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公开(公告)号：EP3155400B1
公开(公告)日：2020-03-04
申请号：EP15728016.5
申请日：2015-06-12
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公开(公告)号：EP3380236A1
公开(公告)日：2018-10-03
申请号：EP16801508.9
申请日：2016-11-25
发明人： BOEHM, Christoph , BRUECKNER, Thorsten , FISCHER, Thomas , LOPEZ-CALLE, Eloisa , LUTZ, Sascha , ROEDL, Josef , SPINKE, Juergen , ESPINDOLA, Pamela , KELLER, Thomas Manuel , DOLBINOW, Thomas , ADLER, Sabrina , BEIERSDORF, Erik , WENSORRA, Domenik
CPC分类号： B01L3/502753 , B01L3/5023 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/16 , B01L2300/0627 , B01L2300/0803 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/084 , G01N35/00069 , G01N2035/1032
摘要： The invention provides for a medical system (700) for determining a quantity of an analyte (602, 602') in a blood sample (600) using a cartridge (100). The medical instrument comprises the cartridge. The cartridge is operable for being spun around a rotational axis (102), wherein the cartridge comprises: an inlet (108) for receiving the blood sample; a blood separation chamber (118) for separating blood plasma from the blood sample, wherein the blood separation chamber is fluidically connected to the inlet; a processing chamber (124) containing at least one reagent comprising at least one specific binding partner (611) which is operable to bind to the analyte to form at least one analyte specific binding partner complex; a first valve structure (122) connecting the blood separation chamber to the processing chamber; a measurement structure (130) for enabling measurement of the quantity of the analyte, wherein the measurement structure comprises a chromatographic membrane (134), wherein the chromatographic membrane comprises an immobilized binding partner (620) for direct or indirect binding of the analyte or the at least one analyte specific binding partner complex, wherein the measurement structure further comprises an absorbent structure (132), wherein the absorbent structure is nearer to the rotational axis than the membrane; a second valve structure (128) connecting the processing chamber to the measurement structure; and a fluid chamber (136, 136') filled with a washing buffer (1202), wherein the fluid chamber is fluidically connected to the measurement structure, wherein a seal keeps the washing buffer with the fluid chamber.
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公开(公告)号：EP3324189A1
公开(公告)日：2018-05-23
申请号：EP16199213.6
申请日：2016-11-16
发明人： BOEHM, Christoph , LUTZ, Sascha , KELLER, Thomas
CPC分类号： G01N35/00584 , B01L3/5027 , B01L3/502753 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/0803 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , G01F13/00 , G01N33/5005 , G01N35/00 , G01N35/00069 , G01N35/1016 , G01N2035/00495
摘要： The invention provides for a cartridge (100) for determining an amount of at least two analytes in a biological sample. The cartridge comprises a cartridge inlet (104) for receiving the biological sample. The cartridge further comprises a sample holding chamber (106) fluidically connected to the cartridge inlet. The cartridge further comprises two or more metering chambers (116, 118, 120) for the biological sample for receiving a predetermine volume of the biological sample. Each of the two or more metering chambers comprises a sample inlet (122), a sample outlet (124), and a metered outlet (126) for dispensing a predetermined volume. The cartridge further comprises a connecting tube (128) for each of the two or more metering chambers that fluidically connects the sample inlet with the sample holding chamber. The cartridge further comprises at least one sample distribution channel (132) that is connected between the sample outlet of a first selected metering chamber with a sample inlet of a second selected metering chamber. The cartridge further comprises a microfluidic structure (800) for each of the two or more metering chambers. The microfluidic structure is connected to the sample outlet. The microfluidic structure is configured for processing sample into a processed sample. The cartridge further comprises a measurement structure (804) for each of the two or more metering chambers for enabling measurement of the processed sample to determine the amount of the analyte in the processed sample. The measurement structure is fluidically connected to the microfluidic structure.
