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公开(公告)号：EP1899319A2
公开(公告)日：2008-03-19
申请号：EP06772478.1
申请日：2006-06-07
发明人： BAINDUR, Nand , GAUL, Michael, David , KREUTTER, Kevin, Douglas , BAUMANN, Christian, Andrew , XU, Guozhang , KIM, Alexander, J. , ZHAO, Bao-Ping
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04
摘要： The invention is directed to aminoquinoline and aminoquinazoline compounds of Formula I: where R1, R2, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
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公开(公告)号：EP3510028B1
公开(公告)日：2020-08-05
申请号：EP17771923.4
申请日：2017-09-05
发明人： GAUL, Micheal , XU, Guozhang , YANG, Shyh-ming , LU, Tianbao , ZHANG, Rui , SONG, Fengbin
IPC分类号： C07D405/14 , C07D231/56 , C07D401/06 , C07D403/04 , C07D409/04 , A61K31/416 , A61P3/10
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3.发明公开
公开(公告)号：EP4185588A1
公开(公告)日：2023-05-31
申请号：EP21758491.1
申请日：2021-07-22
发明人： MACIELAG, Mark J. , XU, Guozhang , GAUL, Micheal D. , THIEU, Tho V. , ZHANG, Jing , WALL, Mark , GAO, Ling Hua , ZHU, Bin , LU, Tianbao , GUO, Boying , LIU, Zhijie , NARGUND, Ravi
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02 , A61P29/00
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公开(公告)号：EP3510022B1
公开(公告)日：2020-08-05
申请号：EP17768906.4
申请日：2017-09-05
发明人： GAUL, Micheal , XU, Guozhang , ZHAO, Bao-ping
IPC分类号： C07D401/06 , C07D409/04 , C07D209/08 , A61K31/404 , A61P3/10
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公开(公告)号：EP3510028A1
公开(公告)日：2019-07-17
申请号：EP17771923.4
申请日：2017-09-05
发明人： GAUL, Micheal , XU, Guozhang , YANG, Shyh-ming , LU, Tianbao , ZHANG, Rui , SONG, Fengbin
IPC分类号： C07D405/14 , C07D231/56 , C07D401/06 , C07D403/04 , C07D409/04 , A61K31/416 , A61P3/10
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：EP3510026B1
公开(公告)日：2020-08-12
申请号：EP17768322.4
申请日：2017-09-05
发明人： GAUL, Micheal , XU, Guozhang , YANG, Shyh-Ming , LU, Tianbao , ZHANG, Rui , SONG, Fengbin
IPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D401/06 , C07D409/04 , A61K31/416 , A61P3/10
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公开(公告)号：EP2968258B1
公开(公告)日：2020-02-12
申请号：EP14717254.8
申请日：2014-03-07
发明人： GAUL, Micheal , KUO, Gee-Hong , XU, Guozhang , ZHAO, Bao-Ping
IPC分类号： C07D407/10 , C07D405/10 , C07D409/10 , C07D409/14 , C07D417/10 , A61K31/351 , A61P3/10
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公开(公告)号：EP3510022A1
公开(公告)日：2019-07-17
申请号：EP17768906.4
申请日：2017-09-05
发明人： GAUL, Micheal , XU, Guozhang , ZHAO, Bao-ping
IPC分类号： C07D401/06 , C07D409/04 , C07D209/08 , A61K31/404 , A61P3/10
摘要： The present invention is directed to indole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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9.发明公开INTERMEDIATES USEFUL IN THE SYNTHESIS OF ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS AND RELATED METHODS OF SYNTHESIS 审中-公开ALKYLCHINOLIN-和合成的合适ALKYLCHINAZOLINKINASEMODULATOREN产品及任何相关合成过程之间
公开(公告)号：EP1891040A1
公开(公告)日：2008-02-27
申请号：EP06760725.9
申请日：2006-06-07
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D405/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: wherein R1, R2, R99, and X are as defined herein, the use of such compounds in the sysnthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
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公开(公告)号：EP4185587A1
公开(公告)日：2023-05-31
申请号：EP21754730.6
申请日：2021-07-21
发明人： XU, Guozhang , MACIELAG, Mark J. , LIU, Zhijie , THIEU, Tho V. , NARGUND, Ravi
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02 , A61P29/00
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