公开(公告)号：EP2214025B1

公开(公告)日：2018-12-26

申请号：EP08845860.9

申请日：2008-10-27

申请人： PHC Holdings Corporation

发明人： SAIKI, Hiroshi ,  FUJII, Yoshiyuki ,  HIGASHI, Nobuyasu ,  KITOH, Masaaki ,  OKADA, Kenji ,  SUGIMOTO, Hirofumi

IPC分类号： G01N35/00 ,  G01N37/00 ,  B01L3/00

CPC分类号： G01N33/50 ,  B01L3/50 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/0803 ,  B01L2300/0867 ,  B01L2400/0409 ,  B01L2400/0683 ,  B04B7/00 ,  B04B7/02 ,  G01N1/28 ,  G01N21/07 ,  G01N33/4875 ,  G01N33/49 ,  G01N33/4915 ,  G01N35/025 ,  G01N2035/00504 ,  G01N2035/0403 ,  G01N2035/1032 ,  Y10T436/11 ,  Y10T436/111666

摘要： A protective cap 2 is engaged with a latch 10 of a diluent container 5 so as to fix the diluent container 5 at a liquid holding position of a diluent container containing section 11. The engagement is released when the protective cap 2 is set to an open position against the engagement so as to expose an inlet 13. When the protective cap 2 is shifted from the open position to a closed position, the protective cap 2 pushes the diluent container 5 into a liquid discharge position. Thus, it is possible to preserve a diluent for a long period of time and to easily open the diluent container 5 without having to complicate the structure of an analysis apparatus.

公开(公告)号：EP2904399B1

公开(公告)日：2018-12-05

申请号：EP13779693.4

申请日：2013-10-07

申请人： General Electric Company

发明人： MELANSON, Paul Charles ,  GODEC, Richard Douglas ,  STONESMITH, Matthew Kaddeland ,  SMITH, Darren Barry ,  SUN, Chao

IPC分类号： G01N33/579 ,  B01L3/00

CPC分类号： G01N33/56911 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/5085 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/021 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0622 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N21/17 ,  G01N33/579 ,  G01N2400/10 ,  G01N2400/50 ,  Y10T436/2575

摘要： A test substrate for detecting a LAL-reactive substance, wherein at least a portion of said test substrate has been pre-loaded with at least one LAL reagent and/or at least one LAL-reactive standard. Methods of use of the test substrate are disclosed. Methods of depositing test reagents on a test substrate are also disclosed.

公开(公告)号：EP3254761B1

公开(公告)日：2018-11-14

申请号：EP17182672.0

申请日：2012-09-03

申请人： Eppendorf AG

发明人： David, Sandra ,  Grune, Sylke

IPC分类号： B01L9/00 ,  B04B5/04

CPC分类号： B01L9/523 ,  B01L3/5085 ,  B01L2300/0829 ,  B01L2400/0409 ,  B04B5/0421 ,  B04B2005/0435

公开(公告)号：EP3158334B1

公开(公告)日：2018-10-17

申请号：EP15735866.4

申请日：2015-06-19

申请人： Spinchip Diagnostics AS

发明人： BORCH, Stig Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein Geir ,  GULLIKSEN, Anja

IPC分类号： G01N33/543

CPC分类号： G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

摘要： The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d>m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

公开(公告)号：EP3244999B1

公开(公告)日：2018-09-19

申请号：EP16700356.5

申请日：2016-01-12

申请人： Dublin City University

发明人： DUCREE, Jens ,  GLYNN, Macdara ,  NWANKIRE, Charles

IPC分类号： B01L3/00 ,  G01N15/00 ,  G01N35/00 ,  G01N15/02

CPC分类号： B01L3/502761 ,  B01L3/5025 ,  B01L3/50273 ,  B01L2200/0652 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2400/0409 ,  G01N15/0272 ,  G01N35/00069 ,  G01N2015/0053 ,  G01N2015/0288

摘要： Microfluidic devices that are configured to use centrifugal forces to bias particles into one or more capture regions based on their individual sizes are described.

公开(公告)号：EP2853310B1

公开(公告)日：2018-09-12

申请号：EP13793579.7

申请日：2013-04-09

申请人： Korea Advanced Institute Of Science And Technology

发明人： CHO, Young-ho ,  KANG, Yoon-tae

IPC分类号： B04B7/08 ,  B04B5/02 ,  B04B11/00 ,  B01L3/00

CPC分类号： B01L3/5082 ,  B01D21/262 ,  B01D21/28 ,  B01L3/5021 ,  B01L3/50215 ,  B01L9/00 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2400/0409 ,  B01L2400/0478 ,  B01L2400/0638 ,  B01L2400/065

摘要： A separation container includes a separation tube receiving a sample therein, a first sedimentation part connected to an end portion of the tube, a particle in the sample being deposited by a centrifugal or agitating force, and a separating part provided in the tube and including at least one separating layer which selectively opens and closes the tube.

