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公开(公告)号：EP3510026A1
公开(公告)日：2019-07-17
申请号：EP17768322.4
申请日：2017-09-05
发明人： GAUL, Micheal , XU, Guozhang , YANG, Shyh-Ming , LU, Tianbao , ZHANG, Rui , SONG, Fengbin
IPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D401/06 , C07D409/04 , A61K31/416 , A61P3/10
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：EP1893598A1
公开(公告)日：2008-03-05
申请号：EP06772652.1
申请日：2006-06-07
发明人： BAINDUR, Nand , GAUL, Michael David , KREUTTER, Kevin, Douglas , XU, Guozhang , TUMAN, Robert, W. , JOHNSON, Dana, L. , BAUMANN, Christian, Andrew , KIM, Alexander, J.
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/517 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: wherein R1, R2, R3, B, Z, G, Q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c kit and/or TrkB . The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
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