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11.发明授权SUBSTITUIERTE 8,8a-DIHYDRO-3aH-INDENO 1,2-d]THIAZOLE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权取代8,8a二氢3A茚并1,2-D]噻唑，其制造方法相同，并且它们作为药物
公开(公告)号：EP1263746B1
公开(公告)日：2005-12-28
申请号：EP01903742.3
申请日：2001-02-12
IPC分类号： C07D277/60 , A61K31/425
CPC分类号： C07D277/60
摘要： The invention relates to substituted 8, 8a-dihydro-3aH-indeno[1,2-d]thiazoles and to their physiologically compatible salts and physiologically functional derivatives. The invention relates to compounds of formula (I), wherein the groups have the given meanings, to their physiologically compatible salts and to a method for their production. The compounds are, for example, suitable for use as anorectic agents.
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12.发明授权SÄUREGRUPPEN SUBSTITUIERTE DIPHENYLAZETIDINONE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG 有权ACID取代Diphenylazetidinones，方法及其，药品含有它们及其用途
公开(公告)号：EP1517891B1
公开(公告)日：2013-04-03
申请号：EP03735535.1
申请日：2003-06-04
发明人： JAEHNE, Gerhard , FRICK, Wendelin , FLOHR, Stefanie , LINDENSCHMIDT, Andreas , GLOMBIK, Heiner , KRAMER, Werner , HEUER, Hubert , SCHAEFER, Hans-Ludwig
IPC分类号： C07D205/08 , C07F9/568 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07F9/568 , C07D205/08 , C07F9/5683
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13.发明授权NEUE CYANOPYRROLIDIDE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权新氰基吡咯烷，其制造方法相同，它们作为药物
公开(公告)号：EP1651649B1
公开(公告)日：2010-12-01
申请号：EP04740981.8
申请日：2004-07-14
发明人： SCHOENAFINGER, Karl , WAGNER, Holger , JAEHNE, Gerhard , GAUL, Holger , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D487/04 , A61K31/415
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I) wherein the radicals have the designations cited in the text. The invention also relates to the stereoisomer forms and the physiologically compatible salts thereof, the physiologically functional derivatives thereof, and methods for producing the same. The inventive compounds are suitable for treating illnesses of the metabolism such as type 2 diabetes.
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14.发明授权
公开(公告)号：EP1425264B1
公开(公告)日：2008-10-29
申请号：EP02772163.8
申请日：2002-08-17
IPC分类号： C07C317/20 , C07C323/17 , A61K31/10 , A61P3/04
CPC分类号： C07C323/17 , C07C317/20 , C07C2602/08
摘要： The invention relates to C2-disubstituted indane-1-ol systems and to their physiologically compatible salts and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the groups are defined as per the description, to their physiologically compatible salts and to a method for the production of said compounds. The compounds are suitable for use e.g. as anorexiants.
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15.发明授权
公开(公告)号：EP1756049B1
公开(公告)日：2007-10-31
申请号：EP05747892.7
申请日：2005-05-20
发明人： LINDENSCHMIDT, Andreas , WILL, David, William , JAEHNE, Gerhard , WOLLMANN, Theodor, Andreas , FRICK, Wendelin , JUNKER, Bernd , RIGAL, David , BILLEN, Guenter , JENDRALLA, Heiner
IPC分类号： C07D205/08
CPC分类号： C07D205/08 , A61K31/33
摘要： The invention relates to a method for producing 1,4-diphenyl azetidinone derivatives from suitably protected β-substituted amino amides, in the presence of silylation agents. Said method uses cyclization catalysts that comprise phosphonium ions as the cation of formula (XII), and ions of the following general formulas (a), (b), (c) or (d) as the anion. In said formulas, the symbols, substituents and indices are defined as follows: Z = C=O, C=S, S=O, SO2 or C=NR20; K = O, S, NR21 or CR22R23; L = NR24 or CR25R26; n = 0 or 1; M = O, C=O, NR27 or CR28R29; Q = O, S, NR30, CR31R32, C=O, C=S, S=O, SO2 or C=NR34; R = CR35 or N; T = CR36 or N; U = CR37 or N; V = CR38 or N; the groups R16 to R19 can represent, for example, aryl or (C1-C15) alkyl, aryl(C1-C10)alkene, and the groups R20 to R32 and R34 to R38 can represent in addition H or heteroaryl; R39 and R40 represent, for example (C1-C6) alkyl. The anion can also be R41O-, R42COO- or Cl-, Br- or I- (combined with Ag2O).
