-
公开(公告)号：EP3409362A1
公开(公告)日：2018-12-05
申请号：EP17173730.7
申请日：2017-05-31
发明人： DREIBHOLZ, Jörg , HÜLLEN, Volker , DAMBACH, Maria , FINK, Herbert , PFIFFI, Daniela , HILLER, Bernd , HORN, Carina
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/047 , B01L2300/0663 , B01L2300/0825 , B01L2300/0887 , B01L2300/12 , B01L2300/161 , B01L2400/0406 , B01L2400/088
摘要： A method for manufacturing a test element (110) for detecting at least one analyte in a body fluid (182), a test element (110) for detecting at least one analyte in a body fluid (182), a method for detecting at least one analyte in a body fluid (182), a system for detecting at least one analyte in a body fluid (182) and a method for manufacturing a test element (110) for detecting at least one analyte in a body fluid (182) are disclosed. The method for manufacturing a test element for detecting at least one analyte in a body fluid comprises the following steps:
a) providing at least one substrate (114) having at least one elongate receptacle (122) on a substrate surface (118) of the substrate (114);
b) placing at least one test chemical (138) on the substrate (114) in a manner that the test chemical (138) covers a partition (139) of the elongate receptacle (122);
c) placing at least one cover element (146) on the substrate (114) such that the cover element (146) covers the elongate receptacle (122) at least partially, whereby a channel (148) having a channel surface (154) is formed;
wherein at least one hydrophilic material (136) is applied in a manner that at least one surface section (160) of the channel surface (154) is covered with the hydrophilic material (136), wherein the surface section (160) is adjacent to the test chemical (138).-
2.发明公开
公开(公告)号：EP3401052A1
公开(公告)日：2018-11-14
申请号：EP18178481.0
申请日：2012-11-07
申请人： PICOSYS INCORPORATED
发明人： KARAM, Raymond, Miller , ROUSSOS, Georges , FINKLE, Mark , HARVEY, Daniella, M. , ACKERMAN-KARAM, Pascal, R.
IPC分类号： B23K26/20 , C03B23/20 , B23K103/18
CPC分类号： B29C65/1612 , B01L3/502707 , B01L2200/12 , B01L2300/0887 , B23K26/032 , B23K26/046 , B23K26/0622 , B23K26/082 , B23K26/0853 , B23K26/211 , B23K26/244 , B23K26/32 , B23K26/324 , B23K37/0435 , B23K2101/18 , B23K2101/40 , B23K2103/18 , B23K2103/42 , B23K2103/50 , B23K2103/52 , B23K2103/54 , B29C65/1635 , B29C65/1638 , B29C65/1654 , B29C65/1683 , B29C65/7841 , B29C65/7847 , B29C66/1122 , B29C66/45 , B29C66/73161 , B29C66/7392 , B29C66/7465 , B32B37/06 , B32B2307/412 , B32B2310/0843 , B32B2315/08 , C03B23/203 , C03C27/00
摘要： An apparatus for room temperature laser bonding comprising an x-axis motion stage (32) mounted to a base (33); a y-axis motion stage (34) mounted to the x-axis motion stage; a substrate alignment fixture (36) mounted on the y-axis motion stage, said alignment fixture adapted to align and secure at least two substrates with a mutual interface as a workpiece; a gantry (44) mounted to the base and supporting alignment optics (46) for a laser (14) to focus on the workpiece in the alignment fixture; and a controller (55) for translation of the x-axis motion stage and y-axis motion stage for motion of the focused laser on the workpiece.
