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1.发明公开NEUE MIT CYCLOHEXYLRESTEN SUBSTITUIERTE1,4-BENZOTHIEPIN-1,1 -DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG 有权新配环己SUBSTITUIERTE1,4-苯并硫-1,1-二氧化物的衍生物，用于生产药物含有它们及其用途
公开(公告)号：EP2084143A1
公开(公告)日：2009-08-05
申请号：EP07819435.4
申请日：2007-10-30
发明人： FRICK, Wendelin , GLOMBIK, Heiner , THEIS, Stefan , HEUER, Hubert , SCHAEFER, Hans-Ludwig , KRAMER, Werner
IPC分类号： C07D337/08 , A61K31/08
CPC分类号： C07D337/08
摘要： The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. These compounds are suitable, for example, as hypolipidemics.
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2.发明授权NEUES DIPHENYLAZETIDINON MIT VERBESSERTEN PHYSIOLOGISCHEN EIGENSCHAFTEN, VERFAHREN ZU DESSEN HERSTELLUNG, DIESE VERBINDUNG ENTHALTENDE ARZNEIMITTEL UND DESSEN VERWENDUNG 有权具有改进的生理特性NEW diphenylazetidinone，生产工艺为那些相关的药物含及其用途
公开(公告)号：EP1613589B1
公开(公告)日：2008-02-13
申请号：EP04720854.1
申请日：2004-03-16
发明人： JAEHNE, Gerhard , FRICK, Wendelin , LINDENSCHMIDT, Andreas , FLOHR, Stefanie , HEUER, Hubert , SCHAEFER, Hans-Ludwig , KRAMER, Werner , GALIA, Eric , GLOMBIK, Heiner
IPC分类号： C07D205/08 , A61K31/397 , A61P3/06
CPC分类号： C07C233/18 , C07D205/08
摘要： The invention relates to a novel diphenyl azetidinone, to a method for its production, to medicaments containing said compound and to the use of the latter. The invention relates to the compound of general formula (I), in addition to its physiologically compatible salts. Said compound is suitable for use for example as a hypolipidaemic agent.
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公开(公告)号：EP1529061B1
公开(公告)日：2008-02-13
申请号：EP03784089.9
申请日：2003-07-28
发明人： KRAMER, Werner , FRICK, Wendelin
IPC分类号： C07K14/47
摘要： The invention describes a method for isolating an intestinal protein which is able to bind cholesterol and/or cholesterol uptake inhibitors.
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4.发明授权NEUE AROMATISCHE FLUORGLYCOSIDDERIVATE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG 有权香型FLUORGLYCOSIDDERIVATE，药品含有它们及其用途
公开(公告)号：EP1572707B1
公开(公告)日：2006-03-29
申请号：EP03795853.5
申请日：2003-11-28
发明人： FRICK, Wendelin , GLOMBIK, Heiner , KRAMER, Werner , HEUER, Hubert , BRUMMERHOP, Harm , PLETTENBURG, Oliver
IPC分类号： C07H15/203 , A61K31/70 , A61P3/10
CPC分类号： C07H15/203
摘要： The invention relates to substituted aromatic fluoroglycoside derivatives of a formula (1), wherein radicals have predefined bonds, to the psychologically tolerated salts thereof, and methods for the preparation thereof. Said compounds can be used, for example in the form of antidiabetic agents.
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5.发明授权SÄUREGRUPPEN SUBSTITUIERTE DIPHENYLAZETIDINONE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG 有权ACID取代Diphenylazetidinones，方法及其，药品含有它们及其用途
公开(公告)号：EP1517891B1
公开(公告)日：2013-04-03
申请号：EP03735535.1
申请日：2003-06-04
发明人： JAEHNE, Gerhard , FRICK, Wendelin , FLOHR, Stefanie , LINDENSCHMIDT, Andreas , GLOMBIK, Heiner , KRAMER, Werner , HEUER, Hubert , SCHAEFER, Hans-Ludwig
IPC分类号： C07D205/08 , C07F9/568 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07F9/568 , C07D205/08 , C07F9/5683
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6.发明授权NEUE MIT CYCLOHEXYLRESTEN SUBSTITUIERTE1,4-BENZOTHIEPIN-1,1 -DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG 有权新配环己SUBSTITUIERTE1,4-苯并硫-1,1-二氧化物的衍生物，用于生产药物含有它们及其用途
公开(公告)号：EP2084143B1
公开(公告)日：2010-01-27
申请号：EP07819435.4
申请日：2007-10-30
发明人： FRICK, Wendelin , GLOMBIK, Heiner , THEIS, Stefan , HEUER, Hubert , SCHAEFER, Hans-Ludwig , KRAMER, Werner
IPC分类号： C07D337/08 , A61K31/08
CPC分类号： C07D337/08
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7.发明公开NEUE 1,4-BENZOTHIEPIN-1,1-DIOXIDDERIVATE MIT VERBESSERTEN EIGENSCHAFTEN, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG 有权具有改进的性质，方法为他们的新的1,4-苯并硫-1,1-二氧化物的衍生物，药物含有它们的及其用途
公开(公告)号：EP2083832A1
公开(公告)日：2009-08-05
申请号：EP07819437.0
申请日：2007-10-30
发明人： GLOMBIK, Heiner , FRICK, Wendelin , THEIS, Stefan , HEUER, Hubert , SCHAEFER, Hans-Ludwig , KRAMER, Werner
IPC分类号： A61K31/7028 , C07H5/06
CPC分类号： C07H5/06 , C07D409/12
摘要： The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. These compounds are suitable, for example, as hypolipidemics.
