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公开(公告)号：EP0946165B1
公开(公告)日：2003-04-09
申请号：EP97947280.0
申请日：1997-10-27
申请人： MERCK & CO., INC.
IPC分类号： A61K31/18 , A61K31/19 , A61K31/44 , A61K31/47 , A61K31/195 , A61K31/405 , A61K31/415 , A61K31/425 , A61K31/435 , A61K31/505 , A61P9/10 , A61P19/02 , A61P19/04 , A61P19/10 , A61P35/00
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D471/04
摘要： This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are αvβ3 antagonists, αvβ5 antagonists or dual αvβ3/αvβ5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
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公开(公告)号：EP1100506A1
公开(公告)日：2001-05-23
申请号：EP99935910.2
申请日：1999-07-26
申请人： MERCK & CO., INC.
IPC分类号： A61K31/505 , A61K31/435 , A61K31/415 , C07D401/10 , C07D403/10 , C07D405/12 , C07D409/14 , C07D471/04
CPC分类号： C07D213/73 , A61K45/06 , C07D239/14 , C07D239/42
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3, αvβ5 and/or αvβ6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, and tumor growth and metastasis.
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公开(公告)号：EP1044001A1
公开(公告)日：2000-10-18
申请号：EP98963893.7
申请日：1998-12-14
申请人： MERCK & CO., INC.
IPC分类号： A61K31/495 , A61K31/445 , C07D417/14 , C07D401/14
CPC分类号： C07D471/04 , A61K41/00 , A61K45/06
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αξβ3, αξβ5, and/or αξβ6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
摘要翻译： 本发明涉及化合物及其衍生物，它们的合成及其作为整联蛋白受体拮抗剂的用途。 更具体地说，本发明化合物是整联蛋白受体αξβ3，αξβ5和/或αξβ6的拮抗剂，可用于抑制骨吸收，治疗和预防骨质疏松症，抑制血管再狭窄，糖尿病性视网膜病，黄斑变性，血管生成，动脉粥样硬化 ，炎症，伤口愈合，病毒性疾病，肿瘤生长和转移。
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公开(公告)号：EP0934305A1
公开(公告)日：1999-08-11
申请号：EP97938568.0
申请日：1997-08-25
申请人： MERCK & CO., INC.
发明人： DUGGAN, Mark, E. , HARTMAN, George, D. , HOFFMAN, William, F. , MEISSNER, Robert, S. , PERKINS, James, J. , ASKEW, Ben, C. , COLEMAN, Paul, J. , HUTCHINSON, John, H. , NAYLOR-OLSEN, Adel, M.
IPC分类号： A61K31 , A61P3 , A61P9 , A61P19 , A61P27 , A61P29 , A61P35 , A61P43 , C07D471 , C07D519 , C07K5 , A61K38
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K38/00 , C07K5/0202
摘要： This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are αvβ3 antagonists, αvβ5 antagonists or dual αvβ3/αvβ5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
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公开(公告)号：EP1040111B1
公开(公告)日：2005-06-22
申请号：EP98963915.8
申请日：1998-12-14
申请人： MERCK & CO., INC.
发明人： DUGGAN, Mark, E. , MEISSNER, Robert, S. , HUTCHINSON, John, H. , HALCZENKO, Wasyl , ASKEW, Ben, C. , COLEMAN, Paul, J. , PATANE, Michael, A. , WANG, Jiabing , PERKINS, James J.
IPC分类号： C07D471/04 , C07D401/06 , C07D401/14 , C07D519/00 , A61K31/415 , A61K31/44
CPC分类号： C07D471/04 , A61K31/415 , A61K31/44 , A61K31/66 , A61K45/06 , C07D401/14 , A61K2300/00
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3, αvβ5 and/or αvβ6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.
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公开(公告)号：EP1494675A2
公开(公告)日：2005-01-12
申请号：EP03746593.7
申请日：2003-04-04
申请人： Merck & Co., Inc.
IPC分类号： A61K31/497 , C07D401/14
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公开(公告)号：EP0901373B1
公开(公告)日：2002-11-06
申请号：EP97920270.2
申请日：1997-04-08
申请人： MERCK & CO., INC.
IPC分类号： C07D209/46 , A61K31/40 , C07D403/12 , A61K31/495 , C07D401/12 , A61K31/44
CPC分类号： C07D401/12 , C07D209/46 , C07D403/12
摘要： This invention relates to certain novel isoindolone compounds and derivatives thereof, their synthesis, and their use as αvβ3 receptor antagonists. The αvβ3 receptor antagonist compounds of this invention are useful for inhibiting bone resorption, treating and preventing osteoporosis and cancer, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
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公开(公告)号：EP1252162A1
公开(公告)日：2002-10-30
申请号：EP01942625.3
申请日：2001-01-16
申请人： Merck & Co., Inc.
发明人： DUGGAN, Mark, E. , HALCZENKO, Wasyl , HUTCHINSON, John, H. , LI, Aiwen , MEISSNER, Robert, S. , PERKINS, James, J. , STEELE, Thomas, G. , WANG, Jiabing , PATANE, Michael, A.
IPC分类号： C07D471/04 , C07D401/06 , A61K31/4375 , A61K31/444
CPC分类号： C07D213/73 , A61K45/06 , C07D401/14 , C07D405/14 , C07D471/04 , C07D471/10
摘要： The present invention relates to novel imidazolidinone derivatives thereof, their synthesis, and their use as αν integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.
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公开(公告)号：EP1047425A1
公开(公告)日：2000-11-02
申请号：EP98962096.8
申请日：1998-12-14
申请人： MERCK & CO., INC.
IPC分类号： A61K31/435 , A61K31/40 , C07D207/26 , C07D413/06 , C07D471/04 , C07D401/06
CPC分类号： C07D471/04 , A61K31/66 , A61K45/06 , C07D401/14 , C07D519/00 , A61K2300/00
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the vitronectin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, viral disease, and tumor growth.
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公开(公告)号：EP1007026A1
公开(公告)日：2000-06-14
申请号：EP98903466.5
申请日：1998-01-13
申请人： MERCK & CO., INC.
发明人： DUGGAN, Mark, E.
IPC分类号： A61K31/18 , A61K31/19 , A61K31/44 , A61K31/47 , A61K31/195 , A61K31/405 , A61K31/415 , A61K31/425 , A61K31/435 , C07C63/00 , C07C307/06 , C07C307/08 , C07C307/10 , C07D213/89 , C07D217/08 , C07D233/44 , C07D233/88 , C07D239/08 , C07D239/42 , C07D209/40
CPC分类号： C07D471/04 , A61K31/66 , A61K31/445 , A61K2300/00
摘要： This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are αvβ3 antagonists, αvβ5 antagonists or dual αvβ3/αvβ5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, viral disease, and tumor growth.
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