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    PHARMACOLOGICALLY ACTIVE PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
    3.
    发明授权
    PHARMACOLOGICALLY ACTIVE PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF 失效
    药理活性的嘧啶衍生物和方法及其

    公开(公告)号：EP0672042B1

    公开(公告)日：2006-05-03

    申请号：EP94928384.0

    申请日：1994-09-21

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： ZIMMERMANN, Jürg

    IPC分类号： C07D401/04 ,  C07D239/42

    CPC分类号： C07D239/42 ,  C07D401/04

    摘要： Described are N-phenyl-2-pyrimidineamine derivatives of formula (I) wherein R1 is a substituted cyclic radical, the cyclic radical being bonded to a ring carbon atom in each case and being selected from phenyl, pyridyl, pyrazinyl, thiazolyl, pyrimidinyl, pyridazinyl and imidazolyl, and the substituents of the above-mentioned cyclic radical being selected from one or more of the groups halogen, cyano, carbamoyl, -C(=O)-OR3, -C(=O)-R4, -SO2-N(R5)-R¿6, -N(R7)-R8, -OR9 and fluorine-substituted lower alkyl, wherein R3, R4, R5, R6, R7, R8 and R9 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino; and R2 is selected from halogen, cyano, carbamoyl, -C(=O)-OR10, -C(=O)-R11, -SO2-N(R12)-R13, -N(R14)-R15, -OR16 and fluorine-substituted lower alkyl, wherein R10, R11, R12, R13, R14, R15 and R16 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino. Those compounds can be used, for example, in the treatment of tumour diseases.