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1.发明公开METHOD FOR THE DETERMINATION OF THE DNA METHYLATION LEVEL OF A CPG POSITION IN IDENTICAL CELLS WITHIN A TISSUE SAMPLE 审中-公开VERFAHREN ZUR BESTIMMUNG DES DNA-METHYLIERUNGSGRADS EINER CPG-POSITION IN IDENTISCHEN ZELLEN IN EINER GEWEBEPROBE
公开(公告)号：EP3095878A1
公开(公告)日：2016-11-23
申请号：EP16163903.4
申请日：2006-11-17
申请人： Epigenomics AG
发明人： Lewin, Jörn , Berlin, Kurt
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： Aspects of the present invention relate to the determination of the DNA methylation level at one or more CpG position within cells of a defined type in a tissue sample. This methylation level is deduced from the total DNA methylation level of all cells of the sample and from the content of said cells of interest. In aspects of the invention, the cell content is determined by means of histopatholoy, staining methods, antibodies, expression analysis or DNA methylation analysis.
摘要翻译： 本发明的方面涉及在组织样品中限定类型的细胞内的一个或多个CpG位置处的DNA甲基化水平的确定。 该甲基化水平是从样品的所有细胞的总DNA甲基化水平以及所述感兴趣的细胞的含量推断的。 在本发明的方面，通过组织病理学，染色方法，抗体，表达分析或DNA甲基化分析来确定细胞含量。
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2.发明公开Methods and nucleic acids for analyses of colorectal cell proliferative disorders 审中-公开Verfahren undNukleinsäurenzur分析vonStörungender Proliferation kolorektaler Zellen
公开(公告)号：EP2354249A1
公开(公告)日：2011-08-10
申请号：EP10174640.2
申请日：2004-06-23
申请人： Epigenomics AG
发明人： Lofton-Day, Cathy , Model, Fabian , Sledziewski, Andrew , Rujan, Tamas , Lewin, Jörn , Distler, Jürgen
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测或检测和区分结肠直肠细胞增殖性疾病或其中的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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公开(公告)号：EP2354248B1
公开(公告)日：2018-01-03
申请号：EP10174462.1
申请日：2004-06-23
申请人： Epigenomics AG
发明人： Lofton-Day, Cathy , Model, Fabian , Sledziewski, Andrew , Rujan, Tamas , Lewin, Jörn , Distler, Jürgen
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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4.发明公开Methods and nucleic acids for analyses of colorectal cell proliferative disorders 有权Verfahren zur分析vonStörungender Proliferation kolorektaler Zellen
公开(公告)号：EP2354248A1
公开(公告)日：2011-08-10
申请号：EP10174462.1
申请日：2004-06-23
申请人： Epigenomics AG
发明人： Lofton-Day, Cathy , Model, Fabian , Sledziewski, Andrew , Rujan, Tamas , Lewin, Jörn , Distler Jürgen
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测或检测和区分结肠直肠细胞增殖性疾病或其中的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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公开(公告)号：EP2258871B1
公开(公告)日：2014-05-14
申请号：EP10156846.7
申请日：2008-01-18
申请人： Epigenomics AG
发明人： Liebenberg, Volker , Distler, Jürgen , Lewin, Jörn , Model, Fabian , Tetzner, Reimo , Cortese, Rene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
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6.发明公开Methods and nucleic acids for analyses of cell proliferative disorders 有权Verfahren undNukleinsäurenzur分析von zellproliferativen Krankheiten
公开(公告)号：EP2258871A1
公开(公告)日：2010-12-08
申请号：EP10156846.7
申请日：2008-01-18
申请人： Epigenomics AG
发明人： Liebenberg, Volker , Distler, Jürgen , Lewin, Jörn , Model, Fabian , Tetzner, Reimo , Cortese, Rene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： The invention provides methods, nucleic acids and kits for detecting cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测细胞增殖性疾病的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述病症的检测，从而能够改善患者的诊断和治疗。
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7.发明授权Methods and nucleic acids for the analysis of CpG methylation associated with the development of prostate cell proliferative disorders 有权方法和核酸对CpG甲基化的分析，伴随着前列腺的与指定的细胞增殖性疾病相关的发展
公开(公告)号：EP2261366B1
公开(公告)日：2016-01-27
申请号：EP10006026.8
申请日：2008-11-11
申请人： Epigenomics AG
发明人： Sledziewski, Andrew , Payne, Shannon , Schuster, Matthias , Lewin, Jörn , Schlegel, Thomas , Morotti, Andrew M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158
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8.发明公开Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders 有权方法和核酸对CpG甲基化的分析，伴随着前列腺的与指定的细胞增殖性疾病相关的发展
公开(公告)号：EP2261366A1
公开(公告)日：2010-12-15
申请号：EP10006026.8
申请日：2008-11-11
申请人： Epigenomics AG
发明人： Sledziewski, Andrew , Payne, Shannon , Schuster, Matthias , Lewin, Jörn , Schlegel, Thomas , Morotti, Andrew M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158
摘要： The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The.invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
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公开(公告)号：EP3828281A1
公开(公告)日：2021-06-02
申请号：EP20214665.0
申请日：2017-01-27
申请人： Epigenomics AG
发明人： Lewin, Jörn , Kottwitz, Denise , Esche, Selina
IPC分类号： C12Q1/68
摘要： The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of methylated ANKRD13B and/or FOXF2 DNA derived from a tumor in blood or blood-derived samples or in other body fluids that contain DNA released from a tumor. This detection is useful for a minimally invasive diagnosis of cancers and the invention provides methods and oligonucleotides suitable for this purpose.
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10.发明公开Methods and nucleic acids for analyses of colorectal cell proliferative disorders 审中-公开用于分析结肠直肠细胞增殖性疾病的方法和核酸
公开(公告)号：EP2354250A1
公开(公告)日：2011-08-10
申请号：EP10174701.2
申请日：2004-06-23
申请人： Epigenomics AG
发明人： Lofton-Day, Cathy , Model, Fabian , Sledziewski, Andrew , Rujan, Tamas , Lewin, Jörn , Distler, Jürgen
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供了用于检测或检测和区分结肠直肠细胞增殖性病症或之间的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别之间的检测和分化，从而使得改善的患者诊断和治疗成为可能。
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