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17 条记录 (耗时 0.015 秒)

    A new compound, FR-900451, production and use thereof
    15.
    发明公开
    A new compound, FR-900451, production and use thereof 失效
    Verbindung FR-900451，deren Herstellung und Anwendung。

    公开(公告)号：EP0144238A2

    公开(公告)日：1985-06-12

    申请号：EP84308424.5

    申请日：1984-12-04

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Ezaki, Masami ,  Hashimoto, Seiji ,  Komori, Tadaaki ,  Umehara, Kazuyoshi ,  Kohsaka, Masanobu

    IPC分类号： C07G11/00 ,  C12P1/06 ,  A61K35/66 ,  C12N1/20

    CPC分类号： C12P1/06 ,  C12R1/465 ,  Y10S435/886

    摘要： The invention relates to a new compound, designated FR-900451, and pharmaceutically acceptable salts thereof. The compound has antimicrobial properties and is effective in the treatment of various infectious diseases in both human beings and animals.
    There is also provided a process for preparing FR-900451 compound which comprises culturing a FR-900451 producing strain belonging to the genus Streptomyces in a nutrient medium.
    Pharmaceutical compositions comprising FR-900451 as an active ingredient are also described.

    摘要翻译： 本发明涉及一种名为FR-900451的新化合物及其药学上可接受的盐。 该化合物具有抗微生物特性，在人和动物的各种感染性疾病的治疗中都是有效的。 还提供了制备FR-900451化合物的方法，其包括在营养培养基中培养属于链霉菌属的FR-900451产生菌株。 还描述了包含FR-900451作为活性成分的药物组合物。

    N-acyl peptide, processes for their preparation and pharmaceutical compostions thereof
    16.
    发明公开
    N-acyl peptide, processes for their preparation and pharmaceutical compostions thereof 失效
    N-Acyl Peptiden，Verfahren zu deren Herstellung und deren pharmazeutische Zusammensetzungen。

    公开(公告)号：EP0085255A2

    公开(公告)日：1983-08-10

    申请号：EP82306928.1

    申请日：1982-12-23

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Umehara, Kazuyoshi ,  Yoshida, Keizo ,  Tanaka, Hirokazu ,  Uchida, Itsuo ,  Kohsaka, Masanobu ,  Imanaka, Hiroshi

    IPC分类号： C07K5/06 ,  C07K5/08

    CPC分类号： C07K5/06104 ,  A61K38/00 ,  C07K5/06052 ,  C07K5/06078 ,  C07K5/06086

    摘要： Compounds of the formula:
    wherein

    R 1 is hydrogen, alkanoyloxy or alkenoyloxy;
    R 2 is alkyl or alkenyl;
    R 3 and R 4 are each hydrogen, lower alkyl, hydroxy(lower)alkyl, ar(lower) alkyl, esterified carboxy(lower)alkyl, carboxy-(lower)alkyl, protected amino(lower)alkyl or amino(lower)alkyl;
    R 5 is hydrogen, hydroxy(lower)alkyl, protected amino-(lower)alkyl, amino(lower)alkyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl;
    R 6 is carboxy, esterifed carboxy or sulfo(lower)alkyl;
    A 1 , A 2 and A3 are each bond or lower alkylene; and m and n are each an integer of 0 or 1; and their pharmaceutically- acceptable salts have anti-complementary activity and fibrinolytic activity, and are useful as therapeutic agents for immunecomplex diseases or autoimmune diseases such as nephritis, rheumatic diseases, systemic lupus erythematosus, etc. and thrombosis such as cerebral apoplexy, coronary insufficiency, pulmonary embolism.

    摘要翻译： 其中R 1是氢，烷酰氧基或烯酰基氧基; R 2是烷基或链烯基; R 3和R 4分别是氢，低级烷基， 羟基（低级）烷基，芳基（低级）烷基，酯化羧基（低级）烷基，羧基（低级）烷基，受保护的氨基（低级）烷基或氨基（低级）烷基; 烷基，保护的氨基（低级）烷基，氨基（低级）烷基，羧基（低级）烷基或酯化的羧基（低级）烷基; R 6是羧基，酯化的羧基或磺基（低级）烷基; A 2和A 3各自为键或低级亚烷基; m和n分别为0或1的整数; 其药学上可接受的盐具有抗互补活性和纤维蛋白溶解活性，并且可用作免疫复合疾病或自身免疫疾病如肾炎，风湿性疾病，系统性红斑狼疮等的治疗剂，以及血栓形成如脑中风，冠状动脉功能不全， 肺栓塞。

    N-acyl peptide compounds, processes for the preparation thereof and pharmaceutical compositions containing them
    17.
    发明公开
    N-acyl peptide compounds, processes for the preparation thereof and pharmaceutical compositions containing them 失效
    N-酰基肽化合物，它们的制备方法和含有它们的药物组合物。

    公开(公告)号：EP0054435A1

    公开(公告)日：1982-06-23

    申请号：EP81305887.2

    申请日：1981-12-15

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Umehara, Kazuyoshi ,  Uchida, Itsuo ,  Kohsaka, Masanobu ,  Imanaka, Hiroshi ,  Yoshida, Keizo

    IPC分类号： C07C103/52 ,  C07C103/167 ,  C07C103/173 ,  C07C103/18 ,  C12P21/02 ,  C12R1/20 ,  A61K37/02

    CPC分类号： C07K5/06026 ,  A61K38/00

    摘要： The N-acylpeptide compounds are represented by the general formula:-
    wherein R 1 and R 2 are each alkyl or alkenyl;

    R 3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, heterocyclic(lower)alkyl or ar(lower)alkyl, wherein the aryl moiety may have hydroxy or protected hydroxy;
    R 4 is carboxy, esterified carboxy, carboxy(lower)alkyl or esterified carboxy(lower)alkyl;
    X is a bond or lower alkylene;
    Y is lower alkylene or lower alkylidene and n is 0 or 1; and including their pharmaceutically acceptable salts.

    These compounds are useful as therapeutic agents in the treatment of immune-complex or autoimmune diseases.

    摘要翻译： N-酰基肽化合物由以下通式表示： - ... ... worin - [R <1>和R <2>各自为烷基或链烯基; ... [R <3>是氢，低级烷基，羟基（低级）烷基 ，杂环（低级）烷基或芳基（低级）烷基，worin芳基部分可以具有羟基或保护的羟基; ... [R <4>是羧基，酯化的羧基，羧基（低级）烷基或酯化的羧基（低级）烷基; ... X 是一个键或低级亚烷基; ... Y是低级亚烷基或低级亚烷基，n是0或1; 和药学上可接受的盐包括其。 ... 这些化合物可用作在免疫复合物或自体免疫疾病的治疗中的治疗剂是有用的。