公开(公告)号：EP0281822A3

公开(公告)日：1990-03-21

申请号：EP88102491.3

申请日：1988-02-20

申请人： Takeda Chemical Industries, Ltd.

发明人： Senoo, Masaharu ,  Krokawa, Tsutomu ,  Igarashi, Koichi ,  Sasada, Reiko

IPC分类号： C12N15/85 ,  C12P21/02

CPC分类号： G01N33/6887 ,  A61K38/00 ,  C07K14/503 ,  C07K14/55 ,  C07K16/22 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/75

摘要： A mutein of basic fibroblast growth factors (bFGF) possesses fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells and angiogenic activity, has high stability and is low toxicity. And therefore, the present mutein is advantageously used as a healing accelerator for burns etc., a therapeutic drug for thrombosis etc., and a cell cultivation promoter.