公开(公告)号：EP2925340B1

公开(公告)日：2019-05-08

申请号：EP13857618.6

申请日：2013-11-20

申请人： University Of Cincinnati ,  Abdel-Malek, Zalfa A. ,  Koikov, Leonid ,  Knittel, James J.

发明人： ABDEL-MALEK, Zalfa, A. ,  KOIKOV, Leonid ,  KNITTEL, James, J.

IPC分类号： A61K38/34 ,  A61K38/06 ,  A61K38/07 ,  A61K8/64 ,  A61Q17/04 ,  A61Q19/00 ,  C07K5/097 ,  C07K5/117 ,  A61Q19/04 ,  A61Q19/08 ,  A61K38/00 ,  A61P17/00 ,  A61P35/00

CPC分类号： C07K5/1024 ,  A61K8/06 ,  A61K8/64 ,  A61K9/0014 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/04 ,  A61Q19/08 ,  C07K5/0821

摘要： Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin care compositions including Formula I peptide agonists of MC1R and methods of regulating a skin condition of a mammal that include applying to a treatment surface of the body a safe and effective amount of a skin care composition including a Formula I peptide. The peptides, skin care compositions, and skin care methods described herein are useful in regulating a skin condition of a mammal associated with exposure ultraviolet (UV) radiation, including sunburn, UV sensitivity, photoaging, and skin pigmentation, particularly in the absence of sun exposure.

公开(公告)号：EP3003263B1

公开(公告)日：2018-11-14

申请号：EP14727825.3

申请日：2014-06-03

申请人： Pierre Fabre Dermo-Cosmétique

发明人： BACQUEVILLE, Daniel ,  BOGDANOWICZ, Patrick ,  SAURAT, Jean-Hilaire ,  SORG, Olivier

IPC分类号： A61P35/00 ,  A61P17/00 ,  A61K8/64 ,  A61K8/67 ,  A61K31/11 ,  A61K38/05 ,  A61Q19/08 ,  A61Q19/00 ,  A61K31/7048

CPC分类号： A61K8/64 ,  A61K8/671 ,  A61K8/678 ,  A61K31/11 ,  A61K31/7048 ,  A61K38/05 ,  A61P17/00 ,  A61P35/00 ,  A61Q19/004 ,  A61Q19/08 ,  A61K2300/00

公开(公告)号：EP3393444A1

公开(公告)日：2018-10-31

申请号：EP16812977.3

申请日：2016-12-21

申请人： Laboratoires Expanscience

发明人： LECLERE-BIENFAIT, Sophie ,  BREDIF, Stéphanie

IPC分类号： A61K8/49 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  A61K8/97 ,  A61K36/185 ,  A61P17/00

CPC分类号： A61K8/97 ,  A61K8/498 ,  A61K36/185 ,  A61K2236/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/06 ,  A61Q19/08

摘要： The invention relates to a polyphenolic extract of passion flower seeds, in particular
Passiflora incarnata or
Passiflora edulis seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof.

公开(公告)号：EP2240152B1

公开(公告)日：2018-08-15

申请号：EP09704059.6

申请日：2009-01-12

申请人： Galderma Research & Development

发明人： LOUIS, Fabienne ,  SEGURA, Sandrine ,  WILLCOX, Nathalie

IPC分类号： A61K8/38 ,  A61K8/67 ,  A61K8/73 ,  A61K31/192 ,  A61K31/327 ,  A61K47/36 ,  A61Q7/00 ,  A61Q19/08 ,  A61Q19/00

CPC分类号： A61K47/26 ,  A61K8/38 ,  A61K8/671 ,  A61K8/73 ,  A61K9/0014 ,  A61K31/192 ,  A61K31/327 ,  A61K31/731 ,  A61Q5/008 ,  A61Q7/00 ,  A61Q19/004 ,  A61Q19/008 ,  A61Q19/08

公开(公告)号：EP3349719A1

公开(公告)日：2018-07-25

申请号：EP16847436.9

申请日：2016-09-16

申请人： June Jacobs Laboratories, Llc

发明人： JACOBS, June

IPC分类号： A61K8/30 ,  A61K8/97 ,  A61Q19/08

CPC分类号： A61K8/9789 ,  A61K8/361 ,  A61K8/922 ,  A61K8/97 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/02

摘要： The disclosure provides compositions and methods for the prophylaxis and/or treatment of radiation dermatitis or erythema.

公开(公告)号：EP3116849B1

公开(公告)日：2018-07-25

申请号：EP15720265.6

申请日：2015-03-10

申请人： Giuliani S.p.A.

发明人： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  MARZANI, Barbara ,  BARONI, Sergio ,  PINI, Elena ,  GANDOLFI, Raffaella

IPC分类号： C07C69/587 ,  C07C57/03 ,  A61K8/36 ,  A61Q5/00 ,  A61K45/06 ,  A61K31/19 ,  A61K31/22 ,  A61K31/575 ,  C07C279/14 ,  C07J9/00 ,  A61Q19/00 ,  A61K8/37 ,  A61K8/44 ,  A61Q1/14 ,  A61K8/63 ,  A61Q7/00 ,  A61Q17/04

CPC分类号： C07J9/00 ,  A61K8/361 ,  A61K8/37 ,  A61K8/375 ,  A61K8/44 ,  A61K8/63 ,  A61K45/06 ,  A61K2800/10 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/007 ,  C07C57/03 ,  C07C69/587 ,  C07C279/14

摘要： The invention relates to 2,4,6-octatrienoic acid derivative compounds having general formula (I) (CH3—CH═CH—CH═CH—CH═CH—CO—O—)n—R (I) consisting of esters wherein n=1, 2, 3 and wherein R is selected from alkyl, aryl or cycloalkyl of a polyol, phenol or phenolic acid; or consisting of a salt wherein n=1 and R=arginine, as active ingredients in a pharmaceutical or cosmetic composition having a combined antioxidant activity against free radicals together with an anti-inflammatory action.

