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    (20S)-23,23-DIFLUORO-2-METHYLENE-19-NOR-BISHOMOPREGNACALCIFEROL-VITAMIN D ANALOGS
    11.
    发明公开
    (20S)-23,23-DIFLUORO-2-METHYLENE-19-NOR-BISHOMOPREGNACALCIFEROL-VITAMIN D ANALOGS 有权
    （20S）-23,23-二氟-2-亚甲基-19-NOR-双肉豆蔻酰维生素 - 维生素D类似物

    公开(公告)号：EP2240439A1

    公开(公告)日：2010-10-20

    申请号：EP08867840.4

    申请日：2008-12-24

    申请人： Wisconsin Alumni Research Foundation

    发明人： DELUCA, Hector, F. ,  CLAGETT-DAME, Margaret ,  PLUM, Lori, A. ,  BARYCKI, Rafal

    IPC分类号： C07C401/00 ,  A61K31/593 ,  A61P3/14 ,  A61P17/06 ,  A61P35/02 ,  A61P37/06 ,  A61P19/02

    CPC分类号： C07C401/00 ,  C07B2200/07 ,  C07C35/52 ,  C07C49/477 ,  C07C2602/24

    摘要： This invention discloses (20S)-23,23-difIuoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs, and specifically (20S)-23,23-difluoro- 1 α- hydroxy-2-methylene-19-nor-bishomopregnacalciferol, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.

    摘要翻译： 本发明公开了（20S）-23,23-二氟-2-亚甲基-19-去 - 双 - 二氢-β-环糊精 - 维生素D类似物，特别是（20S）-23,23-二氟-1-羟基-2-亚甲基-19-去 - nor-bishomopregnacalcalcacalciferol及其制药用途。 该化合物在阻止未分化细胞的增殖和诱导其向单核细胞的分化方面表现出明显的活性，因此证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病如皱纹，皮肤松弛， 皮肤干燥，皮脂分泌不足。 该化合物如果有钙化活性也很少，因此可用于治疗人的自身免疫性疾病或炎性疾病以及肾性骨营养不良。 该化合物也可用于治疗或预防肥胖症。

    (20R)-23,23-DIFLUORO-2-METHYLENE-19-NOR-BISHOMOPREGNACALCIFEROL-VITAMIN D ANALOGS
    14.
    发明授权
    (20R)-23,23-DIFLUORO-2-METHYLENE-19-NOR-BISHOMOPREGNACALCIFEROL-VITAMIN D ANALOGS 有权
    （20R）-23,23-DIFLUOR -2-亚甲基-19-去 - BISHOMOPREGNACALCIFEROL维生素-D-ANALOGA

    公开(公告)号：EP2237837B1

    公开(公告)日：2012-08-22

    申请号：EP08869002.9

    申请日：2008-12-24

    申请人： Wisconsin Alumni Research Foundation

    发明人： DELUCA, Hector, F. ,  CLAGETT-DAME, Margaret ,  PLUM, Lori, A. ,  BARYCKI, Rafal

    IPC分类号： A61P17/00 ,  A61K31/593 ,  C07C401/00

    CPC分类号： C07D401/00

    摘要： This invention discloses (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs, and specifically (20R)-23,23-difluoro-lα-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.

    2-METHYLENE-18,19-DINOR-1ALFA-HYDROXY-HOMOPREGNACALCIFEROL AND ITS USES
    17.
    发明公开
    2-METHYLENE-18,19-DINOR-1ALFA-HYDROXY-HOMOPREGNACALCIFEROL AND ITS USES 有权
    2-METHYLENE-18,19-DINOR-1ALFA-HYDROXY-HOMOPREGNACALCIFEROL及其用途

    公开(公告)号：EP1817278A2

    公开(公告)日：2007-08-15

    申请号：EP05848578.0

    申请日：2005-11-18

    申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

    发明人： DELUCA, Hector, F. ,  BARYCKI, Rafal ,  PLUM, Lori, A. ,  CLAGETT-DAME, Margaret

    IPC分类号： C07C401/00 ,  A61K31/59 ,  A61P11/06 ,  A61P17/06 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00

    CPC分类号： C07C401/00

    摘要： This invention discloses 2-methylene-18,19-dinor-vitamin D analogs, and specifically 2-methylene-18,19-dinor-1α-hydroxy-homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.

    摘要翻译： 本发明公开了2-亚甲基-18,19-二 - 维生素D类似物，特别是2-亚甲基-18,19-二醇-1α-羟基 - 高级别氢化维生素D及其药物用途。 该化合物在阻止未分化细胞的增殖和诱导其向单核细胞的分化方面表现出明显的活性，因此证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病如皱纹，皮肤松弛， 皮肤干燥，皮脂分泌不足。 该化合物如果有钙化活性也很少，因此可用于治疗人的自身免疫性疾病或炎性疾病以及肾性骨营养不良。 该化合物也可用于治疗或预防肥胖症。