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公开(公告)号：EP1806143A2
公开(公告)日：2007-07-11
申请号：EP07100908.8
申请日：2000-08-16
发明人： Mackay, Fabienne , Browning, Jeffrey , Ambrose, Christine , Tschopp, Jurg , Schneider, Pascal , Thompson, Jeffrey
IPC分类号： A61K38/17 , A61K39/395 , A61P37/00 , A61P9/12 , A61P13/12
CPC分类号： C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要： A receptor in the TNF family is provided: BAFF-R, Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译： 提供TNF家族中的受体：还提供了BAFF-R，嵌合分子和对BAFF-R的抗体及其使用方法。
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12.发明公开Soluble lymphotoxin-beta receptors, anti-lymphotoxin receptor antibodies and anti-lymphotoxin ligand antibodies as therapeutic agents for the treatment of immunological diseases 失效可溶性淋巴毒素β受体，淋巴毒素对抗体和抗体Lymphotoxinligand作为治疗剂用于治疗疾病immunogischer
公开(公告)号：EP1723967A2
公开(公告)日：2006-11-22
申请号：EP06013251.1
申请日：1997-10-24
申请人： Biogen Idec MA, Inc.
IPC分类号： A61K39/395 , A61K38/17 , A61K38/55
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7151 , C07K16/241 , C07K16/2878 , C07K2319/00
摘要： Compositions and methods comprising "lymphotoxin-β receptor blocking agents" which block lymphotoxin-β receptor signalling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.
摘要翻译： 组合物和方法，其包含阻止淋巴毒素²受体信号传导和是有用的，用于改变免疫疾病，特别是抗体介导的免疫应答“淋巴毒素受体²阻断剂”。
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公开(公告)号：EP2314694A3
公开(公告)日：2013-12-11
申请号：EP10181130.5
申请日：2000-08-16
发明人： Mackay, Fabienne , Browning, Jeffrey , Ambrose, Christine , Tschopp, Jurg , Schneider, Pascal , Thompson, Jeffrey
IPC分类号： C12N15/12 , C07K14/715 , A61K38/17 , A61K39/395
CPC分类号： C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要： A receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
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14.发明公开A method for the high level expression of active lymphotoxin-beta receptor immunoglobulin chimeric proteins and their purification 有权一种TNF受体家族的一个成员的一个融合蛋白的活性形式的高表达和Ig和它们的纯化方法
公开(公告)号：EP2374872A2
公开(公告)日：2011-10-12
申请号：EP10011212.7
申请日：1999-12-16
申请人： Biogen Idec MA Inc.
CPC分类号： C12P21/00 , A61K38/00 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C12P21/02
摘要： Methods for high level expression of active lymphotoxin-β receptor immunoglogulin chimeric proteins and their purification.
摘要翻译： 方法活性淋巴毒素受体²immunoglogulin嵌合蛋白及其纯化的高水平表达。
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15.发明公开BAFF, inhibitors thereof and their use in the modulation of the B-cell response 有权BAFF，所述抑制剂和它们在调节B细胞响应使用
公开(公告)号：EP2298332A1
公开(公告)日：2011-03-23
申请号：EP10180420.1
申请日：2000-01-25
申请人： Biogen Idec MA Inc. , Apoxis SA
IPC分类号： A61K38/17 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K16/2875 , C07K16/2878
摘要： The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
摘要翻译： 本发明提供用于治疗或预防与BAFF包括BAFF及其片段，抗体，激动剂和拮抗剂的表达相关的病症的方法。
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16.发明公开Soluble lymphotoxin-beta receptors, anti-lymphotoxin receptor antibodies and anti-lymphotoxin ligand antibodies as therapeutic agents for the treatment of immunological diseases 失效可溶性淋巴毒素β受体，淋巴毒素对抗体和抗体Lymphotoxinligand作为治疗剂用于治疗疾病immunogischer
公开(公告)号：EP1723967A3
公开(公告)日：2007-01-10
申请号：EP06013251.1
申请日：1997-10-24
申请人： Biogen Idec MA, Inc.
IPC分类号： A61K39/395 , A61K38/17 , A61K38/55 , C07K19/00
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7151 , C07K16/241 , C07K16/2878 , C07K2319/00
摘要： Compositions and methods comprising "lymphotoxin-β receptor blocking agents" which block lymphotoxin-β receptor signalling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.
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