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79 条记录 (耗时 0.031 秒)

    Antibodies that bind cell-associated CA 125/O722P and methods of use thereof
    17.
    发明授权
    Antibodies that bind cell-associated CA 125/O722P and methods of use thereof 有权

    公开(公告)号：EP2891666B1

    公开(公告)日：2017-06-28

    申请号：EP15155786.5

    申请日：2003-10-15

    申请人： Purdue Pharma L.P.

    发明人： Albone, Earl F. ,  Soltis, Daniel A.

    IPC分类号： C07K16/30 ,  A61K39/395 ,  A61K39/00

    CPC分类号： C07K16/3069 ,  A61K47/6869 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732

    摘要： The present invention provides fusion proteins of antibodies, and antigen-binding fragments of antibodies, that preferentially bind cell-associated CA 125/0772P polypeptides relative to shed CA 125/0772P polypeptides. They comprise a heterologous agent such as a detectable agent or a therapeutic agent. The present disclsoure further provides methods of preventing, managing, treating or ameliorating one or more symptoms associated with a CA 125/0772P-related disorder. In particular, the present disclosure provides methods of preventing, managing, treating, or ameliorating one or more symptoms associated with a cell proliferative disorder, such as cancer, e.g., ovarian cancer. The present disclosure still further provides methods for diagnosing a CA 125/0772P-related disorder or predisposition to developing such a disorder, as well as methods for identifying antibodies, and antigen-binding fragments of antibodies, that preferentially bind cell-associated CA 125/0772P polypeptides relative to shed CA 125/0772P polypeptides.

    AZAMOPHINAN DERIVATIVES AND USE THEREOF
    18.
    发明公开
    AZAMOPHINAN DERIVATIVES AND USE THEREOF 审中-公开
    来自维尔多瓦·达文的AZAMOPHINANDERIVATE

    公开(公告)号：EP3154972A1

    公开(公告)日：2017-04-19

    申请号：EP15807396.5

    申请日：2015-06-12

    申请人： Purdue Pharma L.P.

    发明人： PARK, Jae, Hyun ,  TAFESSE, Laykea

    IPC分类号： C07D471/08

    CPC分类号： C07D471/08 ,  C07D471/18

    摘要： The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R
    1 , R
    2 , R
    3 , R
    4 , Y, and Z are defined as set forth in the specification. The invention is also directed to use of compounds of any one of Formulae I-VIII, and the pharmaceutically acceptable salts and solvates thereof, to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the invention are especially useful for treating pain.

    摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中R1，R2，R3，R4，Y和Z如本说明书所述定义。 本发明还涉及使用式I-VIII中任一项的化合物及其药学上可接受的盐和溶剂合物来治疗对一种或多种阿片受体或作为合成中间体的调节作用的病症。 本发明的某些化合物特别适用于治疗疼痛。

    BENZOMORPHAN ANALOGS AND USE THEREOF
    19.
    发明公开
    BENZOMORPHAN ANALOGS AND USE THEREOF 审中-公开
    BENZOMORPHAN类似物及其用途

    公开(公告)号：EP3139921A1

    公开(公告)日：2017-03-15

    申请号：EP15789868.5

    申请日：2015-05-05

    申请人： Purdue Pharma L.P.

    发明人： TAFESSE, Laykea ,  YAO, Jiangchao ,  YU, Jianming ,  GOEHRING, R. Richard

    IPC分类号： A61K31/439 ,  A61K31/485 ,  A61P29/00

    CPC分类号： C07D221/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

    摘要： The invention provides compounds as represented by Formula I or I' and pharmaceutically acceptable salts, solvates, and diastereomers thereof: Wherein R1, R2, R2a, R3, and R4 are defined in the disclosure. The invention also provides compounds of Formulae II, III, and A-H, and pharmaceutically acceptable salts, solvates, and diastereomers thereof. In certain embodiments, Compounds of the Invention are useful for treating pain, constipation, and other conditions as delineated in the disclosure. Without wishing to be bound by any theory, it is believed that Compounds of the Invention are effective in treating conditions that are modulated by activity of opioid and/or ORL-1 receptors.

    摘要翻译： 本发明提供了由式I或I'表示的化合物及其药学上可接受的盐，溶剂化物和非对映体：其中R1，R2，R2a，R3和R4在本公开中定义。 本发明还提供了式II，III和A-H的化合物及其药学上可接受的盐，溶剂合物和非对映体。 在某些实施方案中，本发明化合物可用于治疗本公开所描述的疼痛，便秘和其它病症。 不希望受任何理论束缚，相信本发明化合物在治疗受阿片样物质和/或ORL-1受体活性调节的病症方面是有效的。

    AZASPIRO[4.5]DECANE DERIVATIVES AND USE THEREOF
    20.
    发明公开
    AZASPIRO[4.5]DECANE DERIVATIVES AND USE THEREOF 审中-公开
    氮杂螺[4.5]癸烷衍生物及其用途

    公开(公告)号：EP3039019A1

    公开(公告)日：2016-07-06

    申请号：EP14839524.7

    申请日：2014-08-11

    申请人： Purdue Pharma L.P.

    发明人： YOUNGMAN, Mark A. ,  TAFESSE, Laykea ,  PARK, Jae Hyun

    IPC分类号： C07D403/04 ,  C07D471/10 ,  C07D471/04 ,  A61K31/506 ,  A61K31/505

    摘要： The invention provides azaspiro[4.5]decane derivatives of Formula (A): and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers thereof, wherein A1, X, A2, Rr, R2′, W1, R3′, R4′, a, and b are defined in the disclosure. The invention also provides compounds of Formulae I, and B-G, and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers thereof. Further, the invention provides use of the compounds of Formulae A-G and I, and the pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers thereof, to treat pain. In certain embodiments, Compounds of the Disclosure are useful for treating a disorder responsive to blockade of one or more sodium channels.