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11.发明公开
公开(公告)号：EP1463504A1
公开(公告)日：2004-10-06
申请号：EP02790487.9
申请日：2002-12-12
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： A61K31/427 , A61P35/00 , A61K38/16 , A61K38/21 , A61K31/513 , A61K31/704 , A61K31/675 , A61K31/7008
CPC分类号： A61K45/06 , A61K31/427 , A61K31/513 , A61K31/675 , A61K31/7008 , A61K31/704 , A61K38/16 , A61K38/21 , A61K2300/00
摘要： Use of a compound of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, R' is methyl, methoxy, ethoxy, amino, methylamino, dimethylamino, aminomethyl or methylthio, and Z is O or a bond, or a pharmaceutically acceptable salt thereof, alone or in combination with at least one compound selected from the group consisting of somatostatin or a synthetic derivative thereof, interferon- 5-fluorouracil, doxorubicin, cyclophosphamide, streptozotocin and a standard anti-diarrheal, for the preparation of a medicament for the treatment of carcinoid syndrome or at least one neuroendocrine tumor; a method of treating a warm-blooded animal, having carcinoid syndrome and/or at least one neuroendocrine tumor; a combination comprising a compound formula I as defined above and at least one compound selected from the group provided above; and to a commercial package comprising said combination.
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公开(公告)号：EP1412029A2
公开(公告)日：2004-04-28
申请号：EP02764726.2
申请日：2002-07-18
申请人： Novartis AG , Novartis Pharma GmbH
发明人： CHEN, TianLing , GREELEY, Diane , ROTHERMEL, John, David , WARTMANN, Markus , WOOD, Jeanette, Marjorie
IPC分类号： A61P35/00 , A61K31/427 , A61K31/282 , A61K33/24 , A61K31/4439 , A61K31/663
CPC分类号： A61K31/663 , A61K31/427 , A61K31/502 , A61K31/555 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula (I), wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.
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13.发明公开COMBINATIONS COMPRISING AN ANTIDIARRHEAL AGENT AND AN EPOTHILONE OR AN EPOTHILONE DERIVATIVE 有权COMBINING，ON止泻AND OR埃博埃坡霉素衍生物含
公开(公告)号：EP1372650A2
公开(公告)日：2004-01-02
申请号：EP02719992.6
申请日：2002-03-18
IPC分类号： A61K31/445 , A61K33/24 , A61K33/06 , A61K38/31 , A61K31/427 , A61P1/12 , A61P35/00
CPC分类号： A61K45/06 , Y10S514/867 , Y10S514/974
摘要： Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
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14.发明授权COMBINATIONS COMPRISING AN ANTIDIARRHEAL AGENT AND AN EPOTHILONE OR AN EPOTHILONE DERIVATIVE 有权COMBINING，ON止泻AND OR埃博埃坡霉素衍生物含
公开(公告)号：EP1372650B1
公开(公告)日：2008-11-19
申请号：EP02719992.6
申请日：2002-03-18
IPC分类号： A61K31/445 , A61K33/24 , A61K33/06 , A61K38/31 , A61K31/427 , A61P1/12 , A61P35/00
CPC分类号： A61K45/06 , Y10S514/867 , Y10S514/974
摘要： Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
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