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公开(公告)号：EP0336230B1
公开(公告)日：1997-02-12
申请号：EP89105225.0
申请日：1989-03-23
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公开(公告)号：EP0327009B1
公开(公告)日：1994-07-13
申请号：EP89101607.3
申请日：1989-01-31
发明人： Kino, Tohru , Nishikawa, Motoaki , Ezaki, Masami , Kiyoto, Sumio , Okuhara, Masakuni , Takase, Shigehiro , Okada, Satoshi , Shigematsu, Nobuharu
摘要： This application relates to new compounds called WS-9326A, WS-9326B, and their derivatives having valuable pharmaceutical properties and which are obtainable by culturing a WS-9326A and/or WS-9326B producing strain belonging to the genus Streptomyces in nutrient medium and recovering such compounds or salts thereof from the resultant cultured broth. The invention also relates to a process for the production of such compounds and to pharmaceutical compositions containing them or a pharmaceutically acceptable salt thereof as an active ingredient. The invention furthermore relates to a biologically pure culture of the microorgnism Streptomyces violaceoniger No. 9326 (FERM BP-1667).
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公开(公告)号：EP0336230A3
公开(公告)日：1991-07-17
申请号：EP89105225.0
申请日：1989-03-23
发明人： Kino, Tohru , Nishikawa, Motoaki , Ezaki, Masami , Kiyoto, Sumio , Okuhara, Masakuni , Takase, Shigehiro , Okada, Satoshi , Shigematsu, Nobuharu
摘要： A compound of the formula wherein the symbols define certain groups or atoms, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also comprises a biologically pure culture of the microorganism Streptomyces violaceoniger No. 9326 (FERM BP-1667).
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4.发明授权A prophylactic/therapeutic composition containing WS7622A for preventing or treating disseminated intravascular coagulation, chronic respiratory tract infectious disease or chronic bronchitis 失效含有用于预防和预防/治疗组合物治疗弥散性血管内凝血，慢性的，感染性的呼吸系统疾病或慢性支气管炎WS7622A
公开(公告)号：EP0519354B1
公开(公告)日：1997-12-10
申请号：EP92109970.1
申请日：1992-06-13
发明人： Inamura, Noriaki , Shingu, Yasuhiko , Nakahara, Kunio , Notsu, Yoshitada , Okamoto, Masanori , Takase, Shigehiro , Hatanaka, Hiroshi , Ezaki, Masami , Tsujii, Eisaku , Shigematsu, Nobuharu , Okuhara, Masakuni
CPC分类号： C07K4/04 , A61K38/00 , A61K39/00 , C07K14/811
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5.发明授权WS 7622 A,B,C and D substances, derivatives thereof, processes for preparation thereof and use thereof 失效WS 7622种物质A，B，C和D，它们的衍生物，它们的制备方法和它们的用途。
公开(公告)号：EP0387712B1
公开(公告)日：1995-06-07
申请号：EP90104500.5
申请日：1990-03-09
发明人： Hatanaka, Hiroshi , Ezaki, Masami , Tsujii, Eisaku , Okamoto, Masanori , Shigematsu, Nobuharu , Okuhara, Masakuni , Takase, Shigehiro
CPC分类号： C12P1/06 , C12R1/465 , Y10S435/886
摘要： A biologically pure culture of Streptomyces resistomycificus No. 7622 (FERM BP-2306), new compounds WS7622A, B, C and D obtainable by culturing Streptomyces resistomycificus No. 7622 in a nutrient medium and isolating them or their pharmaceutically acceptable salts, and derivatives of such new compounds, and pharmaceutical compositions comprising such new compounds or their pharmaceutically acceptable salts as an active ingredient.
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6.发明公开FR-900493 substance, a process for its production and a pharmaceutical composition containing the same 失效FR-900493物质，其生产方法和含有该物质的药物组合物
公开(公告)号：EP0333177A3
公开(公告)日：1990-04-04
申请号：EP89104621.1
申请日：1989-03-15
发明人： Ochi, Kozo , Ezaki, Masami , Iwani, Morita , Komori, Tadaaki , Kohsaka, Masanobu
CPC分类号： C12P1/04 , C12R1/085 , Y10S435/834
摘要： A new antimicrobial agent called FR-900493 obtainable by culturing a FR-900493 substance-producing strain belonging to the genus Bacillus in nutrient medium and recovering the FR-900493 substance, and a process for preparing FR-900493 by such cultivation. The invention further comprises pharmaceutical compositions contain- ling FR-900493 substance as an active ingredient in association with a pharmaceutically acceptable, substantially pon-toxic carrier or excipient. The invention also covers a biologically pure culture of the microorganism Bacillus cereus No. 2045 (FERM BP-1791).
