公开(公告)号：EP2791143A1

公开(公告)日：2014-10-22

申请号：EP12809680.7

申请日：2012-12-11

申请人： Bayer Intellectual Property GmbH ,  Bayer Pharma Aktiengesellschaft

发明人： COLLIN, Marie-Pierre ,  BROHM, Dirk ,  HÉROULT, Mélanie ,  LOBELL, Mario ,  HÜBSCH, Walter ,  LUSTIG, Klemens ,  GRÜNEWALD, Sylvia ,  BÖMER, Ulf ,  VÖHRINGER, Verena ,  LINDNER, Niels

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K31/553 ,  C07D409/04 ,  C07D409/14

摘要： This invention relates to novel substituted 5-(l-benzothiophen-2-yl)pyrrolo[2,l-fJ[l,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.

公开(公告)号：EP2751106A1

公开(公告)日：2014-07-09

申请号：EP12766292.2

申请日：2012-08-30

申请人： Bayer Intellectual Property GmbH ,  Bayer Pharma Aktiengesellschaft

发明人： FOLLMANN, Markus ,  STASCH, Johannes-Peter ,  REDLICH, Gorden ,  GRIEBENOW, Nils ,  LANG, Dieter ,  WUNDER, Frank ,  HÜBSCH, Walter ,  LINDNER, Niels ,  VAKALOPOULOS, Alexandros ,  TERSTEEGEN, Adrian

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61P9/00

CPC分类号： A61K31/519 ,  A61K31/527 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/20 ,  C07D498/08 ,  C07D519/00

摘要： The present application relates to new substituted annellated pyrimidines, a method for the production thereof, the use thereof in isolation or in combination for the treatment and/or prophylaxis of diseases, and the use thereof to produce medicines for the treatment and/or prophylaxis of diseases, more particularly for the treatment and/or prophylaxis of cardiovascular diseases.

摘要翻译： 本申请涉及新型取代的环状嘧啶，其生产方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防心血管疾病。