公开(公告)号：EP1633785B1

公开(公告)日：2012-11-28

申请号：EP04809410.6

申请日：2004-05-21

申请人： Medarex, Inc.

发明人： KELER, Tibor ,  BLANSET, Diann ,  VITALE, Laura, A. ,  LOWY, Israel ,  SRINIVASAN, Mohan

IPC分类号： C07K16/12 ,  A61K39/395 ,  G01N33/53 ,  C12N15/20 ,  C12N15/13 ,  A61K47/48 ,  A61P31/04

CPC分类号： C07K16/1278 ,  A61K47/6835 ,  A61K51/1009 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP0914346B1

公开(公告)日：2006-03-01

申请号：EP97934094.0

申请日：1997-07-10

申请人： MEDAREX, INC.

发明人： DEO, Yashwant, M. ,  GRAZIANO, Robert ,  KELER, Tibor

IPC分类号： C07K16/46 ,  A61K39/395 ,  A61K38/19 ,  A61K35/14 ,  G01N33/68 ,  C07K16/28

CPC分类号： C07K14/33 ,  A61K38/00 ,  C07K16/14 ,  C07K16/283 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77

摘要： Multispecific compounds comprising at least one binding determinant which binds to the Fcx-receptor on an effector cell. The other binding determinant(s) binds(s) to one or more antigens on a target cell, e.g., the Neu/Her-2 proto-oncogene product or the epidermal growth factor receptor on cancer cells, or to Candida antigens on infected cells. Examples are biospecific and trispecific antibodies. Therapeutic use of said multispecific compounds for treatment of cancers or pathogen infections.

公开(公告)号：EP1471938A2

公开(公告)日：2004-11-03

申请号：EP03703723.1

申请日：2003-01-07

申请人： Medarex, Inc.

发明人： KELER, Tibor ,  GRAZIANO, Robert ,  TREML, John ,  DEO, Yashwant, M.

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  C07K16/30

CPC分类号： C07K16/2878 ,  A01K2217/075 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/73 ,  Y02A50/412

摘要： Isolated human monoclonal antibodies which bind to CD30 (e.g., human CD30) are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1212366A2

公开(公告)日：2002-06-12

申请号：EP00948934.5

申请日：2000-07-25

申请人： Medarex, Inc.

发明人： DEO, Yashwant, M. ,  GOLDSTEIN, Joel ,  GRAZIANO, Robert ,  KELER, Tibor

IPC分类号： C07K19/00 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/283 ,  A61K38/1808 ,  A61K2039/505 ,  C07K14/485 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2319/00

摘要： Multispecific molecules which induce effector cell-mediated killing of target cells are disclosed. The molecules are 'multispecific' because they bind to multiple (two or more), distinct targets, one of which is an Fc receptor on the surface of an immune cell. Multispecific molecules of the invention include molecules comprised of at least one portion which binds to an Fc receptor, such as an Fcη receptor (e.g., FcηRI) or an Fcα receptor, and at least one other portion which binds to a different target, such as an antigen on a tumor cell or a pathogen. Multispecific molecules of the invention also include antigen 'multimer complexes' comprised of multiple (i.e., two or more) portions which bind to a molecule on an antigen presenting cell (APC), such as an Fc receptor, linked to one or more antigens. These multimer complexes target antigens, such as self-antigens, to APCs to induce and/or enhance internalization (endocytosis), processing and/or presentation of the antigen by the APC. Therefore, these molecules can be used to induce or enhance an immune response either in vivo or in vitro against a normally non-immunogenic protein, such as a self-antigen. In a particular embodiment, at least one portion of the multispecific molecules comprises a humanized or human antibody or antibody fragment (e.g., ScFv or Fab') which binds to an Fc receptor or a receptor on a target cell (e.g., EGF-R or HER2).

公开(公告)号：EP1212366B1

公开(公告)日：2007-09-12

申请号：EP00948934.5

申请日：2000-07-25

申请人： MEDAREX, INC.

