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    LATERAL FLOW ASSAY WITH TEST STRIP RETAINER
    12.
    发明公开
    LATERAL FLOW ASSAY WITH TEST STRIP RETAINER 有权
    侧流测试麻醉剂测试仪

    公开(公告)号：EP2962104A1

    公开(公告)日：2016-01-06

    申请号：EP14757350.5

    申请日：2014-02-25

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  VAN BOSCH, John

    IPC分类号： G01N33/538 ,  G01N33/52 ,  G01N33/92

    CPC分类号： G01N33/54386 ,  B01L3/5023 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2300/0887 ,  B29C45/44 ,  B29C45/4407 ,  B29C2045/4492 ,  G01N33/525 ,  G01N33/558

    摘要： It is an object of the present invention to provide improved methods and compositions for manufacture and use of lateral flow test devices. In particular, the present invention provides a molding method which provides one or more features in the housing base configured to retain the test strip within the base. These features are provided as undercuts in the housing base. The test strip is configured as a bibulous lateral flow material disposed on a substantially non-compressible base layer, and the base layer is positioned within the undercut in order to retain the test strip in the housing base. Optionally, one or more features in the housing base which create the undercut are configured to engage the bibulous lateral flow material by compression and/or friction, thereby increasing the ability of the base to maintaining the test strip in its proper position within the device.

    摘要翻译： 本发明的目的是提供用于制造和使用侧流试验装置的改进方法和组合物。 特别地，本发明提供了一种模制方法，其提供在壳体基座中的一个或多个特征，其被配置为将测试条保持在基部内。 这些特征作为底座提供在外壳底座中。 测试条被配置为设置在基本上不可压缩的基底层上的吸水性侧向流动材料，并且基底层位于底切中以便将测试条保持在壳体基部中。 可选地，形成底切的壳体底座中的一个或多个特征被构造成通过压缩和/或摩擦接合吸水性侧向流动材料，从而增加基部将测试条保持在其在设备内的正确位置的能力。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    13.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2820146A1

    公开(公告)日：2015-01-07

    申请号：EP13755796.3

    申请日：2013-02-27

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： C12Q1/00 ,  G01N33/50 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  A61M1/1601 ,  A61M2202/0413 ,  A61M2205/75 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of SPARC, Follistatin-related protein 1, Tumor necrosis factor receptor superfamily member 21, Growth arrest-specific protein 1, MHC class I polypeptide-related sequence A, Syndecan-1, and WNTl-inducible-signaling pathway protein 1 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用一种或多种配置成检测选自SPARC，Follistatin相关蛋白1，肿瘤坏死因子受体超家族成员21，生长停滞特异性蛋白1，MHC I类多肽相关序列A，Syndecan-1和WNT1诱导型信号传导通路蛋白1作为肾损伤中的诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    17.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2480882A1

    公开(公告)日：2012-08-01

    申请号：EP10818036.5

    申请日：2010-09-21

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： G01N33/48 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of metalloproteinase inhibitor 2, soluble oxidized low-density lipoprotein receptor 1, interleukin-2, von Willebrand factor, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor receptor superfamily member 11B, neutrophil elastase, interleukin-1 beta, heart-type fatty acid-binding protein, beta-2-glycoprotein 1, soluble CD40 ligand, coagulation factor VII, C—C motif chemokine 2, IgM, CA 19-9, IL-10, TNF-α, and myoglobin as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用多种测定法，其中一种或多种测定法被配置为检测选自由金属蛋白酶抑制剂2，可溶性氧化低密度脂蛋白受体1，白细胞介素-2，von Willebrand因子，粒细胞 - 巨噬细胞集落刺激因子，肿瘤坏死因子受体超家族成员11B，嗜中性粒细胞弹性蛋白酶，白细胞介素-1β，心型脂肪酸结合蛋白，β-2-糖蛋白1，可溶性CD40配体，凝血因子VII ，C-motif趋化因子2，IgM，CA 19-9，IL-10，TNF-α和肌红蛋白作为肾损伤中的诊断和预后生物标志物。