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1.发明授权ANTI-IL-22RA ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 有权抗IL-22RA抗体及其使用炎症结合对象和方法
公开(公告)号：EP1812476B1
公开(公告)日：2010-07-21
申请号：EP05816060.7
申请日：2005-10-21
申请人： ZymoGenetics, Inc.
发明人： XU, Wenfeng , KINDSVOGEL, Wayne, R. , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
IPC分类号： C07K16/28 , C07K14/715
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
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2.发明授权ANTI-IL-20 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 有权ANTI-IL-20-ANTIKÖRPERUND BINDUNGSPARTNER UND VERFAHREN ZUR ANWENDUNG BEIENTZÜNDUNGEN
公开(公告)号：EP1692180B1
公开(公告)日：2009-11-04
申请号：EP04811735.2
申请日：2004-11-19
申请人： ZymoGenetics, Inc.
发明人： XU, Wenfeng , KINDSVOGEL, Wayne, R. , CHEN, Zhi , HUGHES, Steven, D. , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译： 提供了可以与由选自以下的杂交瘤表达的单克隆抗体竞争与SEQ ID NO：2或3的多肽结合的结合多肽：（a）杂交瘤克隆262.4.1.2.2.1（ATCC [PTA-5350]）; （b）杂交瘤克隆262.5.1.6.4.4（ATCC [PTA-5351]）; 和（c）杂交瘤克隆262.7.1.3.2.4（ATCC [PTA-5352]）。
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公开(公告)号：EP1531843B1
公开(公告)日：2011-08-24
申请号：EP02805181.1
申请日：2002-12-17
申请人： ZymoGenetics, Inc.
CPC分类号： A61K38/20 , A61B18/02 , A61B18/12 , A61B18/20 , A61K38/14 , A61K38/212 , A61K38/215 , A61K45/06 , A61K2300/00
摘要： Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus . IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or surgical excision of the involved cells or lesions.
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4.发明公开ANTI-IL-20 RECEPTOR ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开抗IL-20受体抗体及其使用炎症结合对象和方法
公开(公告)号：EP1697418A2
公开(公告)日：2006-09-06
申请号：EP04811758.4
申请日：2004-11-19
申请人： ZymoGenetics, Inc.
发明人： XU, Wenfeng , KINDSVOGEL, Wayne, R. , CHEN, Zhi , HUGHES, Steven, D. , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 receptor polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 receptor antibodies and binding partners, including anti-IL-20RA, anti-IL-20RB and anti-IL-20RA/IL-20RB antibodies as well as methods for antagonizing IL-20RA and IL-20RB, either individually or together, using such antibodies and binding partners.
摘要翻译： 本发明提供一种结合多肽做可以结合SEQ ID NO：2的多肽竞争：从所述组包括选择2或3与由杂交瘤表达的单克隆抗体：（a）所述的杂交瘤克隆262.4.1.2.2.1（ATCC [PTA-5350]）; （B）的杂交瘤克隆262.5.1.6.4.4（ATCC [PTA-5351]）; 和（c）杂交瘤克隆262.7.1.3.2.4（ATCC [PTA-5352]）。
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公开(公告)号：EP1546358A2
公开(公告)日：2005-06-29
申请号：EP03719461.0
申请日：2003-03-24
申请人： ZymoGenetics, Inc.
CPC分类号： C07K16/244 , A61K39/3955 , A61K2039/505 , C07K2317/34
摘要： The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
摘要翻译： 本发明涉及阻断IL-TIF多肽分子的活性。 IL-TIF是一种参与炎症过程和人类疾病的细胞因子。 本发明包括抗-IL-TIF抗体和结合配偶体，以及在IL-TIF-相关的人类炎性疾病中使用这些抗体和结合配偶体来拮抗IL-TIF的方法，以及公开的其它用途。
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公开(公告)号：EP1492560A2
公开(公告)日：2005-01-05
申请号：EP03719611.0
申请日：2003-04-08
申请人： ZymoGenetics, Inc.
CPC分类号： A61K33/24 , A61K31/196 , A61K31/407 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K38/14 , A61K38/164 , A61K38/168 , A61K38/20 , A61K41/00 , A61K45/06 , A61K47/642 , A61K2300/00
摘要： The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of cervical cancer cells, treating cervical cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
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公开(公告)号：EP1399472B1
公开(公告)日：2009-06-03
申请号：EP02713823.9
申请日：2002-03-07
申请人： ZymoGenetics, Inc.
发明人： CHANDRASEKHER, Yasmin, A. , NOVAK, Julia, E. , FOSTER, Donald, C. , XU, Wenfeng , JASPERS, Stephen, R.
IPC分类号： C07K14/00 , C07K14/715
CPC分类号： C07K14/7155 , C07K2319/00
摘要： A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
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8.发明公开ANTI-IL-22RA ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 有权抗IL-22RA抗体及其使用炎症结合对象和方法
公开(公告)号：EP1812476A1
公开(公告)日：2007-08-01
申请号：EP05816060.7
申请日：2005-10-21
申请人： ZymoGenetics, Inc.
发明人： XU, Wenfeng , KINDSVOGEL, Wayne, R. , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
IPC分类号： C07K16/28 , C07K14/715
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
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9.发明公开ANTI-IL-20 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 有权抗IL-20抗体和结合伴侣AND METHOD FOR USE炎症
公开(公告)号：EP1692180A2
公开(公告)日：2006-08-23
申请号：EP04811735.2
申请日：2004-11-19
申请人： ZymoGenetics, Inc.
发明人： XU, Wenfeng , KINDSVOGEL, Wayne, R. , CHEN, Zhi , HUGHES, Steven, D. , CHANDRASEKHER, Yasmin, A. , DILLON, Stacey, R. , LEHNER, Joyce, M. , SIADAK, Anthony, W. , SIVAKUMAR, Pallavur, V. , MOORE, Margaret, D.
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
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10.发明授权USE OF A POLYPEPTIDE COMPRISING THE EXTRACELLULAR DOMAINS OF IL-20RA AND IL-20RB FOR THE TREATMENT OF INFLAMMATION 有权使用包括IL-20RA和IL-20RB的胞外域含治疗炎症的多肽
公开(公告)号：EP1351703B1
公开(公告)日：2006-07-26
申请号：EP01970886.6
申请日：2001-09-13
申请人： ZymoGenetics, Inc.
CPC分类号： A61K38/1793 , C07K14/7155 , C07K2319/30
摘要： A method for treating down-regulating IL-19 or mda7 by administering the soluble IL-20RA/IL-20R heterodimeric receptor.
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