公开(公告)号：EP1436865A4

公开(公告)日：2005-12-28

申请号：EP02761727

申请日：2002-09-19

申请人： UNIV ALABAMA RES FOUND

发明人： MIROV SERGEY B ,  FEDEROV VLADIMIR V

IPC分类号： H01S3/16 ,  C30B31/00 ,  C30B31/02 ,  H01S3/06 ,  H01S3/08 ,  H01S3/081 ,  H01S3/094 ,  H01S3/0941 ,  H01S3/1055 ,  H01S3/113

CPC分类号： H01S3/0805 ,  C30B29/48 ,  C30B31/00 ,  C30B31/02 ,  H01S3/0014 ,  H01S3/0604 ,  H01S3/0627 ,  H01S3/08009 ,  H01S3/08086 ,  H01S3/094038 ,  H01S3/094042 ,  H01S3/094046 ,  H01S3/09415 ,  H01S3/1055 ,  H01S3/108 ,  H01S3/113 ,  H01S3/115 ,  H01S3/117 ,  H01S3/162 ,  H01S3/1623 ,  H01S3/1628 ,  H01S2301/04 ,  Y10S438/917

摘要： A method of performing spatial separation of different wavelengths in a single laser cavity includes generating, from a pump radiation source, pump radiations in spatially separate channels and focusing the generated pump radiations in the spatially separate channels towards an active gain medium having amplification spectra. The method also includes emitting from the active gain medium, amplified radiations of the spatially separate channels, each channel of the spatially separate channels representing a corresponding wavelength and focusing the emitted amplified radiations of the spatially separated channels towards an aperture. The method further includes suppressing, at the aperture, an off-axis mode of the amplified radiations of the spatially separate channels, diffracting the amplified radiations of the spatially separate channels received through the aperture to provide diffracted radiations and returning a portion of the diffracted radiations back to the aperture, and collimating the diffracted radiations of the spatially separate channel.

公开(公告)号：EP1181548A4

公开(公告)日：2003-07-23

申请号：EP00921690

申请日：2000-04-05

申请人： UNIV ALABAMA RES FOUND

发明人： DELUCAS LAWRENCE J ,  BRAY TERRY L

IPC分类号： G01N33/68 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  C07K1/14 ,  C30B7/00 ,  C40B40/10 ,  C40B50/08 ,  C40B60/14 ,  G01N25/14 ,  G01N37/00 ,  G01N31/00 ,  G01N33/00

CPC分类号： G01N25/14 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00369 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00693 ,  B01J2219/00707 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L3/5085 ,  B01L2300/041 ,  B01L2300/0819 ,  C30B7/00 ,  C30B29/58 ,  C40B40/10 ,  C40B50/08 ,  C40B60/14

摘要： A method of screening protein crystal growth conditions with picogram to microgram amounts of protein in picoliter or nanoliter volumes is provided. A preferred method comprises a microarray with a plurality of micro-chambers in the microarray. A protein solution is placed into the micro-chambers by an automated dispensing mechanism. The protein crystal growth conditions of each of the micro-chambers is adjusted so that the protein crystal growth conditions in at least two of the micro-chambers differs. Crystallization of the protein solution in the micro-chambers is effected. Protein crystal growth in the micro-chambers is then observed.

摘要翻译： 提供了一种筛选蛋白质晶体生长条件的方法，以皮克微克至微克量的皮升或纳升体积的蛋白质。 优选的方法包括在微阵列中具有多个微腔的微阵列。 通过自动分配机构将蛋白质溶液放入微室中。 调整每个微腔室的蛋白质晶体生长条件，使得至少两个微腔室中的蛋白质晶体生长条件不同。 蛋白质溶液在微腔中结晶。 然后观察微室中的蛋白质晶体生长。