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14.发明公开ROTATABLE CARTRIDGE WITH A METERING CHAMBER FOR ANALYZING A BIOLOGICAL SAMPLE 有权DREHBARE KARTUSCHE MIT EINER DOSIERKAMMER ZUR ANALYZE EINER BIOLOGISCHEN PROBE
公开(公告)号：EP3151963A1
公开(公告)日：2017-04-12
申请号：EP15729512.2
申请日：2015-06-18
发明人： BOEHM, Christoph , LUTZ, Sascha , SPINKE, Jürgen
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/044 , B01L2300/0672 , B01L2300/0803 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2300/0883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/0694 , G01N1/38 , G01N35/00069 , G01N35/1016 , G01N2035/00257 , G01N2035/1032
摘要： An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. Capillary action next to the side walls is greater than in the central region. A circular arc about the rotational axis passes through a duct entrance in the aliquoting chamber and a duct exit in the metering chamber. The cartridge has a downstream fluidic element which is part of a fluidic structure for processing a biological sample into the processed biological sample. A valve connects the metering chamber to the fluidic element, which is fluidically connected to the fluidic structure. The fluidic structure receives the biological sample and has a measurement structure for enabling measurement of the processed biological sample.
摘要翻译： 可旋转轴线旋转的自动分析器盒具有等分量和计量室，其间连接管道和连接到计量室的通风口，并且比计量室更靠近旋转轴线。 计量室具有从中心区域逐渐变细的侧壁。 侧壁旁边的毛细管作用大于中部地区。 围绕旋转轴的圆弧通过等分室中的管道入口和计量室中的管道出口。 药筒具有下游流体元件，其是用于将生物样品加工成经处理的生物样品的流体结构的一部分。 阀将计量室连接到与流体结构流体连接的流体元件。 流体结构接收生物样品并具有用于能够测量经处理的生物样品的测量结构。
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15.发明公开ROTATABLE CARTRIDGE FOR PROCESSING AND ANALYZING A BIOLOGICAL SAMPLE 审中-公开DREHBARE PATRONE ZUR VERARBEITUNG UNDANALYZE EINER BIOLOGISCHEN PROBE
公开(公告)号：EP3151962A1
公开(公告)日：2017-04-12
申请号：EP15725384.0
申请日：2015-06-03
发明人： BOEHM, Christoph , LUTZ, Sascha , SPINKE, Jürgen
CPC分类号： B01L3/50273 , B01L3/502723 , B01L3/502738 , B01L2200/04 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/043 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0803 , B01L2300/087 , B01L2300/0883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/0694 , G01N1/38 , G01N35/00069 , G01N35/1016 , G01N2035/00247 , G01N2035/00257 , G01N2035/1032 , G01N2035/1034
摘要： The invention provides for a cartridge (300) for an automatic analyzer (1100), wherein the cartridge is operable for being spun around a rotational axis (102). The cartridge comprises: a fluid chamber (104) for receiving a fluid (307), an aliquoting chamber (108), a first duct (106) connecting the fluid chamber and the aliquoting chamber, a metering chamber (112) operable for causing fluid to fill the metering chamber using capillary action, and a second duct (110) connecting the metering chamber with the aliquoting chamber, wherein the second duct comprises a duct entrance (114) in the aliquoting chamber. The second duct further comprises a duct exit (116) in the metering chamber wherein the duct exit is closer to the rotational axis than the duct entrance. The second duct is operable for causing fluid to flow to the metering chamber using capillary action. The cartridge further comprises a downstream fluidic element (122) connected to the metering chamber via a valve (121) and a fluidic structure (336) for processing a biological sample into the processed biological sample. The fluidic structure comprises a measurement structure (344, 1110) for enabling measurement of the processed biological sample, wherein the fluidic structure is configured for receiving the biological sample.