-
公开(公告)号：EP2686154B1
公开(公告)日：2018-11-14
申请号：EP12757703.9
申请日：2012-03-12
发明人： MALIC, Lidija , MORTON, Keith , VERES, Teodor
IPC分类号： B01L3/00 , G01N21/552 , G01N21/65 , B82Y30/00
CPC分类号： G01N21/65 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/044 , B01L2300/0654 , B01L2300/0822 , B01L2300/0861 , B01L2300/0887 , B01L2300/0896 , B01L2300/12 , B01L2400/086 , B82Y30/00 , C12M23/16 , G01N21/554 , G01N21/658 , Y10T137/8593
摘要： A microfluidic system has a monolithic biocompatible substrate with both a surface having an ordered array of nano-scale elements for plasmonic response monitoring and a network of microchannels. Advantageously, low-volume consumption, rapid low-cost fabrication of molds with easily interchangeable microfluidic channel layouts, mass production, and in situ label-free real-time detection of cellular response, viability, behavior and biomolecular binding using plasmonic techniques can be provided. A ratio of greater than 0.2 of the cross-sectional dimension and the spacing between the nano-scale elements is useful for plasmonic response monitoring. Producing such a system involves a master mold with the nano-scale elements etched into a hard substrate, and the network provided in a soft membrane bonded to the hard substrate. A stamp may be created by setting a settable liquid polymer or metal placed in the master mold. Features of the intended device can be transferred to a polymeric substrate using the stamp.
-
公开(公告)号：EP3369483A1
公开(公告)日：2018-09-05
申请号：EP17159079.7
申请日：2017-03-03
发明人： HAUPT, Michael , LOSKILL, Peter
CPC分类号： B81C1/00206 , B01L3/502707 , B01L2200/0689 , B01L2300/069 , B01L2300/0816 , B01L2300/0887 , B32B7/02 , B32B27/283 , B81B2201/058
摘要： A polymeric device, in particular microfluidic device (100), cell culture system or membrane comprising a system (20) of microchannels (25), wells and/or pores, in a polymeric device (10), wherein at least a part of the surface area of the microchannels (25) is formed by an absorption barrier layer system, wherein the absorption barrier layer system comprises at least one polymeric interface layer (40) and at least one barrier coating layer (50).
-
公开(公告)号：EP3366370A1
公开(公告)日：2018-08-29
申请号：EP17157421.3
申请日：2017-02-22
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00398 , B01J2219/00418 , B01J2219/00477 , B01J2219/00689 , B01J2219/00722 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , B01L2400/0638 , F16K99/0015 , F16K2099/0084
摘要： Um eine kostengünstige und zeitnahe Synthese auch von geringen Mengen an Oligonukleotiden zu ermöglichen wird erfindungsgemäß eine die folgenden Bestandteile umfassende Vorrichtung vorgeschlagen:
- eine Reagenzbehälter-Aufnahme (1) zur Aufnahme eines mehrere Reagenzbehälter (18) umfassenden Reagenzbehälter-Trägers (17);
- einen wechselbaren mikrofluidischen Chip (10) umfassend eine Synthesekammer, fluidische Anschlüsse sowie mikrofluidische Ventile;
- eine Steuereinrichtung (5);
- fluidische Verbindungsmittel (2);
wobei die Vorrichtung in einer Bestückungsposition mit dem mikrofluidischen Chip (10) und mit dem Reagenzbehälter-Träger (17) bestückbar ist,
wobei die Reagenzbehälter-Aufnahme (1), der mikrofluidische Chip (10) und die fluidischen Verbindungsmittel (2) von der Bestückungsposition in eine Betriebsposition bringbar sind,
in welcher Betriebsposition die Reagenzbehälter-Aufnahme (1), der mikrofluidische Chip (10) und die fluidischen Verbindungsmittel (2) derart zueinander positioniert sind,
dass die mikrofluidischen Ventile des mikrofluidischen Chips (10) an der Steuereinrichtung (5) angeschlossen sind,
dass in der Reagenzbehälter-Aufnahme (1) angeordnete Reagenzbehälter (18) über die fluidischen Verbindungsmittel (2) mit den fluidischen Anschlüssen verbunden sind,
sodass in Abhängigkeit der Ventilstellung der mikrofluidischen Ventile Reagenzien aus den Reagenzbehältern (18) in Richtung der Synthesekammer (14) förderbar sind.-
公开(公告)号：EP2528687B1
公开(公告)日：2018-08-22
申请号：EP11705075.7
申请日：2011-01-28
申请人： Micronics, Inc.