公开(公告)号：EP2648849B1

公开(公告)日：2018-08-22

申请号：EP10805540.1

申请日：2010-12-09

申请人： Isens - Electrónica, Lda.

发明人： GONÇALVES GUEDES, Pedro Ernesto

IPC分类号： B04B5/04 ,  B01L99/00

CPC分类号： B04B5/02 ,  B01L3/0293 ,  B01L3/5021 ,  B01L2400/0409 ,  B04B5/0414 ,  B04B5/0421

摘要： The present invention relates to a method and device for separating and transferring container (1) contents by dynamical use of centrifuge force, transferring a specific volume of liquid (A) from a recipient (1) to another (2) without contact with any external element other than the initial container (1) itself. Therefore, the present invention is useful for transferring for example part of a blood sample (A) from a tube (1) without touching the blood sample, also dispensing with a disposable needle as is currently usual. The invention is also advantageous as it allows keeping in the original container (1) a predetermined portion of the sample (B). By rotating the container, with a sufficiently high speed, over an axis (x) located at the boundary of the parts (A, B), the sample is split at a predetermined position. A preferred embodiment comprises the container at an angle (V) to the rotation axis (x).

公开(公告)号：EP3329992A1

公开(公告)日：2018-06-06

申请号：EP17199662.2

申请日：2017-11-02

申请人： SYSMEX CORPORATION

发明人： HORII, Kazuyoshi ,  FUJIWARA, Takao ,  NOSE, Tomoyuki

IPC分类号： B01L3/00

CPC分类号： B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2400/0409 ,  B01L2400/0475 ,  B01L2400/0683 ,  B01L2400/0688 ,  B65B3/12 ,  G01N21/76 ,  G01N33/491 ,  G01N35/00069 ,  G01N35/0098 ,  G01N2035/00089 ,  G01N2035/00495

摘要： Disclosed is a liquid sealed cartridge in which a liquid injected through an inlet is previously sealed, and the liquid is transferred by a centrifugal force being applied by rotation, and the liquid sealed cartridge includes: a liquid storage portion configured to store the liquid; a bypass flow path having one end and the other end connected to the liquid storage portion, the bypass flow path having the inlet; and a transfer flow path into which the liquid is transferred from the liquid storage portion when the centrifugal force is applied.

公开(公告)号：EP3326718A1

公开(公告)日：2018-05-30

申请号：EP18151225.2

申请日：2014-10-07

申请人： Yantai AusBio Laboratories Co., Ltd.

发明人： Mann, Wolfgang ,  Wang, Zhaoqiang

IPC分类号： B01L3/00 ,  G01N21/00 ,  G01N33/543

CPC分类号： G01N33/5304 ,  B01L3/5025 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0858 ,  B01L2400/0409 ,  G01N21/253 ,  G01N21/82 ,  G01N33/54366

摘要： The invention relates to a microplate used in a method for determining the result of an agglutination reaction.
Agglutinated and non-agglutinated sample material is separated by means of a separation material such as gel material or a bead matrix in a centrifugation step. Whether an agglutination reaction took place or not is determined by comparing the color intensities and/or the gray levels of images of the top side and the bottom side of the respective reaction vessel. Comparing the color intensities and/or the gray levels of 20 the two images makes the automatic determination reliable and stable. Furthermore, the reaction wells are arranged in a two-dimensional array which provides a high throughput.

公开(公告)号：EP2458381B1

公开(公告)日：2018-05-30

申请号：EP12001206.7

申请日：2003-10-02

申请人： Battelle Memorial Institute

发明人： Haubert, Thomas ,  Wardlaw, Stephen

IPC分类号： B01L3/14 ,  B01L3/00 ,  G01N33/49

CPC分类号： B01L3/505 ,  B01L3/50215 ,  B01L2400/0409 ,  G01N33/49 ,  Y10S435/81 ,  Y10S436/81

摘要： The invention provides a buffy float for use in a tube and float system for use in separation and axial expansion of a buffy coat. The system includes a transparent, or semi-transparent, flexible sample tube (130) and a rigid separator float (110) having a specific gravity intermediate that of red blood cells and plasma. The sample tube has an elongated sidewall (136) having a first cross-sectional inner diameter. The float consists of a main body portion and one or more support members protruding from the main body portion to engage and support the sidewall of the sample tube. The main body portion and the support members of the float have a cross-sectional diameter less than that of the first cross-sectional inner diameter of the tube (138) when the sample tube is expanded, such as by centrifugation. The main body portion of the float together with an axially aligned portion of the sidewall define an annular volume therebetween. The support members protruding from the main body portion of the float traverse said annular volume to produce one or more analysis areas. During centrifugation, the centrifugal force enlarges the diameter of the tube to permit density-based axial movement of the float in the tube. Thereafter, the centrifugal force is reduced to cause the tube sidewall to return to its first diameter, thereby capturing the float and trapping the buffy coat constituents in the analysis area.