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14 条记录 (耗时 0.01 秒)

    COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF
    1.
    发明授权
    COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF 有权
    埃博霉素含组合及其药物用途

    公开(公告)号：EP1515750B1

    公开(公告)日：2010-08-11

    申请号：EP03757040.5

    申请日：2003-06-06

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： HOHNEKER, John, Arthur ,  MILLER, Julie, Ann ,  ROTHERMEL, John, David ,  WARTMANN, Markus

    IPC分类号： A61K45/06 ,  A61K31/426 ,  A61K31/427 ,  A61P35/00

    CPC分类号： C07K16/3015 ,  A61K31/426 ,  A61K31/427 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07D417/06 ,  A61K2300/00

    摘要： The invention relates to a pharmaceutical combination which comprises (a) a HER-1 or a HER-2 antibody or (b) at least one antineoplastic agent selected from the group consisting of aromatase inhibitors, antiestrogens, topoisomerase I inhibitors, topoisomerase II inhibitors, microtubule active agents, protein kinase C inhibitors, anti-angiogenic compounds, gonadorelin agonists, anti-androgens, histone deacetylase inhibitors and S-adenosyl-methionine decarboxylase inhibitors; and (c) an epothilone derivative of formula (I), and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular, for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.

    EPOTHILONE DERIVATIVE FOR THE TREATMENT OF HEPATOMA AND OTHER CANCER DISEASES
    4.
    发明公开
    EPOTHILONE DERIVATIVE FOR THE TREATMENT OF HEPATOMA AND OTHER CANCER DISEASES 有权
    埃博霉素用于治疗肝癌等多种癌症

    公开(公告)号：EP1503756A1

    公开(公告)日：2005-02-09

    申请号：EP03725129.5

    申请日：2003-04-30

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： ROTHERMEL, John, David

    IPC分类号： A61K31/425 ,  A61P35/00

    CPC分类号： A61K45/06 ,  A61K31/425 ,  A61K31/427 ,  A61K41/00 ,  A61K2300/00

    摘要： The present invention relates to a method of treating a warm-blooded animal, especially a human, having a cancer disease selected from hepatoma; primary fallopian tube cancer; primary peritoneal cancer; breast cancer progressing after treatment with hormonal agents or radiotherapy; renal cell carcinoma progressing after treatment with a cytokine, radiotherapy and/or nephrectomy,; melanoma progressing after radiotherapy; prostate cancer progressing after orchiectomy, ovarian cancer progressing after treatment with a platinum compound or radiotherapy; and colorectal cancer progressing after radiotherapy and/or treatment with oxaliplatin or irinotecan; and metastasis thereof comprising administering to said animal a therapeutically effective amount of an epothilone derivative of formula (I).

    EPOTHILONE DERIVATIVE FOR THE TREATMENT OF HEPATOMA AND OTHER CANCER DISEASES
    5.
    发明授权
    EPOTHILONE DERIVATIVE FOR THE TREATMENT OF HEPATOMA AND OTHER CANCER DISEASES 有权
    埃博霉素用于治疗肝癌等多种癌症

    公开(公告)号：EP1503756B1

    公开(公告)日：2009-08-12

    申请号：EP03725129.5

    申请日：2003-04-30

    申请人： NOVARTIS AG ,  Novartis Pharma GmbH

    发明人： ROTHERMEL, John, David

    IPC分类号： A61K31/425 ,  A61P35/00

    CPC分类号： A61K45/06 ,  A61K31/425 ,  A61K31/427 ,  A61K41/00 ,  A61K2300/00

    摘要： The present invention relates to a method of treating a warm-blooded animal, especially a human, having a cancer disease selected from hepatoma; primary fallopian tube cancer; primary peritoneal cancer; breast cancer progressing after treatment with hormonal agents or radiotherapy; renal cell carcinoma progressing after treatment with a cytokine, radiotherapy and/or nephrectomy,; melanoma progressing after radiotherapy; prostate cancer progressing after orchiectomy, ovarian cancer progressing after treatment with a platinum compound or radiotherapy; and colorectal cancer progressing after radiotherapy and/or treatment with oxaliplatin or irinotecan; and metastasis thereof comprising administering to said animal a therapeutically effective amount of an epothilone derivative of formula (I).

    COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF
    7.
    发明公开
    COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF 有权
    埃博霉素含组合及其药物用途

    公开(公告)号：EP1515750A1

    公开(公告)日：2005-03-23

    申请号：EP03757040.5

    申请日：2003-06-06

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： HOHNEKER, John, Arthur ,  MILLER, Julie, Ann ,  ROTHERMEL, John, David ,  WARTMANN, Markus

    IPC分类号： A61K45/06 ,  A61K39/395 ,  A61K31/426 ,  A61K31/427 ,  A61P35/00

    CPC分类号： C07K16/3015 ,  A61K31/426 ,  A61K31/427 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07D417/06 ,  A61K2300/00

    摘要： The invention relates to a pharmaceutical combination which comprises (a) a HER-1 or a HER-2 antibody or (b) at least one antineoplastic agent selected from the group consisting of aromatase inhibitors, antiestrogens, topoisomerase I inhibitors, topoisomerase II inhibitors, microtubule active agents, protein kinase C inhibitors, anti-angiogenic compounds, gonadorelin agonists, anti-androgens, histone deacetylase inhibitors and S-adenosyl-methionine decarboxylase inhibitors; and (c) an epothilone derivative of formula (I), and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular, for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.

    COMBINATIONS COMPRISING EPOTHILONES AND ANTI-METABOLITES
    10.
    发明公开
    COMBINATIONS COMPRISING EPOTHILONES AND ANTI-METABOLITES 审中-公开
    WITH霉素和抗代谢物组合

    公开(公告)号：EP1469847A1

    公开(公告)日：2004-10-27

    申请号：EP03729249.7

    申请日：2003-01-13

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： HOHNEKER, John, Arthur ,  MCSHEEHY, Paul, M., J. ,  ROTHERMEL, John, David

    IPC分类号： A61K31/427 ,  A61K31/513 ,  A61K31/7068 ,  A61P35/00

    CPC分类号： A61K31/427 ,  A61K31/513 ,  A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00

    摘要： Disclosed is a combination which comprises (a) an antineoplastic antimetabolite and (b) an epothilone derivative of formula (I), wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, R' is methyl, methoxy, ethoxy, amino, methylamino, dimethylamino, aminomethyl or methylthio, and Z is O or a bond, and optionally at least one pharmaceutically acceptable carrier and/or, optionally, a standard anti-diarrheal, for simultaneous, separate or sequential use, in particular for the treatment of a proliferative disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal.