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11.发明授权Compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts 有权筛选试验化合物以诱导未分化的哺乳动物细胞的分化成成骨细胞
公开(公告)号：EP2259063B1
公开(公告)日：2012-05-23
申请号：EP10174527.1
申请日：2005-04-27
申请人： Galapagos N.V.
IPC分类号： G01N33/566 , A61P19/10 , G01N33/50
CPC分类号： G01N33/566 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/11 , C12N2320/12 , G01N33/5026 , G01N2333/51 , G01N2500/04 , G01N2800/108
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12.发明公开Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts 有权方法，试剂和筛选试验化合物用于感应未分化的哺乳动物细胞的分化成成骨细胞
公开(公告)号：EP2259063A3
公开(公告)日：2011-04-20
申请号：EP10174527.1
申请日：2005-04-27
申请人： Galapagos N.V.
IPC分类号： G01N33/566 , A61P19/10 , G01N33/50
CPC分类号： G01N33/566 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/11 , C12N2320/12 , G01N33/5026 , G01N2333/51 , G01N2500/04 , G01N2800/108
摘要： The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.
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