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8.发明授权
公开(公告)号：EP1756049B1
公开(公告)日：2007-10-31
申请号：EP05747892.7
申请日：2005-05-20
发明人： LINDENSCHMIDT, Andreas , WILL, David, William , JAEHNE, Gerhard , WOLLMANN, Theodor, Andreas , FRICK, Wendelin , JUNKER, Bernd , RIGAL, David , BILLEN, Guenter , JENDRALLA, Heiner
IPC分类号： C07D205/08
CPC分类号： C07D205/08 , A61K31/33
摘要： The invention relates to a method for producing 1,4-diphenyl azetidinone derivatives from suitably protected β-substituted amino amides, in the presence of silylation agents. Said method uses cyclization catalysts that comprise phosphonium ions as the cation of formula (XII), and ions of the following general formulas (a), (b), (c) or (d) as the anion. In said formulas, the symbols, substituents and indices are defined as follows: Z = C=O, C=S, S=O, SO2 or C=NR20; K = O, S, NR21 or CR22R23; L = NR24 or CR25R26; n = 0 or 1; M = O, C=O, NR27 or CR28R29; Q = O, S, NR30, CR31R32, C=O, C=S, S=O, SO2 or C=NR34; R = CR35 or N; T = CR36 or N; U = CR37 or N; V = CR38 or N; the groups R16 to R19 can represent, for example, aryl or (C1-C15) alkyl, aryl(C1-C10)alkene, and the groups R20 to R32 and R34 to R38 can represent in addition H or heteroaryl; R39 and R40 represent, for example (C1-C6) alkyl. The anion can also be R41O-, R42COO- or Cl-, Br- or I- (combined with Ag2O).
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9.发明授权NEUE DIPHENZYLAZETIDINONE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG ZUR BEHANDLUNG VON LIPIDSTOFFWECHSELSTÖRUNGEN 有权新DIPHENZYLAZETIDINONE，方法及其，药品含有它们的它们用于脂质代谢紊乱的治疗
公开(公告)号：EP1345895B1
公开(公告)日：2006-12-27
申请号：EP01271353.3
申请日：2001-12-11
发明人： GLOMBIK, Heiner , KRAMER, Werner , FLOHR, Stefanie , FRICK, Wendelin , HEUER, Hubert , JAEHNE, Gerhard , LINDENSCHMIDT, Andreas , SCHAEFER, Hans-Ludwig
IPC分类号： C07D205/08 , A61K31/395 , A61P3/06
CPC分类号： C07F7/186 , C07D205/08
摘要： The invention relates to the compounds of the formula (I), wherein R1, R2, R3, R4, R5, and R6 have the cited meanings, and to their physiologically acceptable salts. The inventive compounds are suitable, for example, as hypolipidemics.
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10.发明授权DIARYLCYCLOALKYLDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS PPAR-AKTIVATOREN 有权DIARYLCYCLOALKYLDERIVATE，其制造方法及其作为PPAR活化剂
公开(公告)号：EP1425014B1
公开(公告)日：2006-12-13
申请号：EP02797589.5
申请日：2002-08-17
发明人： GLOMBIK,Heiner , FALK, Eugen , FRICK, Wendelin , KEIL, Stefanie , SCHÄFER, Hans-Ludwig , SCHWINK, Lothar , WENDLER, Wolfgang
IPC分类号： A61K31/421 , C07D263/32 , C07D413/12 , A61K31/422 , A61P3/06
CPC分类号： C07D263/32 , C07D413/12
摘要： Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I,in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.
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