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16.发明公开SUBSTITUIERTE, BIZYKLISCHE 8-PYRROLIDINO-XANTHINE UND IHRE VERWENDUNG ALS INHIBITOREN DER DIPEPTIDYL PEPTIDASE IV 审中-公开取代的双环8吡咯烷基黄嘌呤及其作为二肽基肽酶IV抑制剂的
公开(公告)号：EP1778697A1
公开(公告)日：2007-05-02
申请号：EP05775931.8
申请日：2005-07-22
发明人： SCHOENAFINGER, Karl , JAEHNE, Gerhard , DEFOSSA, Elisabeth , SCHWINK, Lothar , WAGNER, Holger , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D519/00 , A61K31/522
CPC分类号： C07D519/00
摘要： The invention relates to substituted, bicyclic 8-pyrrolidino-xanthines, to the physiologically compatible salts thereof and to the physiologically functional derivatives thereof. The invention also relates to compounds of formula (I), wherein the groups have the meaning cited in the description, in addition to the physiologically compatible salts thereof. The compounds can be used, for example, as medicaments for the prevention and treatment of type 2 diabetes.
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17.发明授权NEUE DIPHENZYLAZETIDINONE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG ZUR BEHANDLUNG VON LIPIDSTOFFWECHSELSTÖRUNGEN 有权新DIPHENZYLAZETIDINONE，方法及其，药品含有它们的它们用于脂质代谢紊乱的治疗
公开(公告)号：EP1345895B1
公开(公告)日：2006-12-27
申请号：EP01271353.3
申请日：2001-12-11
发明人： GLOMBIK, Heiner , KRAMER, Werner , FLOHR, Stefanie , FRICK, Wendelin , HEUER, Hubert , JAEHNE, Gerhard , LINDENSCHMIDT, Andreas , SCHAEFER, Hans-Ludwig
IPC分类号： C07D205/08 , A61K31/395 , A61P3/06
CPC分类号： C07F7/186 , C07D205/08
摘要： The invention relates to the compounds of the formula (I), wherein R1, R2, R3, R4, R5, and R6 have the cited meanings, and to their physiologically acceptable salts. The inventive compounds are suitable, for example, as hypolipidemics.
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18.发明授权VERWENDUNG VON C2-SUBSTITUIERTEN INDAN-1-OL-SYSTEMEN ZUR HERSTELLUNG VON MEDIKAMENTEN ZUR PROPHYLAXE ODER BEHANDLUNG VON OBESITAS 有权取代的C 2 - 茚满-1-醇系统，用于药物的用于治疗肥胖的预防和治疗生产使用
公开(公告)号：EP1425007B1
公开(公告)日：2005-11-02
申请号：EP02772165.3
申请日：2002-08-17
IPC分类号： A61K31/255 , A61P3/04
CPC分类号： A61K31/255
摘要： The invention relates to the use of C2-substituted indane-1-ol systems and to their physiologically compatible salts and physiologically functional derivatives for producing medicaments to promote weight loss in mammals and for the prophylaxis or treatment of obesity. The invention also relates to the use of compounds of formula (I), wherein the groups are defined as per the description, and to the physiologically compatible salts and physiologically functional derivatives of said compounds, for producing a medicament for the prophylaxis or treatment of obesity.
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19.发明授权VERWENDUNG VON MEHRFACH SUBSTITUIERTEN INDAN-1-OL-SYSTEMEN ZUR HERSTELLUNG VON MEDIKAMENTEN ZUR PROPHYLAXE ODER BEHANDLUNG VON OBESITAS 有权使用多取代茚-1-醇系统药物的肥胖的预防和治疗PRODUCTION
公开(公告)号：EP1425000B1
公开(公告)日：2012-08-01
申请号：EP02797584.6
申请日：2002-08-17
CPC分类号： A61K31/10 , A61K31/137 , A61K31/365 , A61K31/4184 , A61K38/2264 , A61K2300/00
摘要： The invention relates to the use of polysubstituted indan-1-ol systems and the physiologically acceptable salts and physiologically functional derivatives thereof for producing drugs used in the prophylaxis or treatment of obesity. The invention relates to the use of the compounds of formula (I), wherein the groups are defined as indicated, and to the physiologically acceptable salts and physiologically functional derivatives thereof for producing a drug used in the prophylaxis or treatment of obesity.
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20.发明授权C2-DISUBSTITUIERTE INDAN-1-ONE UND IHRE DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权C2二取代茚满-1-酮及其衍生物，用于生产及其作为药物
公开(公告)号：EP1423359B1
公开(公告)日：2010-07-14
申请号：EP02772164.6
申请日：2002-08-17
IPC分类号： C07C317/24 , C07C323/22 , A61K31/10 , A61P3/04
CPC分类号： C07C317/24 , C07C323/22 , C07C2602/08
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