公开(公告)号：EP1282646A2

公开(公告)日：2003-02-12

申请号：EP01935275.6

申请日：2001-05-08

申请人： MEDAREX, INC.

发明人： DEO, Yashwant, M. ,  KELER, Tibor

IPC分类号： C07K16/28 ,  C12N5/20 ,  A01K67/027 ,  C07K16/46 ,  A61K39/395 ,  A61K47/48 ,  G01N33/569 ,  G01N33/577 ,  C12N15/63 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： A61K39/0011 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/515 ,  A61K2039/6056 ,  C07K14/705 ,  C07K16/28 ,  C07K16/46 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2319/00 ,  G01N33/564

摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal,
e.g. , a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1173485A1

公开(公告)日：2002-01-23

申请号：EP00944598.2

申请日：2000-05-03

申请人： MEDAREX, INC.

发明人： KELER, Tibor ,  DEO, Yashwant, M.

IPC分类号： C07K16/12 ,  C07K16/28 ,  C07K16/46 ,  C12N5/20 ,  A61K39/40 ,  G01N33/569 ,  A61P31/04 ,  A01K67/027

CPC分类号： C07K16/1271 ,  A01K2217/05 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/77 ,  G01N2333/31

摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to one or more S. aureus strains, including methicillin resistant S. aureus strains, are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP0914346A1

公开(公告)日：1999-05-12

申请号：EP97934094.0

申请日：1997-07-10

申请人： Medarex, Inc.

发明人： DEO, Yashwant, M. ,  GRAZIANO, Robert ,  KELER, Tibor

IPC分类号： C12N15 ,  A61K31 ,  A61K39 ,  A61P31 ,  A61P35 ,  C07K14 ,  C07K16 ,  C07K19 ,  C12P21 ,  G01N33 ,  A61K38

CPC分类号： C07K14/33 ,  A61K38/00 ,  C07K16/14 ,  C07K16/283 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77

摘要： Multispecific compounds comprising at least one binding determinant which binds to the Fcx-receptor on an effector cell. The other binding determinant(s) binds(s) to one or more antigens on a target cell, e.g., the Neu/Her-2 proto-oncogene product or the epidermal growth factor receptor on cancer cells, or to Candida antigens on infected cells. Examples are biospecific and trispecific antibodies. Therapeutic use of said multispecific compounds for treatment of cancers or pathogen infections.