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公开(公告)号：EP0336230A2
公开(公告)日：1989-10-11
申请号：EP89105225.0
申请日：1989-03-23
发明人： Kino, Tohru , Nishikawa, Motoaki , Ezaki, Masami , Kiyoto, Sumio , Okuhara, Masakuni , Takase, Shigehiro , Okada, Satoshi , Shigematsu, Nobuharu
摘要： A compound of the formula
wherein the symbols define certain groups or atoms, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also comprises a biologically pure culture of the microorganism Streptomyces violaceoniger No. 9326 (FERM BP-1667).摘要翻译： 式CHEM的化合物，其中符号定义某些基团或原子，其制备方法和药物组合物，其包含它们作为与药学上可接受的，基本上无毒的载体或赋形剂相结合的活性成分。 本发明还包括微生物链霉菌9326菌株（FERM BP-1667）的生物学纯培养物。
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公开(公告)号：EP0144238A3
公开(公告)日：1986-10-22
申请号：EP84308424
申请日：1984-12-04
IPC分类号： C07G11/00 , C12P01/06 , A61K35/66 , C12N01/20 , C12R01/465
CPC分类号： C12P1/06 , C12R1/465 , Y10S435/886
摘要： The invention relates to a new compound, designated FR-900451, and pharmaceutically acceptable salts thereof. The compound has antimicrobial properties and is effective in the treatment of various infectious diseases in both human beings and animals. There is also provided a process for preparing FR-900451 compound which comprises culturing a FR-900451 producing strain belonging to the genus Streptomyces in a nutrient medium. Pharmaceutical compositions comprising FR-900451 as an active ingredient are also described.
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9.发明公开A new antimicrobial agent, fr 109615 and production thereof 无效Antimikrobielles Agens，FR 109 615 und seine Herstellung。
公开(公告)号：EP0298640A1
公开(公告)日：1989-01-11
申请号：EP88305828.1
申请日：1988-06-27
IPC分类号： A61K35/66 , A61K31/395 , C12P1/06 , C07C229/36
摘要： The invention relates to a new anti-microbial compound, designated FR109615, having the characteristics and physico-chemical properties described herein. The compound shows anti-microbial activity against pathogenic microorganisms, especially pathogenic fungi, and is useful for the treatment of various infectious diseases in both human beings and animals.
There is provided a process for preparing the FR109615 compound which comprises culturing a FR109615 producing strain belonging to the genus Steptomyces in a nutrient medium.
Pharmaceutical compositions comprising FR109615 as an active ingredient are also described.摘要翻译： 本发明涉及具有本文所述的特征和物理化学性质的新的抗微生物化合物FR109615。 该化合物对致病微生物，特别是致病真菌显示抗微生物活性，并且可用于治疗人和动物中的各种感染性疾病。 提供了一种制备FR109615化合物的方法，其包括在营养培养基中培养属于Steptomyces属的FR109615产生菌株。 还描述了包含FR109615作为活性成分的药物组合物。
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10.发明公开Amino acid derivatives, process for the preparation thereof and pharmaceutical composition comprising the same 失效氨基酸衍生物，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0285085A2
公开(公告)日：1988-10-05
申请号：EP88105058.7
申请日：1988-03-29
发明人： Okuhara, Masakuni , Goto, Toshio , Ezaki, Masami , Tanaka, Miho , Takase, Shigehiro , Nakajima, Hidenori , Hirai, Hideo , Katayama, Akira
IPC分类号： C07C113/00 , C12P13/00 , A61K31/215
CPC分类号： C12P13/04 , C07C245/18 , C12P13/00 , Y10S435/886
摘要： An amino acid derivative of the formula:
in which
R¹ is hydrogen, lower alkyl, halo(lower)alkyl or aryl
R² is hydrogen, hydroxy or protected hydroxy,
R³ is hydrogen,
R⁴ is lower alkyl, amino(lower)alkyl, carboxy(lower)alkyl, aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected amino-carboxy(lower)alkyl,
R⁵ is hydrogen or lower alkyl, and
R² and R³ may combine to be oxo, and its pharmaceutical acceptable salt, having anti-tumor activity a process for preparation thereof and pharmaceutical compositions comprising the same.摘要翻译： 氢
其中R <1>是，低级烷基，卤代（低级）烷基或芳基 - [R <2>为氢，羟基或保护的羟基，R <3>是氢，R：下式的氨基酸衍生物 <4>被低级烷基，氨基（低级）烷基，羧基（低级）烷基，氨基羧基（低级）烷基，保护的氨基（低级）烷基或保护的氨基羧基（低级）烷基，R <5>是氢或低级烷基 和R <2>和R <3>可以组合成氧代基，和其药学上可接受的盐，其具有抗肿瘤活性的其制备和药物组合物包含相同的处理。
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