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11.发明授权IN VITRO ASSESSMENT OF CARDIOVASCULAR EVENTS BY ASSAY FOR NEO-EPITOPES OF TITIN PROTEIN 有权体外评估根据测试心血管事件的新表位的肌联蛋白蛋白质
公开(公告)号：EP2731960B1
公开(公告)日：2016-11-16
申请号：EP12731501.8
申请日：2012-07-06
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18 , C07K2317/34 , G01N33/566 , G01N33/6893 , G01N2333/4712 , G01N2800/32
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公开(公告)号：EP2135079A2
公开(公告)日：2009-12-23
申请号：EP08749558.6
申请日：2008-04-14
IPC分类号： G01N33/50
CPC分类号： G01N33/5044 , G01N33/5041 , G01N2333/726
摘要： A method for screening for modulators of the secretion by an osteoclast of a wnt or a wnt signal enhancer comprises exposing osteoclasts in culture to a compound to be screened, exposing a wnt sensitive detection system to conditioned medium from said osteoclast culture, and determining whether a wnt signal is present in said medium by assaying for wnt mediated activation of bone formation by osteoblasts or by wnt mediated activation of LRP5 and or LPR6 signalling in a cell by detection of β catenin or detection of translocation of dishevelled, axin, or Fratl to the cell membrane of said cell.
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公开(公告)号：EP3729092A1
公开(公告)日：2020-10-28
申请号：EP18833201.9
申请日：2018-12-19
IPC分类号： G01N33/564 , C07K16/00 , G01N33/574
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公开(公告)号：EP3094979A1
公开(公告)日：2016-11-23
申请号：EP15701300.4
申请日：2015-01-08
摘要： Provided is a method of bioassay for the quantification of peptide fragments elevated in lung diseases such as COPD, SCC, or IPF. The peptide fragments comprise a neo-epitope formed at a cleavage site by cleavage in vivo of elastin by a proteinase. In the method a sample is contacted with an antibody having specific binding affinity for the neo-epitope amino acid sequence and determining the level of binding is determined where the antibody binds one of the following terminal sequences: . . . FGPGVV, . . . VPGLGV or IKAPKL . . . . Also provided are antibodies and immunoassay kits for use in such methods.
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公开(公告)号：EP2715360A1
公开(公告)日：2014-04-09
申请号：EP12723653.7
申请日：2012-05-23
IPC分类号： G01N33/564
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/564 , G01N33/6842 , G01N2333/78 , G01N2800/102
摘要： An assay for citrullinated fragments of SOCS-2, Alpha 1 anti tyrpsin, versican, biglycan, laminin, or other protein having a terminal antibody binding site comprising citrulline in a blood derived sample shows diagnostic relevance in relation to rheumatoid arthritis or fibrotic disease.
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公开(公告)号：EP2707495A1
公开(公告)日：2014-03-19
申请号：EP12720854.4
申请日：2012-05-04
CPC分类号： G01N33/6893 , C07K14/4725 , C07K16/18 , C07K2317/34 , C12Q1/37 , G01N33/6878 , G01N2800/32 , G01N2800/323
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of mimecan, a protein of an atherosclerotic plaque, by a proteinase is provided. In the method a sample, such as urine or serum, is contacted with an antibody reactive with the neo-epitope and the level of binding of the antibody to peptide fragments in the sample is determined. The assay is predictive of risk of cardiovascular disease events.
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公开(公告)号：EP3658917A1
公开(公告)日：2020-06-03
申请号：EP18755143.7
申请日：2018-07-27
IPC分类号： G01N33/68 , C07K16/18 , G01N33/564
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公开(公告)号：EP2729578B1
公开(公告)日：2020-03-11
申请号：EP12733674.1
申请日：2012-07-04
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