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公开(公告)号：EP3676267A1
公开(公告)日：2020-07-08
申请号：EP18850422.9
申请日：2018-08-31
发明人： HATCHER, John M. , GRAY, Nathanael S. , DE CLERCQ, Dries , JANG, Jaeborg , JANNE, Pasi , SAXON, Jamie A. , ECK, Michael , SCOTT, David A. , VERANO, Alyssa
IPC分类号： C07D471/04 , C07D487/04 , A61P35/00
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12.发明公开
公开(公告)号：EP3528814A1
公开(公告)日：2019-08-28
申请号：EP17862888.9
申请日：2017-10-18
IPC分类号： A61K31/519 , A61K31/551 , A61K31/5513 , C07D487/02 , C07D487/14 , C07D223/18
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公开(公告)号：EP3353150A1
公开(公告)日：2018-08-01
申请号：EP16849655.2
申请日：2016-09-23
IPC分类号： C07D209/56 , C07D413/14 , A61K31/403 , A61K31/5377
CPC分类号： C07D209/80 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C12N9/12 , C12N9/96 , C12Y207/11001
摘要： which modulates the activity of ALK or SRPK, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which ALK or SRPK plays a role.
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公开(公告)号：EP4153175A1
公开(公告)日：2023-03-29
申请号：EP21807757.6
申请日：2021-05-20
发明人： GRAY, Nathanael S. , FISCHER, Eric S. , VERANO, Alyssa , LIU, Hu , ZHANG, Tinghu , JONES, Lyn H. , WANG, Eric S. , NOWAK, Radoslaw , CHE, Jianwei
IPC分类号： A61K31/445 , A61K31/454 , B65D51/28
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公开(公告)号：EP4121046A1
公开(公告)日：2023-01-25
申请号：EP21771391.6
申请日：2021-03-17
发明人： FERGUSON, Fleur M. , GRAY, Nathanael S. , HAGGARTY, Stephen J. , TELO BAPTISTA LIMA DA SILVA, Maria Catarina
IPC分类号： A61K31/4166 , A61K31/495 , A61K31/381
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公开(公告)号：EP4047001A3
公开(公告)日：2022-11-30
申请号：EP21218204.2
申请日：2017-07-05
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
发明人： GRAY, Nathanael S. , LIANG, Yanke , CHOI, Hwan Geun , SUNDBERG, Thomas , SHAMJI, Alykhan , XAVIER, Ramnik , FISHER, David E. , MUJAHID, Nisma
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P7/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P37/00
摘要： The present disclosure provides compounds of Formula ( I ), ( II ), and ( III ). The provided compounds are able to bind protein kinases ( e . g ., SIK) and may be useful in modulating ( e.g., inhibiting) the activity of a protein kinase ( e.g., SIK, ( e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease ( e . g ., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.
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公开(公告)号：EP4065111A1
公开(公告)日：2022-10-05
申请号：EP20893666.6
申请日：2020-11-25
IPC分类号： A61K31/437 , C07D471/04 , C07D401/14
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公开(公告)号：EP4010336A1
公开(公告)日：2022-06-15
申请号：EP20849357.7
申请日：2020-08-04
发明人： DU, Guangyan , GRAY, Nathanael S. , ZHANG, Tinghu , HE, Zhixiang , KWIATKOWSKI, Nicholas , JIANG, Jie
IPC分类号： C07D403/04 , C07D513/04 , A61K31/635
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公开(公告)号：EP3986406A1
公开(公告)日：2022-04-27
申请号：EP20825844.2
申请日：2020-06-19
发明人： CULLIS, Courtney A. , GIPSON, Krista E. , HU, Yongbo , HUANG, Shih-Chung , GRAY, Nathanael S. , SCOTT, David A. , GERO, Thomas , ECK, Michael , HEPPNER, David , BEYETT, Tyler , TO, Ciric
IPC分类号： A61K31/496 , A61K31/506 , A61P35/00
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公开(公告)号：EP3968990A1
公开(公告)日：2022-03-23
申请号：EP20804945.2
申请日：2020-05-15
发明人： GRAY, Nathanael S. , HATCHER, John , CHOI, Jieun , LEE, Sun-Hwa , CHOI, Hwangeun , KO, Eunhwa , KIM, Yeonsil , KIM, Daekwon , KIM, Namdoo , SON, Jungbeom
IPC分类号： A61K31/437 , C07D487/04 , A61P25/28
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