摘要翻译： 本发明提供了一种用于自动分析器（1100）的盒（300），其中盒可操作以围绕旋转轴线（102）旋转。 所述筒包括：用于接收流体（307）的流体室（104），等分室（108），连接所述流体室和所述等分室的第一管道（106），可操作以引起流体 以使用毛细管作用填充计量室，以及将计量室与等分池连接的第二管道（110），其中第二管道包括等分室中的管道入口（114）。 第二管道还包括在计量室中的管道出口（116），其中管道出口比管道入口更靠近旋转轴线。 第二管道可操作以使流体使用毛细管作用流到计量室。 墨盒还包括经由阀（121）和流体结构（336）连接到计量室的下游流体元件（122），用于将生物样品处理成经处理的生物样品。 流体结构包括用于能够测量经处理的生物样品的测量结构（344,1110），其中流体结构被配置为用于接收生物样品。
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16.发明公开ROTATABLE CARTRIDGE FOR MEASURING A PROPERTY OF A BIOLOGICAL SAMPLE 审中-公开DREHBARE KARTUSCHE ZUR MESSUNG EINER EIGENSELLSCHAFT EINER BIOLOGISCHEN PROBE
公开(公告)号：EP3143412A1
公开(公告)日：2017-03-22
申请号：EP15721222.6
申请日：2015-05-07
发明人： BOEHM, Christoph , LUTZ, Sascha , DOLBINOW, Thomas
摘要： The invention provides for a cartridge (100, 200, 2100) for an automatic analyzer (2200). The cartridge is operable for being spun around a rotational axis (102) and has at least one container (106) with at least one fluid reservoir (108, 202) containing at least one fluid (110, 204). Each container is configured to rotate about the rotational axis of within a cavity (104, 104') and relative to the cartridge. Each fluid reservoir comprises a pierceable seal (112) and cavity comprises at a piercing structure (114) for each fluid reservoir. The piercing structure is configured to open the seal when the container is rotated relative to the cartridge. Each container has a first frictional element (412) and each cavity has a second frictional element (414) that mate and cause friction. Each container comprises a first engaging surface (406) operable for mating with a second engaging surface (408) of a rotational actuator operable for applying torque to the container. The cartridge comprises a fluidic structure (120, 2116, 2117, 2118, 2120, 2121, 2122, 2123, 2124, 2125, 2130, 2131, 2132, 2133, 2134, 2135) for processing a biological sample into the processed biological sample. There is a duct (116) between the cavity and the fluidic structure. The fluidic structure comprises a measurement structure (2219, 2210) for enabling the measurement of the processed biological sample.
摘要翻译： 本发明提供一种用于自动分析仪（2200）的盒（100,200,2100）。 所述筒可操作以围绕旋转轴线（102）旋转，并具有至少一个容器（106），所述至少一个容器具有至少一个包含至少一种流体（110,204）的流体储存器（108,202）。 每个容器构造成围绕空腔（104,104'）内的旋转轴线和相对于盒子转动。 每个流体储存器包括可刺穿的密封件（112），并且空腔包括用于每个流体储存器的穿孔结构（114）。 穿孔结构构造成当容器相对于盒旋转时打开密封件。 每个容器具有第一摩擦元件（412），并且每个空腔具有配合并引起摩擦的第二摩擦元件（414）。 每个容器包括可操作以与可操作以向容器施加扭矩的旋转致动器的第二接合表面（408）配合的第一接合表面（406）。 该盒包括用于将生物样品加工成经处理的生物样品的流体结构（120,2116,2117,2118,2120,2121,2122,2123,2124,2125,2130,2131,2132,2133,2143,2133）。 在空腔和流体结构之间有管道（116）。 流体结构包括用于能够测量经处理的生物样品的测量结构（2219,2210）。
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公开(公告)号：EP3143412B1
公开(公告)日：2019-12-18
申请号：EP15721222.6
申请日：2015-05-07
发明人： BOEHM, Christoph , LUTZ, Sascha , DOLBINOW, Thomas
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公开(公告)号：EP3380236B1
公开(公告)日：2019-08-28
申请号：EP16801508.9
申请日：2016-11-25
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公开(公告)号：EP3524982A1
公开(公告)日：2019-08-14
申请号：EP19160587.2
申请日：2007-09-27
IPC分类号： G01N33/543 , B01L3/00
摘要： Die Erfindung betrifft ein Testelement, das im Wesentlichen scheibenförmig und eben ist und um eine Achse, die senkrecht zur scheibenförmigen Testelementebene liegt, rotierbar ist, enthaltend eine Probenaufgabeöffnung zur Aufgabe einer flüssigen Probe, eine kapillaraktive Zone, insbesondere eine poröse, saugfähige Matrix, mit einem achsenfernen ersten Ende und einem achsennahen zweiten Ende, und einen Probenkanal, der von einem achsennahen Bereich zum achsenfernen ersten Ende der kapillaraktiven Zone reicht. Weiterhin betrifft die Erfindung ein Verfahren zur Bestimmung eines Analyten mit Hilfe des Testelements.
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公开(公告)号：EP3184158B1
公开(公告)日：2019-01-16
申请号：EP15201585.5
申请日：2015-12-21
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