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1.发明授权Methods and nucleic acids related to the gene GLI3 for analyses of cellular proliferative disorders 有权与该基因GLI3的方法和核酸用于疾病与增殖细胞的生长相关联的分析相关联的
公开(公告)号：EP2634264B1
公开(公告)日：2016-09-14
申请号：EP13154538.6
申请日：2007-07-23
申请人： Epigenomics AG
发明人： Lofton-Day, Catherine , Sledziewski, Andrew , Model, Fabian , Cottrell, Susan , Distler, Jürgen , Tetzner, Reimo , Dietrich, Dimo
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/154
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公开(公告)号：EP2258871B1
公开(公告)日：2014-05-14
申请号：EP10156846.7
申请日：2008-01-18
申请人： Epigenomics AG
发明人： Liebenberg, Volker , Distler, Jürgen , Lewin, Jörn , Model, Fabian , Tetzner, Reimo , Cortese, Rene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
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3.发明公开Methods and nucleic acids related to the gene GLI3 for analyses of cellular proliferative disorders 有权Mit dem Gen GLI3 assozierte Verfahrenfürdie Detektion von kolorektalem Karzinom
公开(公告)号：EP2634265A1
公开(公告)日：2013-09-04
申请号：EP13154539.4
申请日：2007-07-23
申请人： Epigenomics AG
发明人： Lofton-Day, Catherine , Sledziewski, Andrew , Model, Fabian , Cottrell, Susan , Distler, Jürgen , Tetzner, Reimo , Dietrich, Dimo
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： The invention provides methods, nucleic acids and kits for detecting colorectal cell proliferative disorders. The invention discloses genomic sequences of the gene GLI3 the methylation patterns of which have utility for the improved detection of said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供了用于检测结肠直肠细胞增殖性疾病的方法，核酸和试剂盒。 本发明公开了基因GLI3的基因组序列，其甲基化模式可用于改善所述疾病类别的检测，从而能够改善患者的诊断和治疗。
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4.发明公开Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders 审中-公开方法和核酸前列腺细胞的增殖的病症的预测的相关联的基因表达进行分析
公开(公告)号：EP2311984A1
公开(公告)日：2011-04-20
申请号：EP10177084.0
申请日：2005-12-02
申请人： Epigenomics AG
发明人： Cottrell, Susan , Model, Fabian , Haefliger, Carolina , Weiss, Gunter , Distler, Jürgen , Sledziewski, Andrew Z. , Song, Xiaoling , Skillman, Thomas L. , Thomas, Jeffrey G.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , G01N33/57434 , G01N2800/60
摘要： Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.
摘要翻译： 特定方面提供新颖的方法和具有用于提供前列腺细胞增殖性病症的预后实质效用组合物（例如，核酸，试剂盒等）。 在具体的方面，这是通过基因，或其子集的组的表达状态的分析来实现的。
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5.发明公开Methods and nucleic acids for analyses of cell proliferative disorders 有权Verfahren undNukleinsäurenzur分析von zellproliferativen Krankheiten
公开(公告)号：EP2258871A1
公开(公告)日：2010-12-08
申请号：EP10156846.7
申请日：2008-01-18
申请人： Epigenomics AG
发明人： Liebenberg, Volker , Distler, Jürgen , Lewin, Jörn , Model, Fabian , Tetzner, Reimo , Cortese, Rene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： The invention provides methods, nucleic acids and kits for detecting cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测细胞增殖性疾病的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述病症的检测，从而能够改善患者的诊断和治疗。
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6.发明公开Methods and nucleic acids for analyses of cellular proliferative disorders 有权Verfahrenfürdie分析von Zellwucher-Störungen
公开(公告)号：EP2045335A1
公开(公告)日：2009-04-08
申请号：EP08021839.9
申请日：2006-04-17
申请人： Epigenomics AG
发明人： Distler, Jürgen , Hildmann, Thomas , Lesche, Ralf , Lofton-Day, Cathy , Model, Fabian , Schuster, Matthias , Sledziewski, Andrew , Song, Xiaoling , Tetzner, Reimo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之间的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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公开(公告)号：EP3101141A2
公开(公告)日：2016-12-07
申请号：EP16163841.6
申请日：2008-06-06
申请人： Epigenomics AG
发明人： Devos, Theo , Lofton-Day, Cathy , Sledziewski, Andrew Z. , Model, Fabian , Krouse, Michael , Schuster, Matthias , Distler, Jürgen , Tetzner, Reimo , Ho, Jesse
IPC分类号： C12Q1/68
摘要： Aspects of the invention relate to composition and methods for the providing of DNA for methylation analysis that is in particular suitable to be applied in reference laboratories. Further aspects of the invention relate to composition and methods for the highly specific and sensitive methylation analysis of the Septin 9 gene also in particular suitable to be applied in reference laboratories.
摘要翻译： 本发明的方面涉及提供用于甲基化分析的DNA的组合物和方法，其特别适用于参考实验室。 本发明的其它方面涉及用于Septin 9基因的高度特异性和敏感的甲基化分析的组合物和方法，特别适用于参考实验室。
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8.发明授权Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders 有权方法和核酸前列腺细胞的增殖的病症的预测的相关联的基因表达进行分析
公开(公告)号：EP2280084B1
公开(公告)日：2015-02-11
申请号：EP10177053.5
申请日：2005-12-02
申请人： Epigenomics AG
发明人： Cottrell, Susan , Model, Fabian , Haefliger, Carolina , Weiss, Gunter , Distler, Jürgen , Sledziewski, Andrew Z. , Song, Xiaoling , Skillman, Thomas L. , Thomas, Jeffrey G.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , G01N33/57434 , G01N2800/60
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9.发明公开Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders 审中-公开方法和核酸前列腺细胞的增殖的病症的预测的相关联的基因表达进行分析
公开(公告)号：EP2311984A8
公开(公告)日：2011-12-28
申请号：EP10177084.0
申请日：2005-12-02
申请人： Epigenomics AG
发明人： Cottrell, Susan , Model, Fabian , Haefliger, Carolina , Weiss, Gunter , Distler, Jürgen , Sledziewski, Andrew Z. , Song, Xiaoling , Skillman, Thomas L. , Thomas, Jeffrey G.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , G01N33/57434 , G01N2800/60
摘要： Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.
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10.发明公开Methods and nucleic acids for analyses of cell proliferative disorders 审中-公开Verfahren undNukleinsäurenfürAnalysen von Zellwucher-Störungen
公开(公告)号：EP2302069A1
公开(公告)日：2011-03-30
申请号：EP10008955.6
申请日：2008-12-11
申请人： Epigenomics AG
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： The invention provides methods, nucleic acids and kits for detecting lung carcinoma. The invention discloses genomic FOXL2 sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测肺癌的方法，核酸和试剂盒。 本发明公开了基因组FOXL2序列，其甲基化模式可用于改善所述病症的检测，从而能够改善患者的诊断和治疗。
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