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11.发明公开NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS 审中-公开烟酸衍生物AS代谢型谷氨酸受体调节剂
公开(公告)号：EP1966144A1
公开(公告)日：2008-09-10
申请号：EP06829702.7
申请日：2006-12-18
申请人： Novartis AG
发明人： GLATTHAR, Ralf , ORAIN, David , SPANKA, Carsten
IPC分类号： C07D213/82 , C07D237/24 , C07D239/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , A61K31/4427 , A61K31/4545 , A61K31/465 , A61K31/4725
CPC分类号： C07D213/82 , C07D239/42 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention relates to novel nicotinic acid derivatives, of formula (I), wherein the substituents are defined in the specification, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
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12.发明授权
公开(公告)号：EP1670803B1
公开(公告)日：2008-03-12
申请号：EP04765790.3
申请日：2004-10-04
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D487/10
CPC分类号： C07D487/10
摘要： The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4-4]non-7-yl)-propionam ides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
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公开(公告)号：EP1877365B1
公开(公告)日：2010-11-10
申请号：EP06724539.9
申请日：2006-04-24
申请人： Novartis AG
IPC分类号： C07C233/74 , C07C233/23 , C07D307/68 , C07D233/90 , C07D249/10 , A61K31/166 , A61K31/165 , A61K31/341 , A61K31/4178 , A61P25/00
CPC分类号： C07C235/54 , C07C233/22 , C07C233/23 , C07C233/74 , C07C235/14 , C07C235/36 , C07C235/78 , C07C237/38 , C07C317/44 , C07D233/90 , C07D249/08 , C07D249/10 , C07D307/68
摘要： The invention provides compounds of formula (I) wherein R1 represents hydrogen or alkyl; R2 represents an unsubstituted or substituted heterocycle or R2 represents an unsubstituted or substituted aryl; R3 represents alkyl or halogen; X represents a single bond or an alkandiyl-group, optionally interrupted by one ore more oxygen atoms or carbonyl groups or carbonyloxy groups in free base or acid addition salt form, processes for their preparation and their use as pharmaceuticals.
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公开(公告)号：EP1877364B1
公开(公告)日：2009-04-08
申请号：EP06724538.1
申请日：2006-04-24
申请人： NOVARTIS AG , Novartis Pharma GmbH
IPC分类号： C07C211/52 , C07D277/42 , C07D231/38 , C07D213/74 , C07D241/42 , C07D241/44 , C07D215/40 , C07D487/04 , C07D231/56 , C07D285/14 , C07D405/04 , C07D239/12 , C07D241/20 , C07D233/54 , C07D235/06
CPC分类号： C07C215/44 , C07C49/747 , C07C2601/14 , C07D213/74 , C07D215/40 , C07D231/38 , C07D231/56 , C07D233/64 , C07D235/06 , C07D239/12 , C07D241/20 , C07D241/42 , C07D241/44 , C07D249/08 , C07D277/42 , C07D285/14 , C07D405/04 , C07D487/04
摘要： The invention provides compounds of formula (I) wherein the substituents are as defined in the specification, to processes for their preparation and corresponding intermediates, and their use as modulators of the mglu5 receptor.
摘要翻译： 本发明提供了其中取代基如说明书中所定义的式（I）化合物，它们的制备方法和相应的中间体，以及它们作为mglu5受体的调节剂的用途。
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公开(公告)号：EP1877367A1
公开(公告)日：2008-01-16
申请号：EP06724540.7
申请日：2006-04-24
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
IPC分类号： C07C271/24 , C07D307/68 , C07D307/85 , C07D213/81 , C07D213/82 , C07D231/38 , C07D307/32 , C07D295/08 , C07D211/58 , C07C309/14 , C07D233/54 , A61P1/00 , A61P13/00 , A61P25/00 , A61K31/325
CPC分类号： C07C215/44 , C07C217/84 , C07C271/24 , C07C2601/14 , C07D211/58 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/64 , C07D295/096 , C07D307/33 , C07D307/68 , C07D307/85 , C07D453/02
摘要： The invention provides compounds of formula (I), wherein the substituents are as defined in the specification, to processes for their preparation and their use as pharmaceuticals.
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16.发明公开
公开(公告)号：EP1670803A1
公开(公告)日：2006-06-21
申请号：EP04765790.3
申请日：2004-10-04
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D487/10
CPC分类号： C07D487/10
摘要： The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4-4]non-7-yl)-propionam ides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
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