公开(公告)号：EP2280084A1

公开(公告)日：2011-02-02

申请号：EP10177053.5

申请日：2005-12-02

申请人： Epigenomics AG

发明人： Cottrell, Susan ,  Model, Fabian ,  Haefliger, Carolina ,  Weiss, Gunter ,  Distler, Jürgen ,  Sledziewski, Andrew Z. ,  Song, Xiaoling ,  Skillman, Thomas L. ,  Thomas, Jeffrey G.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57434 ,  G01N2800/60

摘要： Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.

公开(公告)号：EP2213749A1

公开(公告)日：2010-08-04

申请号：EP09010002.5

申请日：2005-12-02

申请人： Epigenomics AG

发明人： Cottrell, Susan ,  Model, Fabian ,  Haefliger, Carolina ,  Weiss, Gunter ,  Distler, Jürgen ,  Sledziewski, Andrew Z. ,  Song, Xiaoling ,  Skillman, Thomas L. ,  Thomas, Jeffrey G.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57434 ,  G01N2800/60

摘要： Particular aspects provide novel methods and compositions ( e . g ., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.

摘要翻译： 特定方面提供了具有用于提供前列腺细胞增殖性病症的预后实质效用的新方法和组合物（例如G.，核酸，试剂盒等）。 在具体的方面，这是通过基因，或其子集的组的表达状态的分析来实现的。

公开(公告)号：EP3101141A3

公开(公告)日：2017-01-11

申请号：EP16163841.6

申请日：2008-06-06

申请人： Epigenomics AG

发明人： Devos, Theo ,  Lofton-Day, Cathy ,  Sledziewski, Andrew Z. ,  Model, Fabian ,  Krouse, Michael ,  Schuster, Matthias ,  Distler, Jürgen ,  Tetzner, Reimo ,  Ho, Jesse

IPC分类号： C12Q1/68

摘要： Aspects of the invention relate to composition and methods for the providing of DNA for methylation analysis that is in particular suitable to be applied in reference laboratories. Further aspects of the invention relate to composition and methods for the highly specific and sensitive methylation analysis of the Septin 9 gene also in particular suitable to be applied in reference laboratories.

公开(公告)号：EP2354250A1

公开(公告)日：2011-08-10

申请号：EP10174701.2

申请日：2004-06-23

申请人： Epigenomics AG

发明人： Lofton-Day, Cathy ,  Model, Fabian ,  Sledziewski, Andrew ,  Rujan, Tamas ,  Lewin, Jörn ,  Distler, Jürgen

IPC分类号： C12Q1/68 ,  C07H21/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

摘要翻译： 本发明提供了用于检测或检测和区分结肠直肠细胞增殖性病症或之间的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别之间的检测和分化，从而使得改善的患者诊断和治疗成为可能。

公开(公告)号：EP2345745A1

公开(公告)日：2011-07-20

申请号：EP10174719.4

申请日：2004-06-23

申请人： Epigenomics AG

发明人： Lofton-Day, Cathy ,  Model, Fabian ,  Sledziewski, Andrew ,  Rujan, Tamas ,  Lewin, Jörn ,  Distler, Jürgen

IPC分类号： C12Q1/68 ,  C07H21/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

公开(公告)号：EP2284279A1

公开(公告)日：2011-02-16

申请号：EP10177065.9

申请日：2005-12-02

申请人： Epigenomics AG

发明人： Cottrell, Susan ,  Model, Fabian ,  Haefliger, Carolina ,  Weiss, Gunter ,  Distler, Jürgen ,  Sledziewski, Andrew Z. ,  Song, Xiaoling ,  Skillman, Thomas L. ,  Thomas, Jeffrey G.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57434 ,  G01N2800/60

摘要： Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.

摘要翻译： 具体方面提供了具有提供前列腺细胞增殖性疾病预后的实质效用的新方法和组合物（例如，核酸，试剂盒等）。 在特定方面，这通过分析一组基因或其子集的表达状态来实现。

公开(公告)号：EP2009115A3

公开(公告)日：2009-02-25

申请号：EP08013800.1

申请日：2006-04-18

申请人： Epigenomics AG

发明人： Lofton-Day, Catherine ,  Sledziewski, Andrew ,  Lesche, Ralf ,  Schuster, Matthias ,  Distler, Jürgen ,  Tetzner, Reimo ,  Hildmann, Thomas ,  Model, Fabian ,  Song, Xiaoling

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6806 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/158

摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

公开(公告)号：EP2009115A2

公开(公告)日：2008-12-31

申请号：EP08013800.1

申请日：2006-04-18

申请人： Epigenomics AG

发明人： Lofton-Day, Catherine ,  Sledziewski, Andrew ,  Lesche, Ralf ,  Schuster, Matthias ,  Distler, Jürgen ,  Tetzner, Reimo ,  Hildmann, Thomas ,  Model, Fabian ,  Song, Xiaoling

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6806 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/158

摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

摘要翻译： 本发明提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之间的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。

公开(公告)号：EP3101141B1

公开(公告)日：2019-10-16

申请号：EP16163841.6

申请日：2008-06-06

申请人： Epigenomics AG

发明人： Devos, Theo ,  Lofton-Day, Cathy ,  Sledziewski, Andrew Z. ,  Model, Fabian ,  Krouse, Michael ,  Schuster, Matthias ,  Distler, Jürgen ,  Tetzner, Reimo ,  Ho, Jesse

IPC分类号： C12Q1/68

公开(公告)号：EP2634265B1

公开(公告)日：2016-09-14

申请号：EP13154539.4

申请日：2007-07-23

申请人： Epigenomics AG

发明人： Lofton-Day, Catherine ,  Sledziewski, Andrew ,  Model, Fabian ,  Cottrell, Susan ,  Distler, Jürgen ,  Tetzner, Reimo ,  Dietrich, Dimo

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/154