC PROTEIN (ANP) AND USES IN HYPERTENSION AND ACUTE KIDNEY INJURY 审中-公开双功能融合蛋白的所述α-黑素细胞刺激素（ALPHA-MSH）和蛋白心房钠尿（ANP）及它们在高压及急性肾损伤
公开(公告)号：EP2173773A1
公开(公告)日：2010-04-14
申请号：EP08783182.2
申请日：2008-07-04
发明人： PERI, Krishna , HABI, Abdelkrim
IPC分类号： C07K19/00 , A61K38/22 , A61P13/12 , A61P9/12 , C07K14/575 , C07K14/58 , C07K14/685
CPC分类号： C07K14/575 , C07K14/58 , C07K14/68 , C07K14/685 , C07K2319/00
摘要： A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related hormonal activity covalently linked to a second domain having natriuretic peptide related hormonal activity. The bifunctional hormone of the present invention is useful for example for the prevention and/or treatment of renal related diseases or conditions, such as acute renal failure (ARF) or acute kidney injury (AKI).
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公开(公告)号：EP1628676A1
公开(公告)日：2006-03-01
申请号：EP03724755.8
申请日：2003-05-29
摘要： The present invention relates to compositions for improving daytime vigilance and/or cognitive function, for improving a metabolic condition, for improving anabolism in a catabolic condition and for improving and/or reconstituting immune function in a subject, the composition comprising an effective amount of a GRF compound or analog thereof in association with a pharmaceutically acceptable carrier, excipient or diluent.
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20.发明公开PROCESS FOR THE PREPARATION OF PLATELET GROWTH FACTORS EXTRACT FOR WOUND HEALING COMPOSITIONS 失效用于生产SLIDE生长因子筹备工作的提取物用于伤口愈合
公开(公告)号：EP1007061A1
公开(公告)日：2000-06-14
申请号：EP97908091.8
申请日：1997-03-19
IPC分类号： A61K35/14
CPC分类号： A61K38/39 , A61K35/19 , A61K38/18 , A61K38/38 , A61K2300/00
摘要： The present invention relates to a process for the preparation of porcine platelet-extract containing matured growth factors, which comprises the steps of: a) centrifuging whole porcine blood at about 1000 g to about 5000 g to isolate the platelets from the platelet-rich-plasma; b) resuspending the isolated platelets of step a) in Plasma-Lyte A and centrifuging to concentrate the platelets; c) washing the concentrated platelets of step b); d) lyophilizing the washed platelets of step c); whereby causing lysis of the platelets and producing the platelet extract in optimal amount.
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