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公开(公告)号：EP2262537A1
公开(公告)日：2010-12-22
申请号：EP09717479.1
申请日：2009-02-26
发明人： WANG, Xinghe , ZHAO, Gang , VAN, Sang , YU, Lei , FENG, Zhongling
CPC分类号： A61K47/645
摘要： Pharmaceutical compositions comprising a PGGA-PTX conjugate are prepared. The pharmaceutical compositions are used to treat a variety of cancers, such as lung cancer, skin cancer, kidney cancer, liver cancer and spleen cancer.
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公开(公告)号：EP2144631A2
公开(公告)日：2010-01-20
申请号：EP08745311.4
申请日：2008-04-08
发明人： YU, Lei , ZHAO, Gang , VAN, Sang
CPC分类号： A61K49/146 , A61K47/60 , A61K47/62 , A61K47/645 , A61K49/0002 , A61K49/085
摘要： Various biodegradable polyglutamate polymer conjugates that can include recurring units of the general formulae (I) and (II) are described herein. Such polymer conjugates are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
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公开(公告)号：EP1812074A1
公开(公告)日：2007-08-01
申请号：EP05810515.6
申请日：2005-10-17
发明人： MINOMI, Kenjiro , YU, Lei
IPC分类号： A61K47/48
CPC分类号： A61K38/47 , A61K47/183 , A61K47/59 , A61K47/645 , A61K47/6901 , C07K14/005 , C07K2319/10 , C12N15/87 , C12N2740/16322
摘要： Methods and kits for transporting heterologous compounds into cells, particularly mammalian cells, are disclosed. The method involves the pretreatment of the cell with a polycation, cationic polymer and/or cationic peptide before transportation of the heterologous compound into the cell. The methods are particularly applicable to the transport of peptides and proteins.
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14.发明授权CONTROLLABLY DEGRADABLE POLYMERIC BIOMOLECULE OR DRUG CARRIER AND METHOD OF SYNTHESIZING SAID CARRIER 有权可控降解聚合物，生物分子或活动载体和方法合成该行星
公开(公告)号：EP1503802B1
公开(公告)日：2005-12-14
申请号：EP03728863.6
申请日：2003-05-13
发明人： YU, Lei , DU, Fusheng , JI, Shouping , MATSUMOTO, Kenji
CPC分类号： C08G73/02 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/645 , A61K48/0041
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公开(公告)号：EP1601721A1
公开(公告)日：2005-12-07
申请号：EP04714119.7
申请日：2004-02-24
发明人： YU, Lei , VAN, Sang , JI, Shouping , MATSUMOTO, Kenji
CPC分类号： C08G73/0213 , A61K47/59 , C08G65/002
摘要： A polymer comprising recurring units represented by formula (I); wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VZ, where R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of -(CH2)2-, -(CH2)2-O-(CH2)2-, -(CH2)2-O-(CH2)2-O-(CH2)2-, and -(CH2)3-NHC(O)-(CH2)6-C(O)NH-(CH2)3- is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.
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16.发明公开
公开(公告)号：EP1587954A1
公开(公告)日：2005-10-26
申请号：EP03796622.3
申请日：2003-12-04
发明人： YU, Lei , MATSUMOTO, Kenji , JI, Shouping , DU, Fusheng
CPC分类号： C12N15/87 , A61K47/644 , A61K47/645 , A61K48/00
摘要： The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.
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17.发明公开REDUCTION OF ENDOTOXINS FROM POLYANIONIC POLYMER CONJUGATES 审中-公开呕吐内分泌US US EN EN N N N N N N N N N N N N N N N
公开(公告)号：EP2989116A1
公开(公告)日：2016-03-02
申请号：EP13882935.3
申请日：2013-04-26
发明人： TSANG, Kwok, Yin , BAI, Hao , JIN, Yi , YU, Lei
CPC分类号： A61K47/645 , A61K31/337 , A61K47/595 , C08G69/10 , C08G69/46 , C08G69/48
摘要： Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.
摘要翻译： 本文描述的是降低聚阴离子聚合物缀合物的内毒素含量的方法。 特别地，本文描述了可以用于多种药物递送应用的聚阴离子聚合物缀合物中减少内毒素含量的方法。
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公开(公告)号：EP1664144B1
公开(公告)日：2011-04-27
申请号：EP04779365.8
申请日：2004-07-28
发明人： VAN, Sang , VIROONCHATAPAN, Nitnara , JI, Shouping , YU, Lei
CPC分类号： C08G4/00 , C07C229/22 , C08G73/028
摘要： Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II): wherein A comprises at least one acetal group; B is selected from the group consisting of -CH-, -CH(CH3)-, CH2CH-, -CH2C(CH3)-, -CH(CH3)CH-, and -CHCH(CH3)CH(CH3)-; Z is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VU; V is a linker group; U is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, hexadecaamine dendrimer, enhancer, and targeting receptor; R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl; D is a linkage selected from the group consisting of carboxylic amide, carboxylic ester, urea, and urethane; and G is selected from the group consisting of C4 to C20 alkyl, C6-C10 aryl, and -(OCH2CH2)n-, where n is in the range of 1 to about 250, are useful in nucleic acid delivery applications. In preferred embodiments, complexes formed between polyacetals comprising recurring units of the formulae (I) or (II) and polynucleotides are useful as transfection reagents.
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公开(公告)号：EP1812074B1
公开(公告)日：2010-12-29
申请号：EP05810515.6
申请日：2005-10-17
发明人： MINOMI, Kenjiro , YU, Lei
CPC分类号： A61K38/47 , A61K47/183 , A61K47/59 , A61K47/645 , A61K47/6901 , C07K14/005 , C07K2319/10 , C12N15/87 , C12N2740/16322
摘要： Methods and kits for transporting heterologous compounds into cells, particularly mammalian cells, are disclosed. The method involves the pretreatment of the cell with a polycation, cationic polymer and/or cationic peptide before transportation of the heterologous compound into the cell. The methods are particularly applicable to the transport of peptides and proteins.
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公开(公告)号：EP2207570A2
公开(公告)日：2010-07-21
申请号：EP08830537.0
申请日：2008-09-12
发明人： YU, Lei , LIU, Jian , ZHAO, Gang , MA, Nianchun , VAN, Sang
IPC分类号： A61K47/48 , A61K31/337
CPC分类号： A61K31/337 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K47/6455
摘要： Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
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