公开(公告)号：EP3275443A1

公开(公告)日：2018-01-31

申请号：EP17173155.7

申请日：2012-09-20

申请人： Exelixis, Inc.

发明人： AFTAB, Dana T. ,  CLARY, Douglas

IPC分类号： A61K31/47 ,  A61P19/10

CPC分类号： A61K31/47 ,  A61K9/2018 ,  A61K9/2054 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2333/916 ,  G01N2800/108 ,  G01N2800/52

摘要： This invention is directed to the treatment of osteoporosis using N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide.

摘要翻译： 本发明涉及用N-（4 - {[6,7-双（甲氧基）喹啉-4-基]氧基}苯基）-N' - （4-氟苯基）环丙烷-1,1-二氧化物治疗骨质疏松症， 二甲酰胺。

公开(公告)号：EP2586796B1

公开(公告)日：2016-12-07

申请号：EP13151551.2

申请日：2008-10-10

申请人： MEREO BIOPHARMA 3 LIMITED

发明人： Kneissel, Michaela ,  Halleux, Christine ,  Hu, Shou-Ih ,  Diefenbach-Streiber, Beate ,  Prassler, Josef

IPC分类号： C07K16/18 ,  C12N15/13 ,  C12N15/63 ,  A61K31/663 ,  A61K39/395 ,  G01N33/68 ,  A61K45/06 ,  A61K39/00

CPC分类号： G01N33/6854 ,  A61K31/663 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/51 ,  G01N2800/108 ,  A61K2300/00

公开(公告)号：EP2815241A2

公开(公告)日：2014-12-24

申请号：EP13749868.9

申请日：2013-02-15

申请人： BASF SE

发明人： WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WIEMER, Jan C ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  PROKOUDINE, Alexandre

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/5044 ,  G01N33/6806 ,  G01N33/84 ,  G01N33/92 ,  G01N2570/00 ,  G01N2800/108

摘要： The present invention pertains to the field of diagnostics for bone disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing a bone disorder, it also relates to a method for determining whether a compound is capable of inducing such a bone disorder in a subject and to a method of identifying a drug for treating a bone disorder. Furthermore, the present invention relates to a device and a kit for diagnosing a bone disorder.

公开(公告)号：EP2758057A1

公开(公告)日：2014-07-30

申请号：EP12770368.4

申请日：2012-09-20

申请人： Exelixis, Inc.

发明人： AFTAB, Dana, T. ,  CLARY, Douglas

IPC分类号： A61K31/47 ,  A61P19/10

CPC分类号： A61K31/47 ,  A61K9/2018 ,  A61K9/2054 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2333/916 ,  G01N2800/108 ,  G01N2800/52

摘要： This invention is directed to the treatment of osteoporosis using Ν-(4-{ [6,7- bis(methyloxy)quinolin-4-yI]oxy}ρhenyl)-N'-(4-fluorophenyl)cycIopropane-l,l-dicarboxamide.

摘要翻译： 本发明涉及使用N-（4 - {[6,7-双（甲氧基）喹啉-4-基]氧基}苯基）-N' - （4-氟苯基）环丙烷-1,1-二氧化物治疗骨质疏松症， 二甲酰胺。

公开(公告)号：EP2557179A4

公开(公告)日：2013-09-25

申请号：EP11766005

申请日：2011-04-08

申请人： YOSHITOMI HIROYUKI ,  MITSUBISHI CHEM MEDIENCE CORP ,  MURATA KOICHI

发明人： YOSHITOMI HIROYUKI ,  MURATA KOICHI

IPC分类号： C12Q1/68 ,  C12N15/09 ,  G01N33/50

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N2800/046 ,  G01N2800/065 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/108 ,  G01N2800/202 ,  G01N2800/24 ,  G01N2800/26 ,  G01N2800/285

公开(公告)号：EP2431738A1

公开(公告)日：2012-03-21

申请号：EP09844700.6

申请日：2009-12-01

申请人： Innopharmascreen Inc.

