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公开(公告)号：EP2455399A2
公开(公告)日：2012-05-23
申请号：EP12153016.6
申请日：2007-09-06
申请人： Crucell Holland B.V.
IPC分类号： C07K16/10 , A61K39/145 , C12N5/10 , C12N15/09
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12N2760/16122
摘要： The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross-subtype protection in vivo , such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
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12.发明公开Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof 审中-公开能够中和流感病毒H5N1的人结合分子及其用途
公开(公告)号：EP2450377A1
公开(公告)日：2012-05-09
申请号：EP12153010.9
申请日：2007-09-06
申请人： Crucell Holland B.V.
IPC分类号： C07K16/10 , A61K39/145 , C12N5/10 , C12N15/09
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross-subtype protection in vivo , such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
摘要翻译： 本发明涉及结合分子，例如结合流感病毒H5N1并具有针对流感病毒H5N1的中和活性的人单克隆抗体。 本公开提供了编码抗体的核酸分子，它们的序列和包含抗体的组合物以及鉴定或产生抗体的方法。 该抗体可用于流感病毒H5N1感染的诊断，预防和/或治疗。 在一个优选的实施方案中，抗体在体内提供交叉亚型保护，从而可以预防和/或治疗基于H5，H2，H6，H9和H1的流感亚型的感染。
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13.发明公开Human binding molecules having killing activity against staphylococci and uses thereof 有权人结合分子具有杀伤活性对葡萄球菌及其使用
公开(公告)号：EP2395018A1
公开(公告)日：2011-12-14
申请号：EP11170742.8
申请日：2007-06-05
申请人： Crucell Holland B.V.
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77
摘要： The present invention provides human binding molecules specifically binding to staphylococci and having killing activity against staphylococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Staphylococcus.
摘要翻译： 本发明提供了人结合分子特异性结合葡萄球菌和具有杀伤活性对抗葡萄球菌，编码人结合分子，组合物，包含所述人结合分子和识别或产生所述人结合分子的方法的核酸分子。 人结合分子可以在来自金黄色引起的病症的诊断，预防和/或治疗中使用。
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14.发明公开
公开(公告)号：EP2314621A1
公开(公告)日：2011-04-27
申请号：EP10180398.9
申请日：2005-05-26
申请人： Crucell Holland B.V.
发明人： Bakker, Alexander, Berthold, Hendrik , Marissen, Willem Egbert , De Kruif, Cornelis Adriaan , Kramer, Robert Arjen
CPC分类号： C07K16/10 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N2760/20122 , G01N33/56983
摘要： The present invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. Preferably, they can be used in the postexposure prophylaxis of rabies.
摘要翻译： 本发明提供了结合分子也特异性结合于狂犬病病毒和能够中和所述病毒。 本发明提供编码所述结合分子的另外的核酸分子，组合物，包含所述结合分子和识别或产生结合分子的方法。 结合分子可以在从狂犬病病毒引起的疾病的诊断，预防和/或治疗中使用。 优选的是，他们可以在狂犬病暴露后预防中使用。
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15.发明授权Human binding molecules having killing activity against staphylococci and uses thereof 有权人结合分子具有杀伤活性对葡萄球菌及其使用
公开(公告)号：EP2395018B1
公开(公告)日：2016-01-27
申请号：EP11170742.8
申请日：2007-06-05
申请人： Crucell Holland B.V.
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77
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16.发明授权Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof 有权为了能中和人结合分子及其用途的H5N1流感病毒
公开(公告)号：EP2455398B1
公开(公告)日：2015-11-18
申请号：EP12153015.8
申请日：2007-09-06
申请人： Crucell Holland B.V.
IPC分类号： A61K39/00 , C07K16/10 , A61K39/145 , C12N5/10 , C12N15/09
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12N2760/16122
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17.发明授权
公开(公告)号：EP2314621B1
公开(公告)日：2014-03-05
申请号：EP10180398.9
申请日：2005-05-26
申请人： Crucell Holland B.V.
发明人： Bakker, Alexander, Berthold, Hendrik , Marissen, Willem Egbert , De Kruif, Cornelis Adriaan , Kramer, Robert Arjen
CPC分类号： C07K16/10 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N2760/20122 , G01N33/56983
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18.发明授权
公开(公告)号：EP2314620B1
公开(公告)日：2013-06-05
申请号：EP10180375.7
申请日：2005-05-26
申请人： Crucell Holland B.V.
发明人： Bakker, Alexander, Berthold, Hendrik , Marissen, Willem Egbert , Kramer, Robert Arjen , De Kruif, Cornelis Adriaan
CPC分类号： C07K16/10 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N2760/20122 , G01N33/56983
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公开(公告)号：EP2455398A2
公开(公告)日：2012-05-23
申请号：EP12153015.8
申请日：2007-09-06
申请人： Crucell Holland B.V.
IPC分类号： C07K16/10 , A61K39/145 , C12N5/10 , C12N15/09
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12N2760/16122
摘要： The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross-subtype protection in vivo , such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
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公开(公告)号：EP2450379A1
公开(公告)日：2012-05-09
申请号：EP12153013.3
申请日：2007-09-06
申请人： Crucell Holland B.V.
IPC分类号： C07K16/10 , A61K39/145 , C12N5/10 , C12N15/09
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12N2760/16122
摘要： The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross-subtype protection in vivo , such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
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