公开(公告)号：EP1687305B1

公开(公告)日：2008-07-09

申请号：EP04798017.2

申请日：2004-11-19

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： CAPRARO, Hans-Georg ,  CARAVATTI, Giorgio ,  FURET, Pascal ,  GARCIA-ECHEVERRIA, Carlos ,  IMBACH, Patricia ,  STAUFFER, Frédéric

IPC分类号： C07D471/04 ,  A61K31/435 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The invention relates to imidazoquinolines of formula (I) for use in the treatment of protein kinase dependent diseases; pharmaceutical preparations comprinsing an imidazoquinoline, especially for the treatment of a pretein kinase dependent disease; novel imidazoquinolines; and a process for the preparation of the novel imidazoquinilines.

公开(公告)号：EP1173413B1

公开(公告)日：2004-06-30

申请号：EP00927038.0

申请日：2000-04-25

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： FRANCE, Dennis ,  FÜRST, Peter ,  ZIMMERMANN, Johann ,  GARCIA-ECHEVERRIA, Carlos ,  SCHOLZ, Dieter ,  FURET, Pascal ,  IMBACH, Patricia

IPC分类号： C07C271/22 ,  A61P43/00 ,  A61K31/325

CPC分类号： C07C271/22 ,  Y02P20/55

公开(公告)号：EP1399468A1

公开(公告)日：2004-03-24

申请号：EP02743128.7

申请日：2002-05-29

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： FURET, Pascal ,  GUAGNANO, Vito ,  IMBACH, Patricia ,  LANG, Marc

IPC分类号： C07K5/06 ,  A61K31/69

CPC分类号： C07K5/06191 ,  A61K38/00

摘要： The present invention relates to compounds of formula (I) their synthesis and pharmaceutical compositions thereof for the therapeutic treatment of a proliferative diseases in warm-blooded animals, including humans.

公开(公告)号：EP2004652A1

公开(公告)日：2008-12-24

申请号：EP07723893.9

申请日：2007-04-02

申请人： NOVARTIS AG ,  NOVARTIS-PHARMA GMBH

发明人： MASUYA, Keiichi ,  VAUPEL, Andrea ,  IMBACH, Patricia ,  FURET, Pascal

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： The invention relates to 3-unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidine compounds, their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase, especially tie-2 kinase, activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds.

公开(公告)号：EP1399468B1

公开(公告)日：2006-02-15

申请号：EP02743128.7

申请日：2002-05-29

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： FURET, Pascal ,  GUAGNANO, Vito ,  IMBACH, Patricia ,  LANG, Marc

IPC分类号： C07K5/06 ,  A61K31/69

CPC分类号： C07K5/06191 ,  A61K38/00

摘要： The present invention relates to compounds of formula (I) their synthesis and pharmaceutical compositions thereof for the therapeutic treatment of a proliferative diseases in warm-blooded animals, including humans.

公开(公告)号：EP1153024B1

公开(公告)日：2004-04-28

申请号：EP00916840.2

申请日：2000-02-16

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： IMBACH, Patricia ,  CAPRARO, Hans-Georg ,  ZIMMERMANN, Jürg ,  CARAVATTI, Giorgio ,  FURET, Pascal ,  BRILL, Wolfgang, Karl-Diether

IPC分类号： C07D473/16 ,  C07D473/40 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07D473/16 ,  C07D473/40

摘要： 2-Amino-6-anilino-purine derivatives of formula (I) in which R1 is -S(O)k-NR6R7 or-N(aryl lower alkyl) carbamoyl or -NH-S(O)i-R8 or -NH-C(O)-R9; 9 is 1-5; These compounds inhibit p34cdc2/cyclin Bcdc13 kinase and protein tyrosine kinase pp60c-src and can be used for treatment of hyperproliferative diseases, for example tumour diseases, and diseases which respond to inhibition of the activity of protein tyrosine kinase pp60c-src, in particular osteoporosis.

公开(公告)号：EP0874846B1

公开(公告)日：2003-04-02

申请号：EP96934774.9

申请日：1996-10-22

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ZIMMERMANN, Jürg ,  CAPRARO, Hans-Georg ,  IMBACH, Patricia ,  FURET, Pascal

IPC分类号： C07D473/16 ,  C07D473/00 ,  C07D473/40

CPC分类号： C07D473/16

公开(公告)号：EP2438063A1

公开(公告)日：2012-04-11

申请号：EP10720790.4

申请日：2010-06-02

申请人： Novartis AG

发明人： FURET, Pascal ,  IMBACH, Patricia ,  MAH, Robert ,  STAUFFER, Frédéric

IPC分类号： C07D471/04 ,  C07D471/14 ,  A61K31/4353 ,  A61K31/4745 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D471/14

摘要： The invention relates to the use of 1
H -imidazo[4,5-
c ]quinolinone compounds and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1
H -imidazo[4,5-
c ]quinolinone compounds for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1
H -imidazo[4,5-
c ]quinolinone compounds to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1
H -imidazo[4,5-
c ]quinolinone compounds, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1
H -imidazo[4,5-
c ]quinolinone compounds; and a process for the preparation of the novel 1
H -imidazo[4,5-
c ]quinolinone compounds.

公开(公告)号：EP2155753A1

公开(公告)日：2010-02-24

申请号：EP08750154.0

申请日：2008-05-07

申请人： Novartis AG

发明人： CAPRARO, Hans-Georg ,  IMBACH, Patricia ,  CARAVATTI, Giorgio ,  FURET, Pascal

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D487/04

摘要： The invention relates to novel compounds of formula (I), as well as other invention embodiments related to these compounds. The compounds are e.g. useful in the treatment of the animal or human body in view of their ability to inhibit protein kinases such as especially PI3 kinase.

公开(公告)号：EP1910368A1

公开(公告)日：2008-04-16

申请号：EP06762704.2

申请日：2006-07-19

申请人： Novartis AG

发明人： IMBACH, Patricia ,  FURET, Pascal ,  MARTINY-BARON, Georg

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The invention relates to pyrazolo[1,5a]pyrimidin-7-yl amine derivatives of formula (I) and salts thereof, their use in the treatment of protein kinase dependent diseases.