公开(公告)号：EP1496925A2

公开(公告)日：2005-01-19

申请号：EP03719612.8

申请日：2003-04-08

申请人： ZymoGenetics, Inc.

发明人： CHANDRASEKHER, Yasmin, A. ,  MCKERNAN, Patricia, A.

IPC分类号： A61K38/00

CPC分类号： A61K31/7048 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/555 ,  A61K31/675 ,  A61K31/704 ,  A61K38/14 ,  A61K38/164 ,  A61K38/168 ,  A61K38/20 ,  A61K41/0038 ,  A61K47/642 ,  A61K2300/00

摘要： The present invention relates to the anti-cancer activity of IL-24 polypeptide molecules. IL-24 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-24 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-24 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.

公开(公告)号：EP1606317B1

公开(公告)日：2010-07-28

申请号：EP04749427.3

申请日：2004-03-24

申请人： ZymoGenetics, Inc.

发明人： XU, Wenfeng ,  KINDSVOGEL, Wayne ,  CHANDRASEKHER, Yasmin, A. ,  DILLON, Stacey, R. ,  LEHNER, Joyce, M. ,  SIADAK, Anthony, W. ,  SIVAKUMAR, Pallavur, V. ,  MOORE, Margaret, D.

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/7155 ,  C07K16/244 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/30

摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.

公开(公告)号：EP1606317A2

公开(公告)日：2005-12-21

申请号：EP04749427.3

申请日：2004-03-24

申请人： ZymoGenetics, Inc.

发明人： XU, Wenfeng ,  KINDSVOGEL, Wayne ,  CHANDRASEKHER, Yasmin, A. ,  DILLON, Stacey, R. ,  LEHNER, Joyce, M. ,  SIADAK, Anthony, W. ,  SIVAKUMAR, Pallavur, V. ,  MOORE, Margaret, D.

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/7155 ,  C07K16/244 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/30

摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.

公开(公告)号：EP1606316A2

公开(公告)日：2005-12-21

申请号：EP04758097.2

申请日：2004-03-24

申请人： ZymoGenetics, Inc.

发明人： XU, Wenfeng ,  KINDSVOGEL, Wayne ,  CHANDRASEKHER, Yasmin, A. ,  DILLON, Stacey, R. ,  LEHNER, Joyce, M. ,  SIADAK, Anthony, W. ,  SIVAKUMAR, Pallavur, V. ,  MOORE, Margaret, D.

IPC分类号： C07K16/24

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/7155 ,  C07K16/244 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/30

摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-20 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. The present invention includes anti-IL-20 and anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.

公开(公告)号：EP1531843A1

公开(公告)日：2005-05-25

申请号：EP02805181.1

申请日：2002-12-17

申请人： ZymoGenetics, Inc.

发明人： CHANDRASEKHER, Yasmin, A. ,  MCKERNAN, Patricia, A.

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K45/00

CPC分类号： A61K38/20 ,  A61B18/02 ,  A61B18/12 ,  A61B18/20 ,  A61K38/14 ,  A61K38/212 ,  A61K38/215 ,  A61K45/06 ,  A61K2300/00

摘要： Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus . IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or surgical excision of the involved cells or lesions.

公开(公告)号：EP1496933A2

公开(公告)日：2005-01-19

申请号：EP03719664.9

申请日：2003-04-08

申请人： ZymoGenetics, Inc.

发明人： CHANDRASEKHER, Yasmin, A. ,  MCKERNAN, Patricia, A.

IPC分类号： A61K38/20

CPC分类号： A61K41/0038 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/53 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24 ,  A61K38/14 ,  A61K38/164 ,  A61K38/168 ,  A61K38/20 ,  A61K41/00 ,  A61K47/642 ,  A61K2300/00

摘要： The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes use of IL-19 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.

公开(公告)号：EP1399472A2

公开(公告)日：2004-03-24

申请号：EP02713823.9

申请日：2002-03-07

申请人： ZymoGenetics, Inc.

发明人： CHANDRASEKHER, Yasmin, A. ,  NOVAK, Julia, E. ,  FOSTER, Donald, C. ,  XU, Wenfeng ,  JASPERS, Stephen, R.

IPC分类号： C07K14/00 ,  C07K16/00 ,  C12N15/00

CPC分类号： C07K14/7155 ,  C07K2319/00

摘要： A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

公开(公告)号：EP1351703A2

公开(公告)日：2003-10-15

申请号：EP01970886.6

申请日：2001-09-13

申请人： ZymoGenetics, Inc.

发明人： CHANDRASEKHER, Yasmin, A. ,  JASPERS, Stephen, R.

IPC分类号： A61K38/17

CPC分类号： A61K38/1793 ,  C07K14/7155 ,  C07K2319/30

摘要： A method for treating down-regulating IL-19 or mda7 by administering the soluble IL-20RA/IL-20R heterodimeric receptor.