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1.发明公开SUBSTITUIERTE, ANNELLIERTE IMIDAZOLE UND PYRAZOLE UND IHRE VERWENDUNG 有权SUBSTITUIERTE，ANNELLIERTE IMIDAZOLE UND PYRAZOLE UND IHRE VERWENDUNG
公开(公告)号：EP2802587A2
公开(公告)日：2014-11-19
申请号：EP13700985.8
申请日：2013-01-08
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , PAULSEN, Holger , HÜBSCH, Walter , TERSTEEGEN, Adrian , VAKALOPOULOS, Alexandros
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61K31/53 , A61P9/10 , A61P9/12
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The invention relates to novel substituted, annulated imidazoles and pyrazoles, methods for the production thereof, the use thereof alone or in combination for the treatment and/or prophylaxis of diseases, and the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新型取代的稠合咪唑和吡唑，其制备方法，单独或组合用于治疗和/或预防疾病及其用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：EP2751106B1
公开(公告)日：2017-10-18
申请号：EP12766292.2
申请日：2012-08-30
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , HÜBSCH, Walter , LINDNER, Niels , VAKALOPOULOS, Alexandros , TERSTEEGEN, Adrian
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61P9/00
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/08 , C07D519/00
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3.发明授权SUBSTITUIERTE, ANNELLIERTE IMIDAZOLE UND PYRAZOLE UND IHRE VERWENDUNG 有权SUBSTITUIERTE，ANNELLIERTE IMIDAZOLE UND PRARAZOLE和IHRE VERWENDUNG
公开(公告)号：EP2802587B1
公开(公告)日：2017-09-06
申请号：EP13700985.8
申请日：2013-01-08
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , PAULSEN, Holger , HÜBSCH, Walter , TERSTEEGEN, Adrian , VAKALOPOULOS, Alexandros
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61K31/53 , A61P9/10 , A61P9/12
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
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公开(公告)号：EP2802592A1
公开(公告)日：2014-11-19
申请号：EP13700288.7
申请日：2013-01-10
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , HÜBSCH, Walter , TERSTEEGEN, Adrian , VAKALOPOULOS, Alexandros
IPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61P9/10 , A61P9/12
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The application relates to novel substituted annulated pyrimidines and triazines, methods for the production thereof, the use thereof alone or in combination for the treatment and/or prophylaxis of diseases, and the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
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公开(公告)号：EP2705038A1
公开(公告)日：2014-03-12
申请号：EP12724584.3
申请日：2012-05-02
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , STRAUB, Alexander , ACKERSTAFF, Jens , GRIEBENOW, Nils , KNORR, Andreas , WUNDER, Frank , LI, Volkhart, Min-Jian
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/53 , A61K45/06
摘要： The invention relates to novel substituted imidazopyridazines, to a method for the production thereof, to the individual or combined use thereof for the treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及具有下式（I）的新型取代的咪唑并哒嗪：其制备方法，其用途，单独或组合用于治疗和/或预防疾病及其用于生产药物的用途 治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：EP2705037A1
公开(公告)日：2014-03-12
申请号：EP12717331.8
申请日：2012-05-02
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , LI, Volkhart Min-Jian
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5365
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06 , C07D487/04
摘要： The invention relates to novel substituted imidazopyridines and imidazopyridazines, to a method for the production thereof, to the individual or combined use thereof for the treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.
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公开(公告)号：EP3075395B1
公开(公告)日：2017-11-22
申请号：EP15192265.5
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
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8.发明授权POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF 有权西班牙语VERWENDUNG的ADRENOMEDULLIN-PRODRUG AUF POLYETHYLINGLYKOLBASIS
公开(公告)号：EP2773376B1
公开(公告)日：2016-01-13
申请号：EP12783566.8
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
摘要翻译： 本发明涉及包含新型聚乙二醇（PEG）基于前体药物的肾上腺髓质素或其盐之一，其溶剂化物或其盐的溶剂合物与惰性无毒药学上合适的赋形剂组合的药物，其中药物为药物形式 用于吸入，其用于治疗和/或预防特定PEG-肾上腺髓质素前体药物及其合成中间体的疾病，特别是心血管，水肿和/或炎症性疾病的疾病。
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公开(公告)号：EP2773376A1
公开(公告)日：2014-09-10
申请号：EP12783566.8
申请日：2012-10-30
发明人： FLAMME, Ingo , KÖBBERLING, Johannes , LERCHEN, Hans-Georg , GRIEBENOW, Nils , SCHOHE-LOOP, Rudolf , WITTROCK, Sven , KÖLLNBERGER, Maria , WUNDER, Frank , REDLICH, Gorden , KNORR, Andreas , MARLEY, July , PRITCHARD, Iain
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates medicaments comprising novel polyethylene glycol (PEG) based prodrugs of Adrenomedullin, or one of the salts thereof, solvates thereof or the solvates of salts thereof, in combination with an inert nontoxic pharmaceutically suitable excipient, wherein the medicament is in a pharmaceutical form for inhalation, its use for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, to specific PEG-adrenomedullin prodrugs and its synthesis intermediates.
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10.发明授权
公开(公告)号：EP2705037B1
公开(公告)日：2016-06-22
申请号：EP12717331.8
申请日：2012-05-02
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , LI, Volkhart Min-Jian
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5365
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06 , C07D487/04
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