-
11.
公开(公告)号:EP0984283A2
公开(公告)日:2000-03-08
申请号:EP99203972.7
申请日:1992-02-21
发明人: Carey, Glen A. , Mann, Raymond A. , Lewis, Scott C. , Whitesel, Mary Beth , Polaniec, James P. , Woyansky, George J. , Pabst, Stefan R. , Klingshirn, Frank C.
CPC分类号: B01L3/508 , B01L2300/0854 , G01N21/76 , G01N35/0098 , G01N35/021 , G01N35/025 , G01N35/1002 , G01N35/1065 , G01N2035/00386 , G01N2035/00396 , G01N2035/00524 , G01N2035/00752 , G01N2035/0441 , G01N2035/0443 , G01N2035/0465 , G01N2035/0484 , G01N2035/0486 , G01N2035/1025 , Y10S215/01 , Y10S215/03 , Y10S215/08 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要: Inter alia , an isolation means for an automated analyzer to assay a test sample in a cuvette which is conveyed along an event path, the said cuvette having a bottom wall, a side wall and an open top, the said cuvette containing a labeled reagent and a solid-phase reagent which has paramagnetic particles which have reacted to form a detectable product, characterised in that it comprises:
(a) magnetic means along the said event path for attracting the said paramagnetic particles against the side wall of the said cuvette;
(b) liquid evacuating means for aspirating the liquid from the said cuvette while the said paramagnetic particles are held against the side wall of the said cuvette;
(c) liquid dispensing means which are located downstream of the said magnetic means for dispensing a re-suspend liquid into the said cuvette for re-suspending the said paramagnetic particles in the said re-suspend liquid;
and
(d) control means including a central processing unit for coordinating the said evacuating means, the said liquid dispensing means and means for conveying the said cuvette along the said event path is disclosed.-
公开(公告)号:EP0984270A2
公开(公告)日:2000-03-08
申请号:EP99203973.5
申请日:1992-02-21
发明人: Carey, Glen A. , Mann, Raymond A. , Lewis, Scott C. , Whitesel, Mary Beth , Polaniec, James P. , Woyansky, George J. , Pabst, Stefan R. , Klingshirn, Frank C.
CPC分类号: B01L3/508 , B01L2300/0854 , G01N21/76 , G01N35/0098 , G01N35/021 , G01N35/025 , G01N35/1002 , G01N35/1065 , G01N2035/00386 , G01N2035/00396 , G01N2035/00524 , G01N2035/00752 , G01N2035/0441 , G01N2035/0443 , G01N2035/0465 , G01N2035/0484 , G01N2035/0486 , G01N2035/1025 , Y10S215/01 , Y10S215/03 , Y10S215/08 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要: Inter alia , a luminometer for an automated analyzer to assay an analyte in a test sample in a cuvette in which the product of the test reaction includes a chemiluminescent labeled reagent and the product being suspended in an acid solution, the said cuvette having a bottom wall, side wall and an open top, characterised in that it comprises:
(a) a cuvette transport for conveying the said cuvette in a horizontal plane from an entrance point to a base solution dispense point and to an exit point;
(b) dispense means at the said base solution dispense point for dispensing a base solution into the said cuvette to cause a chemiluminescent flash;
(c) an instrument at the said base solution dispense point for measuring the intensity of the said flash;
and
(d) control means including a central processing unit for coordinating the said cuvette transport, the said dispense means and the said instrument is disclosed.-
公开(公告)号:EP0753735A3
公开(公告)日:1997-05-07
申请号:EP96305122.2
申请日:1996-07-11
CPC分类号: G01N21/76 , G01N21/13 , G01N2035/0448 , Y10T436/114165
摘要: A luminometer for determining the composition of a specimen sample includes an annular guide path for sample containing cuvettes within a light tight housing. A rotor moves spaced segments through the guide path with the cuvettes positioned between the segments. The luminometer further includes one or two detector assemblies (110,112) coupled to the housing and positioned to view and detect light emitted by cuvettes as they pass along the guide path between segments. A cuvette is advanced around the housing via the rotor and rotor segments and when the cuvette reaches a predetermined position on the housing, a reagent, such as a base, is added to the cuvette to initiate a chemiluminescent reaction within the cuvette and provide an emission of light energy in a predetermined spectral range. The luminometer has a waste aspiration probe to remove the contents of the cuvette after it passes the detector. A cuvette elevator moves a sample containing cuvette into the guide path between segments and an exit chute removes cuvettes after their contents have been aspirated. The luminometer permits continuous uninterrupted sample testing when coupled to an incubation chamber in which the cuvettes receive samples and test specific reagents before they are moved into the luminometer by the elevator. The luminometer has a temperature detection and control circuit coupled to the detector (PMT) (110) with thermal insulating sleeve (126). A TED (132) is coupled to the PMT thermal sleeve. The PMT comprises a lens cap (128) and a seal.
