专利检索 ap:("Pharmasset, Inc.") AND inv:"DU, Jinfa" 第 2 页

11.

发明公开
PREPARATION OF 2'FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES 审中-公开
标题翻译：制造'氟代-2'-烷基取代或以其他方式可选取代核糖基嘧啶和嘌呤及其衍生物

公开(公告)号：EP1809301A2

公开(公告)日：2007-07-25

申请号：EP05808357.7

申请日：2005-09-13

申请人： Pharmasset, Inc.

发明人： CHUN, Byoung-Kwon , WANG, Peiyuan , DU, Jinfa , RACHAKONDA, Suguna

IPC分类号： A61K31/7072

摘要： The present invention provides (i) processes for preparing a 2'-deoxy-2'fluoro-2'-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methyl-ss-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.