公开(公告)号：EP1032569A1

公开(公告)日：2000-09-06

申请号：EP98955672.5

申请日：1998-11-17

申请人： Sanofi-Synthélabo

发明人： COURTEMANCHE, Gilles ,  DEFOSSE, Gérard ,  CRESPIN, Olivier ,  BOVY, Philippe, R.

IPC分类号： C07D401/12 ,  C07D451/02 ,  C07D401/14 ,  C07D451/14

CPC分类号： C07D451/02 ,  C07D401/12 ,  C07D401/14

摘要： The invention concerns a compound of formula (I) in which: A represents a saturated or unsaturated heterocycle comprising a nitrogen atom of formula (B), (D), (E), or (F), R1 and R2, independently of each other, represent a hydrogen, a C1-6 alkyl group, or together form a polymethylene group -(CH2)n-, n representing values between 3 and 6, R5 represents a phenyl or a 2-, 3- or 4-pyridine, the phenyl or the pyridine being substituted by R3 and R'3, R6 represents a phenyl or a 2-, 3- or 4-pyridine the phenyl or the pyridine being substituted by R and R'4, and R7 represents a hydrogen atom or a C1-2 alkyl group. The invention is applicable in therapy.

公开(公告)号：EP2807172B1

公开(公告)日：2016-11-30

申请号：EP13712331.1

申请日：2013-01-25

申请人： SANOFI

发明人： BRAUN, Alain ,  CRESPIN, Olivier ,  FORICHER, Yann ,  MARCINIAK, Gilbert ,  MUZET, Nicolas ,  NICOLAI, Eric ,  PASCAL, Cécile ,  VIVET, Bertrand ,  VIVIANI, Fabrice

IPC分类号： C07D498/04 ,  A61K31/519

CPC分类号： C07D498/04 ,  C07D519/00

公开(公告)号：EP2807172A1

公开(公告)日：2014-12-03

申请号：EP13712331.1

申请日：2013-01-25

申请人： SANOFI

发明人： BRAUN, Alain ,  CRESPIN, Olivier ,  FORICHER, Yann ,  MARCINIAK, Gilbert ,  MUZET, Nicolas ,  NICOLAI, Eric ,  PASCAL, Cécile ,  VIVET, Bertrand ,  VIVIANI, Fabrice

IPC分类号： C07D498/04 ,  A61K31/519

CPC分类号： C07D498/04 ,  C07D519/00

摘要： The invention relates to bicydic heterocyclic derivatives of general formula (I) to a process for preparing them and to the therapeutic use thereof.

摘要翻译： 本发明涉及通式（I）的双二元杂环衍生物及其制备方法及其治疗用途。

公开(公告)号：EP2364311B1

公开(公告)日：2013-07-03

申请号：EP09760218.9

申请日：2009-10-27

申请人： SANOFI

发明人： BRAUN, Alain, Jean ,  CRESPIN, Olivier ,  NICOLAI, Eric ,  PASCAL, Cécile ,  VENIER, Olivier

IPC分类号： C07D451/02 ,  C07D451/06 ,  C07D471/08 ,  A61K31/496 ,  A61P3/00 ,  A61P9/00 ,  A61P19/00 ,  A61P25/00

CPC分类号： C07D451/06 ,  C07D451/02 ,  C07D471/08 ,  C07D487/08

公开(公告)号：EP1773796B1

公开(公告)日：2010-03-03

申请号：EP05790990.5

申请日：2005-07-20

申请人： Sanofi-Aventis

发明人： BRAUN, Alain ,  COURTEMANCHE, Gilles ,  CRESPIN, Olivier ,  FETT, Eykmar ,  PASCAL, Cécile

IPC分类号： C07D295/108 ,  C07D451/04 ,  A61K31/445 ,  A61P15/00

CPC分类号： C07D295/104 ,  C07D401/06 ,  C07D405/14 ,  C07D451/04 ,  C07D453/02

摘要： The invention concerns oxopiperidine derivatives of general formula (I) wherein: n = 1; Ra, Ra′, Rb et Rb′ represent hydrogen atoms or alkyl or cycloalkyl groups, or Rb and Rb′ together form a carbon bridge; R1 represents an alkyl or cycloalkyl group; R2 represents a heteroaryl group; R3 represents 1 to 3 groups selected among halogen atoms and alkyl, cycloalkyl, -OR, -NRR', -CO-NRR', -NR-CO-R', -NR-CO-NRR1, -NR-COOR', -NO2, -CN and COOR groups; R5 represents a hydrogen atom or an alkyl group; R4 is selected among the groups of formulae (a), (b) and (c), wherein p = 0, 1, 2 or 3, m = 0, 1 or 2, and X represents a -C(R6)(R7)- or -N(R10)- member. The invention also concerns a method for preparing said derivatives and their therapeutic use.

公开(公告)号：EP1786809A2

公开(公告)日：2007-05-23

申请号：EP05790800.6

申请日：2005-07-20

申请人： Sanofi-Aventis

发明人： BRAUN, Alain ,  CORNET, Bruno ,  COURTEMANCHE, Gilles ,  CRESPIN, Olivier ,  FETT, Eykmar ,  PASCAL, Cécile

IPC分类号： C07D451/04 ,  C07D453/02 ,  A61K31/4468 ,  A61K31/439 ,  C07D401/12 ,  C07D405/12 ,  C07D401/14 ,  A61P15/10 ,  C07D211/58

CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D451/04 ,  C07D453/02

摘要： The invention concerns aminopiperidine derivatives of general formula (I) wherein: Ra, Ra' and R5 represent hydrogen atoms or alkyl groups; R1 represent a hydrogen atom and an alkyl, cycloalkyl, heterocycloalkyl or aryl group; R2 represents a group of formula -(CH2)x-(CO)y-Y or -(CO)y-(CH2)x-Y, wherein Y represents a hydrogen atom or a hydroxy, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl or NR 11R12 group, Y being other than a hydrogen atom when x = y = 0; R3 represents 1 to 3 groups selected among halogen atoms and alkyl, cycloalkyl, -OR, -NRR', -CO-NRR', -NR-CO-R', -NR-CO-NRR', -NR-COOR', -NO2, -CN and COOR groups; R4 is selected among groups of formula (a), (b) and (c), wherein p = 0, 1, 2 or 3, m = 0, 1 or 2; X represents an oxygen or sulphur atom or a -C(R 6)(R7)- or -N(R10)- member. The invention also concerns a method for preparing said derivatives and their therapeutic use as melanocortin receptor agonists for treating obesity, diabetes, sexual dysfunction.