发明人： DEO, Yashwant, M. ,  GOLDSTEIN, Joel ,  GRAZIANO, Robert ,  KELER, Tibor

IPC分类号： C07K19/00 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K14/485

CPC分类号： C07K16/283 ,  A61K38/1808 ,  A61K2039/505 ,  C07K14/485 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2319/00

摘要： Multispecific molecules which induce effector cell-mediated killing of target cells are disclosed. The molecules are 'multispecific' because they bind to multiple (two or more), distinct targets, one of which is an Fc receptor on the surface of an immune cell. Multispecific molecules of the invention include molecules comprised of at least one portion which binds to an Fc receptor, such as an Fcη receptor (e.g., FcηRI) or an Fcα receptor, and at least one other portion which binds to a different target, such as an antigen on a tumor cell or a pathogen. Multispecific molecules of the invention also include antigen 'multimer complexes' comprised of multiple (i.e., two or more) portions which bind to a molecule on an antigen presenting cell (APC), such as an Fc receptor, linked to one or more antigens. These multimer complexes target antigens, such as self-antigens, to APCs to induce and/or enhance internalization (endocytosis), processing and/or presentation of the antigen by the APC. Therefore, these molecules can be used to induce or enhance an immune response either in vivo or in vitro against a normally non-immunogenic protein, such as a self-antigen. In a particular embodiment, at least one portion of the multispecific molecules comprises a humanized or human antibody or antibody fragment (e.g., ScFv or Fab') which binds to an Fc receptor or a receptor on a target cell (e.g., EGF-R or HER2).

公开(公告)号：EP1633785A2

公开(公告)日：2006-03-15

申请号：EP04809410.6

申请日：2004-05-21

申请人： MEDAREX, INC.

发明人： KELER, Tibor ,  BLANSET, Diann ,  VITALE, Laura, A. ,  LOWY, Israel ,  SRINIVASAN, Mohan

IPC分类号： C07K16/00

CPC分类号： C07K16/1278 ,  A61K47/6835 ,  A61K51/1009 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： Isolated human monoclonal antibodies which bind to Anthrax protective antigen 035 disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. A1so disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1210372A2

公开(公告)日：2002-06-05

申请号：EP00950679.1

申请日：2000-07-25

申请人： MEDAREX, INC.

发明人： KELER, Tibor ,  DEO, Yashwant

IPC分类号： C07K16/00

CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/01 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/283 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00

摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to HER2/neu are disclosed. Also disclosed are bi- and multispecific molecules including human monoclonal antibodies and antigen-binding portions thereof which specifically bind to HER2/neu. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1044263A2

公开(公告)日：2000-10-18

申请号：EP98960647.0

申请日：1998-12-02

申请人： MEDAREX, INC.

发明人： KELER, Tibor ,  GOLDSTEIN, Joel ,  GRAZIANO, Robert ,  DEO, Yashwant, M.

IPC分类号： C12N5/22 ,  C07K16/28 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K2039/5152 ,  A61K2039/5156 ,  C07K14/71 ,  C07K16/283 ,  C07K2317/54 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2319/00

摘要： Cells transformed to express on their surface a component which binds to an Fc receptor of an effector cell are disclosed. Also disclosed are expression vectors used to transform the cells. Once transformed, the cells bind to effector cells via the Fc receptor of the effector cell to stimulate an effector cell mediated immune response.

公开(公告)号：EP1210372B1

公开(公告)日：2008-01-23

申请号：EP00950679.1

申请日：2000-07-25

申请人： MEDAREX, INC.

发明人： KELER, Tibor ,  DEO, Yashwant ,  VITALE, Laura

IPC分类号： C07K16/00

CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/01 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/283 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00

摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to HER2/neu are disclosed. Also disclosed are bi- and multispecific molecules including human monoclonal antibodies and antigen-binding portions thereof which specifically bind to HER2/neu. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1802345A2

公开(公告)日：2007-07-04

申请号：EP05816220.7

申请日：2005-09-30

申请人： MEDAREX, INC.

发明人： KELER, Tibor ,  STRANDMANN, Elke, Pogge, von ,  ENGERT, Andreas ,  BORCHMANN, Peter ,  BÖELL, Boris

IPC分类号： A61K39/395

CPC分类号： C07K16/2878 ,  A61K39/39541 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  A61K2300/00

摘要： Methods for treating lymphomas characterized by expression of CD30 Using anti-CD30 antibodies and proteasome inhibitors in combination are disclosed.