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/52 , B01L7/52 , B01L7/525 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/03 , G01N21/0332 , G01N21/17 , G01N21/64 , G01N21/6428 , Y10T137/0318
摘要： A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.
-
公开(公告)号：EP3245002A4
公开(公告)日：2018-08-01
申请号：EP16748789
申请日：2016-01-13
发明人： BRANSKY AVISHAY , SHLOMO LIRON , ROTEM NIR
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2300/046 , B01L2300/0816 , B01L2300/0838 , B01L2300/087 , B01L2300/0877 , B01L2300/0887 , B01L2300/12 , B01L2300/123 , B01L2400/049 , B01L2400/0683
摘要： A disposable cartridge may have a fluid analysis chip for receiving a fluid to be analyzed. The fluid analysis chip may be attached to a fluid preparation unit of the disposable cartridge and may include a base layer. The fluid analysis chip may also include a spacer layer disposed over the base layer, the spacer layer including a microchannel formed therein, the microchannel being configured to guide a flow of the fluid to be analyzed within the fluid analysis chip. The fluid analysis chip may also include a cap layer disposed over the spacer layer, the cap layer including an inlet and an outlet for establishing fluid communication with the microchannel included in the spacer layer, and an interface layer disposed over the cap layer, the interface layer being configured to attach the fluid analysis chip to the fluid preparation unit of the disposable cartridge.
-
公开(公告)号：EP2292710B1
公开(公告)日：2018-08-01
申请号：EP10183927.2
申请日：2004-10-13
申请人： Rheonix, Inc.
发明人： Zhou, Peng , Young, Lincoln C.
CPC分类号： B29C66/54 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B29C65/4815 , B29C65/483 , B29C65/4895 , B29C66/543 , B29C66/71 , B29L2031/756 , B29K2069/00 , B29K2033/08 , B29K2025/06
摘要： A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.
-
公开(公告)号：EP2711415A3
公开(公告)日：2018-07-18
申请号：EP13198399.1
申请日：2003-12-23
发明人： Glazer, Eli N. , Leland, Jonathan K. , Billadeau, Mark A. , Leginus, Joseph M. , Jeffrey-Coker, Bandele , Debad, Jeff D. , Phalnikar, Koustubh A. , Jambunathan, Sriram
IPC分类号： C12Q1/00 , G01N33/543 , B01L3/00
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： An assay cartridge comprises: an extraction reagent chamber for holding an extraction reagent; a sample chamber adapted to receive an applicator stick, said sample chamber connected to said extraction reagent chamber by an extraction reagent conduit, said sample chamber having a sample introduction port with a sealable closure; and a first detection chamber connected to said sample chamber by a first sample conduit.
-
公开(公告)号：EP3338078A1
公开(公告)日：2018-06-27
申请号：EP16756771.8
申请日：2016-08-19
发明人： HAND, Chris , HOFMANN, Oliver , RYU, Gihan , RAMON, Miguel , KAY, Christopher John , BENZIE, Philip William
CPC分类号： G01N21/8483 , B01L3/5023 , B01L2300/0636 , B01L2300/0654 , B01L2300/0825 , B01L2300/0887 , G01N21/6454 , G01N33/558 , G01N2201/0221
摘要： An assay device for quantitatively determining analyte concentration in a liquid sample comprises a light-transmissive lateral flow membrane 46 having multiple test regions 41, 41A; planar organic light emitting diodes (OLEDs) 44, 44B; planar organic photodetectors (OPDs) 49, 49B; wherein each test region is aligned with the emission layer of one emitter and the absorption layer of one photodetector, the aligned emitter, photodetector, and test region forming a group; wherein for each group, when the test region is wet and devoid of tagging particles, e.g. fluorescent tagging particles, cross-talk C = 20 log10 (I1/(I2-I1)) is greater than 20 dB for at least one group, with I1 the energised photodetector photocurrent with the group emitter energised, and I2 that with the group emitter and one other emitter energised. The emitter and detector may be formed on a common substrate which is folded about the lateral flow membrane.
-
-
-
-
-
-
-
-
-
搜索结果
1935 条记录 (耗时 0.026 秒)
