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1.Treatment of demyelinating disorders with soluble lymphotoxin-beta-receptor 审中-公开
标题翻译: 用可溶性淋巴毒素β受体脱髓鞘疾病的治疗公开(公告)号:EP2311481A3
公开(公告)日:2013-10-16
申请号:EP10157664.3
申请日:2007-10-18
申请人: Biogen Idec MA Inc.
发明人: Browning, Jeffrey
IPC分类号: A61K38/17 , A61K39/395 , A61P25/00 , C07K14/705
CPC分类号: A61K38/1793 , C07K14/70578 , C07K2319/30
摘要: Methods of treating a demyelinating disorder using inhibitors of the lymphotoxin pathway.
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2.
公开(公告)号:EP1415659B9
公开(公告)日:2012-02-15
申请号:EP03018879.1
申请日:2000-01-25
IPC分类号: A61K38/17 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K16/2875 , C07K16/2878
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公开(公告)号:EP1806143A3
公开(公告)日:2007-07-18
申请号:EP07100908.8
申请日:2000-08-16
发明人: Mackay, Fabienne , Browning, Jeffrey , Ambrose, Christine , Tschopp, Jurg , Schneider, Pascal , Thompson, Jeffrey
IPC分类号: A61K38/17 , A61K39/395 , A61P37/00 , A61P9/12 , A61P13/12
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A receptor in the TNF family is provided: BAFF-R, Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供了TNF家族中的受体:还提供了BAFF-R,嵌合分子和抗BAFF-R的抗体及其使用方法。
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4.BAFF, inhibitors thereof and their use in the modulation of the B-cell response 审中-公开
标题翻译: BAFF,及其抑制剂及其用于调制B细胞反应公开(公告)号:EP2319527A3
公开(公告)日:2011-10-12
申请号:EP10181337.6
申请日:2000-01-25
申请人: Biogen Idec MA Inc. , Apoxis SA
IPC分类号: A61K38/17 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K16/2875 , C07K16/2878
摘要: The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
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公开(公告)号:EP2314694A2
公开(公告)日:2011-04-27
申请号:EP10181130.5
申请日:2000-08-16
发明人: Mackay, Fabienne , Browning, Jeffrey , Ambrose, Christine , Tschopp, Jurg , Schneider, Pascal , Thompson, Jeffrey
IPC分类号: C12N15/12 , C07K14/715 , A61K38/17 , A61K39/395
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的受体:BAFF-R。 还提供了嵌合分子和对BAFF-R的抗体及其使用方法。
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6.TWEAK receptor agonists as anti-angiogenic agents 审中-公开
标题翻译: TWEAK Rezeptoragoniste als antiangiogene Agenzien公开(公告)号:EP2260867A1
公开(公告)日:2010-12-15
申请号:EP10181061.2
申请日:2001-09-12
申请人: Biogen Idec MA Inc.
IPC分类号: A61K39/395 , A61K38/17 , A61P35/00 , C07K16/28
CPC分类号: C07K16/2878 , A61K38/00 , A61K2039/505 , C07K2317/73
摘要: The present invention relates to methods of modulating angiogenesis and inhibiting tumor progression by using TWEAK receptor (Fn14) agonists. In particular, methods for inhibiting angiogenesis are disclosed.
摘要翻译: 本发明涉及通过使用TWEAK受体(Fn14)激动剂调节血管发生和抑制肿瘤进展的方法。 特别地,公开了抑制血管发生的方法。
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7.A method for the high level expression of active lymphotoxin-beta receptor immunoglobulin chimeric proteins and their purification 有权
标题翻译: 一种用于淋巴毒素β受体 - 免疫球蛋白融合蛋白和它们的纯化的活性形式的高表达方法公开(公告)号:EP2374872A3
公开(公告)日:2011-10-19
申请号:EP10011212.7
申请日:1999-12-16
申请人: Biogen Idec MA Inc.
IPC分类号: C12N5/10 , C12N1/19 , C12N1/21 , C07K19/00 , A61K38/00 , C07K14/705 , C07K14/715 , C12P21/02
CPC分类号: C12P21/00 , A61K38/00 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C12P21/02
摘要: Methods for high level expression of active lymphotoxin-β receptor immunoglogulin chimeric proteins and their purification.
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8.
公开(公告)号:EP1415659B1
公开(公告)日:2011-07-06
申请号:EP03018879.1
申请日:2000-01-25
申请人: Biogen Idec MA Inc. , Apoxis SA
IPC分类号: A61K38/17 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K16/2875 , C07K16/2878
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9.BAFF, inhibitors thereof and their use in the modulation of the B-cell response 审中-公开
标题翻译: BAFF,及其抑制剂及其用于调制B细胞反应公开(公告)号:EP2319527A2
公开(公告)日:2011-05-11
申请号:EP10181337.6
申请日:2000-01-25
申请人: Biogen Idec MA Inc. , Apoxis SA
IPC分类号: A61K38/17 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K16/2875 , C07K16/2878
摘要: The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
摘要翻译: 本发明提供用于治疗或预防与BAFF包括BAFF及其片段,抗体,激动剂和拮抗剂的表达相关的病症的方法。
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10.Treatment of demyelinating disorders with soluble lymphotoxin-beta-receptor 审中-公开
标题翻译: 百灵ON ON ON TOR EN EN EN EN EN TOR TOR TOR TOR TOR TOR TOR TOR TOR公开(公告)号:EP2311481A2
公开(公告)日:2011-04-20
申请号:EP10157664.3
申请日:2007-10-18
发明人: Browning, Jeffrey
IPC分类号: A61K38/17 , A61M3/00 , A61K39/395 , A61P25/00
CPC分类号: A61K38/1793 , C07K14/70578 , C07K2319/30
摘要: Methods of treating a demyelinating disorder using inhibitors of the lymphotoxin pathway.
摘要翻译: 使用淋巴毒素途径抑制剂治疗脱髓鞘疾病的方法。
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