发明人： KANG, In-Cheol ,  KIM, Eung-Yoon ,  CHOI, Young-Jin

IPC分类号： G01N33/15 ,  G01N33/68 ,  G01N33/52

CPC分类号： G01N33/6893 ,  C07C50/32 ,  C07C2602/28 ,  C07D417/04 ,  G01N33/566 ,  G01N33/6845 ,  G01N2333/70557 ,  G01N2500/02 ,  G01N2800/108

摘要： Provided is a compound found by screening a material for inhibiting an osteopontin, in which the material for inhibiting the osteopontin can increase effectiveness as an excellent material for inhibiting an osteoporosis.

公开(公告)号：EP2419133A1

公开(公告)日：2012-02-22

申请号：EP10713931.3

申请日：2010-04-13

申请人： Deutsches Krebsforschungszentrum ,  Galapagos S.A.S.U.

发明人： RAWADI, Georges ,  NIEHRS, Christof

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P19/08

CPC分类号： C07K16/18 ,  A01K67/0276 ,  A01K2217/077 ,  A01K2227/105 ,  A01K2267/035 ,  C07K14/47 ,  C12N15/8509 ,  G01N33/6893 ,  G01N2800/10 ,  G01N2800/108

摘要： The present invention relates to uses of antagonists of Rspondin-3 (Rspo3) polypeptides or Rspondin-3 nucleic acids. The invention is based on the demonstration that partial deficiency of Rspo3 leads to a significant increase of bone mass. These results indicate a major role for Rspo3 as a bone anabolic marker or target. Thus, the invention also relates to the use of Rspo3 antagonists in the treatment of osteopenia disorders, particularly in conditions associated with increased bone resorption.

公开(公告)号：EP2389803A2

公开(公告)日：2011-11-30

申请号：EP11169483.2

申请日：2007-10-11

申请人： ORIENTAL YEAST CO., LTD.

发明人： Tomimori, Yoshiya ,  Yasuda, Hisataka

IPC分类号： A01K67/027 ,  A01K67/00 ,  G01N33/15 ,  G01N33/50 ,  C07K14/47

CPC分类号： C07K14/4705 ,  A01K2207/10 ,  A01K2227/105 ,  A01K2267/03 ,  C07K2319/23 ,  G01N33/5088 ,  G01N2333/70575 ,  G01N2800/108

摘要： The present invention provides a method for producing an osteopenia animal model by RANKL administration and an osteopenia animal model.
Also, a method for producing an osteopenia animal model, comprising administering, soluble RANKL or a fused protein of soluble RANKL with an epitope tag to a non-human animal so as to promote in vivo osteoclast differentiation and activation in the non-human animal, and an osteopenia animal model produced by the method are provided.

摘要翻译： 本发明提供了一种通过RANKL给药和骨质减少动物模型生产骨质减少症动物模型的方法。 另外，一种生产骨质减少症动物模型的方法，包括向非人动物施用可溶性RANKL或具有表位标签的可溶性RANKL融合蛋白，以促进非人动物体内破骨细胞分化和活化， 并提供通过该方法产生的骨质减少动物模型。

公开(公告)号：EP1989939B1

公开(公告)日：2011-07-13

申请号：EP06810983.4

申请日：2006-09-25

申请人： University of Miyazaki

发明人： IMAIZUMI, Kazunori ,  KONDO, Shinichi ,  WANAKA, Akio

IPC分类号： A01K67/027 ,  C12N15/09 ,  G01N33/15 ,  G01N33/50 ,  C07K14/47 ,  C12N15/85

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/035 ,  C07K14/4702 ,  C12N15/8509 ,  G01N33/5088 ,  G01N2800/108

摘要： A mouse that is deficient in the function of OASIS gene; and a method of efficacy estimation or screening for a therapeutic agent for osteoporosis in which use is made of the mouse.

公开(公告)号：EP2282756A1

公开(公告)日：2011-02-16

申请号：EP09728672.8

申请日：2009-03-30

申请人： The Trustees of Columbia University in the City of New York

发明人： KARSENTY, Gerard ,  DUCY, Patricia, F. ,  XIE, Yuli ,  LANDRY, Donald ,  YADAV, Vijay

IPC分类号： A61K38/16 ,  A01N43/66

CPC分类号： A61K31/505 ,  A61K31/357 ,  A61K31/513 ,  A61K45/06 ,  G01N33/942 ,  G01N2800/108 ,  G01N2800/50 ,  A61K2300/00

摘要： The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPHl inhibitors or serotonin receptor antagonists.