公开(公告)号：EP1450775B1

公开(公告)日：2008-03-12

申请号：EP02775081.9

申请日：2002-09-20

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/506 ,  A61P31/04

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/015 ,  A61K31/095 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/498 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  G01N33/5047 ,  G01N33/56911 ,  G01N2333/70596 ,  Y02A50/473 ,  Y02A50/481 ,  A61K2300/00

摘要： The present invention relates to a method for treating bacterial infections, preferably infections caused by FimH expressing bacteria, comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non toxic, potent and selective c-kit inhibitor, wherein said inhibitor is unable to promote detah of IL-3 dependent cells cultured to presence of IL-3.

摘要翻译： 本发明涉及一种治疗细菌感染的方法，优选由FimH表达细菌引起的感染，包括向需要这种治疗的人施用酪氨酸激酶抑制剂，更特别是无毒，有效和选择性的c-kit抑制剂，其中 所述抑制剂不能促进培养至存在IL-3的IL-3依赖性细胞的分离。

公开(公告)号：EP3359195A1

公开(公告)日：2018-08-15

申请号：EP16777993.3

申请日：2016-10-05

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K45/06 ,  A61K31/155 ,  A61K31/497 ,  A61K31/506 ,  A61K31/52 ,  A61K31/553 ,  A61P35/00

CPC分类号： A61K31/155 ,  A61K31/497 ,  A61K31/506 ,  A61K31/52 ,  A61K31/553 ,  A61K45/06

摘要： The present invention relates to a method for treating severe systemic mastocytosis, more particularly for treating systemic mastocytosis in patients suffering from severe mast cell mediator release associated handicap, comprising administering a tyrosine kinase inhibitor or a pharmaceutically acceptable salt or solvate thereof, preferably masitinib or a pharmaceutically acceptable salt or solvate thereof, to patients in need thereof.

公开(公告)号：EP2903616B1

公开(公告)日：2017-12-13

申请号：EP13773731.8

申请日：2013-10-04

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre ,  PIQUEMAL, David

IPC分类号： A61K31/496 ,  A61K31/7068 ,  A61P35/00

CPC分类号： A61K31/496 ,  A61K31/7068 ,  A61K45/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  A61K2300/00

公开(公告)号：EP2117531A1

公开(公告)日：2009-11-18

申请号：EP08707865.5

申请日：2008-01-11

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/337 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/7068 ,  A61P35/00

CPC分类号： A61K31/426 ,  A61K31/337 ,  A61K31/421 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/7068 ,  A61K2300/00

摘要： The present invention relates to a method for treating solidcancers including non-small 5 cell lung cancer, pancreatic, bladder, breast and ovarian cancer as well as advanced biliary tract cancers comprising administering at least one antineoplasticagent such as a nucleotide analog, for example gemcitabine, or an antimitotic such as docetaxel, in combination with a tyrosine kinase inhibitor selected from2-aminoarylthiazoles and 2- aminoaryloxazoles.

公开(公告)号：EP1490067B1

公开(公告)日：2008-09-17

申请号：EP03743001.4

申请日：2003-02-26

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/505 ,  A61P25/30

CPC分类号： G01N33/5047 ,  A61K31/404 ,  A61K31/505 ,  A61K31/517 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/502 ,  G01N2333/912 ,  G01N2500/10

摘要： The present invention relates to a method for treating substance use disorders, more particularly drug addiction, drug habituation, drug dependence, withdrawal syndrome and overdose, comprising administering a compound capable of depleting mast cells to a human in need of such treatment. Such compounds can be chosen from tyrosine kinase inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

公开(公告)号：EP1597398B1

公开(公告)日：2008-04-23

申请号：EP04715423.2

申请日：2004-02-27

申请人： AB Science

发明人： KINET, Jean-Pierre ,  MOUSSY, Alain

IPC分类号： C12Q1/68 ,  A61K31/00 ,  C07D417/04

CPC分类号： A61K31/00 ,  C07D417/04 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to a method for a tailored treatm ent of mastocytosis comprising a) assessing whether or not a c-kit mutation at position 816 is detected in a sample of a patient and b) administering a specific 816 mutant c-kit inhibitor in case a mutation is detected in step a) or an inhibitor displaying efficacy on c-kit wild in case no mutation is detected in step a). The invention is more particularly suited 10 for treating category II, III and IV mastocytosis.

公开(公告)号：EP1758654A1

公开(公告)日：2007-03-07

申请号：EP05737503.2

申请日：2005-04-19

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61P33/06 ,  A61K31/45

CPC分类号： A61K31/45 ,  Y02A50/411 ,  Y02A50/421

摘要： The present invention relates to a method for treating plasmodium related diseases comprising administering a compound capable of inhibiting tyrosine kinases, to a human in need of such treatment. Such compounds can be chosen from tyrosine kinase inhibitors including c-kit inhibitors and more particularly non-toxic, selective and potent tyrosine kinases inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

公开(公告)号：EP1742633A2

公开(公告)日：2007-01-17

申请号：EP05738349.9

申请日：2005-04-19

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/497 ,  A61K31/5355 ,  A61K31/4436 ,  A61K31/427 ,  A61K31/4178 ,  A61K31/4433 ,  A61K31/506 ,  A61K31/517 ,  A61P37/00

CPC分类号： A61K31/497 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355

摘要： The present invention relates to a method for treating fibrosis and related disorders comprising administering a compound capable of depleting mast cell or a compound inhibiting mast cells degranulation, to a human in need of such treatment. Such compounds can be chosen from c-kit inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

公开(公告)号：EP1401413B1

公开(公告)日：2006-11-22

申请号：EP02755512.7

申请日：2002-06-28

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61P37/08 ,  A61K31/506

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/015 ,  A61K31/095 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/66 ,  G01N2333/70596 ,  A61K2300/00

摘要： The present invention relates to a method for treating allergic diseases such as asthma, comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

公开(公告)号：EP1478380A2

公开(公告)日：2004-11-24

申请号：EP03712535.8

申请日：2003-02-26

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K38/00

CPC分类号： A61K31/47 ,  A61K31/00 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/66

摘要： The present invention relates to a method for treating CNS disorders, more particularly selected from the group consisting of depression, schizophrenia, anxiety, migraine, memory loss, pain and neurodegenerative diseases, comprising administering a compound capable of depleting mast cells to a human in need of such treatment. Such compounds can be chosen from tyrosine kinase inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.