摘要:
The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.
摘要:
Determining and implementing individualized platelet support regimens (e.g., administering specified platelet numbers; and, schedules for administration or other intervention, in accordance with the requirements assessed for individual patients) by: monitoring platelet clearance kinetics; analyzing the kinetics to determine value(s) proportionally representing both the extent and frequency of vascular injury, and using such value(s) to determine the momentary requirement for maintaining vascular integrity, and constructing a corresponding platelet administration regimen where said regimen preferably provides for the utilization of platelets selected, from a platelet inventory, in accordance with the recipient's molecular “type”. Releasing from an inventory of a platelet inventory system the particular typed or profiled platelet amounts required to satisfy the platelet administration regimen of each patient. Establishing a replenishing inventory of antigen-typed or antigen-profiled platelets or other cells, which are perishable and may be replaced after expiration, where the inventory can be virtual or held across several locations.
摘要:
Compositions and methods for providing one or more platelet-derived hemostatic agents to a treatment site are provided. Compositions and methods may be directed to bandages, carrier materials, and closure devices. Compositions and methods may be directed to treatment of neoplasias, including cancers. The platelet-derived hemostatic agents may include chemotherapeutic agents.
摘要:
The present invention provides a method for producing purified platelets from a culture of megakaryocytes, comprising a first centrifugal separation step of centrifugally separating the culture at a centrifugal force of 150×g to 550×g, and a second centrifugal separation step of centrifugally separating, at a centrifugal force of 600×g to 4000×g, a liquid component recovered in the first centrifugal separation step.
摘要:
An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, comprising separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein R 1 to R 7 , W, X, Y, Z, Ar 1 and n are as defined in the description) to differentiate them into megakaryocytes and/or platelets.
摘要:
The present invention relates to a method for promoting hair growth and preventing hair loss of a patient, a composition therefor, and a method for preparing the composition. More particularly, the method for promoting hair growth and preventing hair loss of a patient is characterized in that a composition containing an effective amount of an active ingredient comprising bFGF is intradermally or subcutaneously administered into a lesion of a patient suffering from hair loss. The method for promoting hair growth and preventing hair loss of a patient, the composition therefor, and the method for preparing the composition of the present invention have the effects that new blood vessels are generated in a lesion to thereby increase the supply of blood, and growth of fiber tissues and tissue regeneration are promoted to thus thicken the skin tissue of a lesion.
摘要:
Methods for forming activated platelet gels using nsPEF's and applying the activated gels to wounds, such as heart tissue after myocardial infarction. The platelets are activated by applying at least one nsPEF with a duration between about 10 picoseconds to 1 microsecond and electrical field strengths between about 10 kV/cm and 350 kV/cm.