-
公开(公告)号:EP0712000A3
公开(公告)日:1996-06-26
申请号:EP95306882.2
申请日:1995-09-29
发明人: Carey, Glen A. , Malek, Michael L.
IPC分类号: G01N35/02 , G01N33/543
CPC分类号: B01L3/50853 , G01N35/0092 , G01N35/0098 , G01N35/025 , G01N2035/0455 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要: Method and apparatus for transportation and processing of multiple protocol assays within an automated immunoassay analyzer instrument (10). The apparatus includes a cuvette ring (32) movably coupled to a magnet ring (30). In one embodiment, the magnet ring (30) and cuvette ring (32) are provided having circular shapes. A temperature controlled housing (28) is disposed about the cuvette and magnet rings to provide a rotary incubation and particle separation chamber (12). The cuvette ring (32) holds a plurality of cuvettes each of which may have a different assay disposed therein. The cuvette ring (32) advances the cuvettes around the circumference of the incubation chamber. A plurality of discrete processing centers for aspiration and dispensing fluid samples, reagents and wash fluids are disposed at predetermined positions about the incubation chamber (12). The cuvette ring (32) moves cuvettes in both clockwise and counter clockwise directions around the incubation chamber (12) to position particular cuvettes at particular ones of the plurality of discrete processing centers to thus accomodate different protocols of each of the assays. By controlling the manner in which the cuvette ring (32) moves within the incubation chamber (12), a plurality of different protocol assays each of which require different incubation times, can be simultaneously processed in the analyzer instrument.
摘要翻译: 用于在自动化免疫分析分析仪器(10)内运输和处理多方案分析的方法和装置。 该设备包括可移动地联接到磁环(30)的比色皿环(32)。 在一个实施例中,磁环(30)和比色皿环(32)被提供为具有圆形形状。 温控外壳(28)围绕比色皿和磁环设置,以提供旋转培养和颗粒分离室(12)。 比色杯环(32)容纳多个比色杯,每个比色杯可以具有设置在其中的不同化验。 比色杯环(32)围绕孵育室的圆周推进比色杯。 用于抽吸和分配流体样品,试剂和洗涤流体的多个离散处理中心设置在围绕孵育室(12)的预定位置处。 比色皿环(32)围绕孵育室(12)沿顺时针和逆时针方向移动比色杯以将特定比色杯定位在多个离散处理中心中的特定比色杯中,从而适应每种测定的不同方案。 通过控制比色皿环(32)在孵育室(12)内移动的方式,可以在分析仪器中同时处理多个不同的方案测定,其中每一个需要不同的温育时间。
-
公开(公告)号:EP0502638A3
公开(公告)日:1994-05-11
申请号:EP92301483.1
申请日:1992-02-21
发明人: Carey, Glen A. , Lewis, Scott C. , Mann, Raymond A. , Whitesel, Mary Beth , Polaniec, James P. , Woyansky, George J. , Pabst, Stefan R. , Klingshirn, Frank C.
CPC分类号: B01L3/508 , B01L2300/0854 , G01N21/76 , G01N35/0098 , G01N35/021 , G01N35/025 , G01N35/1002 , G01N35/1065 , G01N2035/00386 , G01N2035/00396 , G01N2035/00524 , G01N2035/00752 , G01N2035/0441 , G01N2035/0443 , G01N2035/0465 , G01N2035/0484 , G01N2035/0486 , G01N2035/1025 , Y10S215/01 , Y10S215/03 , Y10S215/08 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要: An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent aspirating and dispensing probes, a separation system for separating bound from unbound tracer or labeled reagent, a detection system and date collection/processing system. All of the sub-units of the machine are controlled by a central processing unit to coordinate the activity of all of the subunits of the analyzer. The analyzer is specifically suited for performing heterogeneous binding assay protocols, particularly immunoassays.
-
-
-
-