公开(公告)号：EP3307754A1

公开(公告)日：2018-04-18

申请号：EP16807940.8

申请日：2016-02-25

申请人： Elysium Health, Inc.

发明人： MARCOTULLI, Eric, Alexander ,  GUARENTE, Leonard, Pershing ,  ALMINANA, Daniel, Antonio ,  BOWEN, Paul, Michael

IPC分类号： C07H19/048 ,  A61K31/09

CPC分类号： A61K31/455 ,  A61K8/368 ,  A61K8/675 ,  A61K9/0053 ,  A61K9/4866 ,  A61K31/09 ,  A61K31/706 ,  A61K2300/00 ,  A61P17/00 ,  A61Q19/004

摘要： Compositions containing a combination of nicotinamide riboside and pterostilbene for treating skin disorders, and methods of treating skin disorders using these compositions and their equivalents are described. The skin disorders that are treated using these compositions or methods include sun exposure-related skin disorders, inflammatory skin disorders, autoimmune disease-related skin disorders and cancer-related skin disorders. In one embodiment, the compositions containing a combination of nicotinamide riboside and pterostilbene are prepared as oral formulations.

公开(公告)号：EP2818543B8

公开(公告)日：2018-03-07

申请号：EP12869142.5

申请日：2012-11-29

申请人： Bloomage Freda Biopharm Co., Ltd.

发明人： GUO, Xueping ,  SHI, Yanli ,  QIAO, Liping ,  FENG, Ning ,  WANG, Guanfeng ,  LI, Haina ,  XUE, Wei ,  WANG, Haiying ,  LUAN,Yihong ,  LIU, Aihua

IPC分类号： C12N1/20 ,  C12N9/26 ,  C12N15/56 ,  C12P19/28 ,  C07K14/32 ,  A61K8/73 ,  A61K31/728 ,  A61P17/02 ,  A61P9/00 ,  A61Q17/00 ,  C12R1/07

CPC分类号： C12N9/2474 ,  A23L33/17 ,  A23V2002/00 ,  A61K8/66 ,  A61K8/735 ,  A61K31/728 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/08 ,  C08B37/0072 ,  C12N9/2408 ,  C12P19/26 ,  C12P19/28 ,  C12R1/07 ,  Y02P20/52

摘要： The present invention provides a bacillus sp. having a deposit access number of CGMCC NO. 5744 and a hyaluronidase produced by the bacillus and the amino acid sequence of the hyaluronidase is shown in SEQ ID NO: 2. The present invention further relates to a process for preparing oligomeric hyaluronic acid or salts thereof or low-molecular-weight hyaluronic acid or salts thereof by using the bacillus or the hyaluronidase produced thereby. The produced oligomeric hyaluronates or low-molecular-weight hyaluronates have advantages such as good transdermal absorption ability, high purity, no cytotoxicity, potent antioxidant ability. The present invention also provides use of the bacillus having a deposit access number of CGMCC NO. 5744, or the hyaluronidase, oligomeric hyaluronates or salts thereof, low-molecular-weight hyaluronates or salts thereof produced by the bacillus in the fields of osmetics, food products and medicines.

公开(公告)号：EP2101727B1

公开(公告)日：2017-11-08

申请号：EP07871755.0

申请日：2007-12-31

申请人： Wisconsin Alumni Research Foundation

发明人： CLAGETT-DAME, Margaret ,  DELUCA, Hector, F. ,  NIEVES, Nirca, J. ,  PLUM, Lori, A. ,  KAISER, Mary, E. ,  BARYCKI, Rafal

IPC分类号： A61K9/08 ,  A61K47/10 ,  A61K31/59 ,  A61P17/06 ,  A61P17/10 ,  A61P35/00 ,  A61P17/00 ,  A61Q19/08 ,  A61Q19/00 ,  A61K8/67 ,  A61K9/48 ,  A61K47/44 ,  A61K31/203

CPC分类号： A61K31/59 ,  A61K8/67 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0095 ,  A61K31/203 ,  A61K47/10 ,  A61K47/44 ,  A61K2800/92 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/08

摘要： Topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 19-nor-26,27-dimethylene-20(S)-2-methylene-1±,25-dihydroxyvitamin D3, 2-methylene-1±,25-dihydroxy-(17E)-17(20)-dehydro-19-nor vitamin D3, 2-methylene-(20R,25S)-19,26-dinor-1±,25-dihydroxyvitamin D3, 2-methylene-23,23-difluoro-1±-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1±-hydroxy-19-nor-bishomopregnancalciferol, (2-(3'hydroxypropyl-1',2'-idene)-19,23,24-trinor-(20S)-1±-hydroxyvitamin D3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and/or a solute thereof.

公开(公告)号：EP2865422B1

公开(公告)日：2017-10-18

申请号：EP14173509.2

申请日：2007-08-31

申请人： Clinuvel Pharmaceuticals Limited

发明人： Wolgen, Philippe

IPC分类号： A61K38/34 ,  A61P17/00 ,  A61P17/16 ,  A61K8/64 ,  A61Q17/04 ,  A61Q19/00

CPC分类号： A61K38/34 ,  A61K8/64 ,  A61Q17/04 ,  A61Q19/004