公开(公告)号：EP4367258A1

公开(公告)日：2024-05-15

申请号：EP22744144.1

申请日：2022-07-01

申请人： Unilever IP Holdings B.V. ,  Unilever Global IP Limited

发明人： CHEN, Luonan ,  CHU, Chung-Ching ,  PU, Mingming ,  WANG, Lu ,  XU, Yining

IPC分类号： C12Q1/6809 ,  C12Q1/689 ,  G16B45/00 ,  G16H20/00

CPC分类号： C12Q1/6809 ,  C12Q1/689 ,  C12Q2600/14820130101

公开(公告)号：EP4365564A1

公开(公告)日：2024-05-08

申请号：EP22832113.9

申请日：2022-06-29

申请人： Everlast Healthcare Limited

发明人： ZHAO, Haifeng

IPC分类号： G01M1/38 ,  F16K99/00 ,  G01N35/10

CPC分类号： B01L3/00 ,  C12M1/00 ,  C12M1/36 ,  C12M1/38 ,  C12M1/34 ,  C12N2710/0020130101 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q1/689 ,  C12Q1/70 ,  C12R2001/0120210501 ,  C12R2001/0720210501 ,  C12R2001/12520210501 ,  C12R2001/1920210501 ,  C12R2001/3220210501 ,  C12R2001/3720210501 ,  C12R2001/44520210501 ,  C12R2001/4620210501 ,  C12R2001/6320210501 ,  F16K99/00 ,  G01N35/10 ,  G01M1/14

摘要： A chip device for nucleic acid detection in a sample, comprising a substrate and piston-type containers. The piston-type containers are communicated with each other by means of microfluidic channels; the chip device for nucleic acid detection is further provided with piston valves each located between containers for controlling the fluid communication between the containers communicated with each other; the chip device for nucleic acid detection comprises: a sample receiving module; a sample lysis module; a nucleic acid extraction module, optionally, the nucleic acid extraction module comprising a nucleic acid binding unit, a nucleic acid cleaning unit and a nucleic acid elution unit; and a nucleic acid amplification module. The nucleic acid amplification module comprises multiple amplification area units and an optional pre-amplification area unit. Provided is an instrument used for nucleic acid detection in a sample and using the chip device for nucleic acid detection, in particular, a POCT instrument. Provided is a method for detecting a nucleic acid in a sample by using the chip device or instrument for nucleic acid detection in a sample.

公开(公告)号：EP4363603A1

公开(公告)日：2024-05-08

申请号：EP22834010.5

申请日：2022-06-27

申请人： Sun Genomics Inc.

发明人： JAIN, Suneer ,  PHAN, Joann Lieu ,  NAIR, Divya Balachandran ,  MONTAGNE, Thibaut

IPC分类号： C12Q1/68 ,  G16B20/00 ,  G16B30/00

CPC分类号： Y02A90/10 ,  G16B20/00 ,  C12Q1/689 ,  C12Q1/70 ,  C12Q1/6893 ,  C12Q1/6886 ,  C12Q2600/15820130101

公开(公告)号：EP3405559A1

公开(公告)日：2018-11-28

申请号：EP17742044.5

申请日：2017-01-20

申请人： T2 Biosystems, Inc.

发明人： LOWERY, Thomas, Jay, Jr. ,  PFALLER, Michael, Andy ,  DHANDA, Rahul, Krishan ,  MCDONOUGH, John, J. ,  MAGNUSON, Glenn ,  NEELY, Lori, Anne ,  THOMANN, Ulrich, Hans ,  HARRIS, William, Coulter ,  BLACK, Justin, Layne

IPC分类号： C12M1/00 ,  C12M1/26 ,  C12M1/28 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70

CPC分类号： C12Q1/70 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/689 ,  C12Q1/6893 ,  C12Q2600/158 ,  Y02A50/57

摘要： The invention features methods, panels, cartridges, kits, and systems for rapid and sensitive detection and identification of pathogens and determination of the pathogen's susceptibility to antimicrobial agents for diagnosis and treatment of disease, including bloodstream infection (e.g., bacteremia and fungemia), and sepsis.

公开(公告)号：EP3401396A1

公开(公告)日：2018-11-14

申请号：EP18181011.0

申请日：2013-10-03

申请人： Metabogen AB

发明人： Backhed, Fredrik ,  Karlsson, Fredrik H ,  Nielsen, Jens

IPC分类号： C12N9/02 ,  C12Q1/68 ,  A61K31/00 ,  A61K31/015 ,  A61K35/747 ,  C12Q1/6883 ,  C12Q1/689 ,  G01N33/49 ,  G01N30/00 ,  G06F19/00 ,  G06F19/22 ,  G16H50/30 ,  A61K35/00

CPC分类号： C12Q1/689 ,  A61K31/00 ,  A61K31/015 ,  A61K35/747 ,  A61K2035/115 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/16 ,  G01N30/00 ,  G01N33/49 ,  G01N2407/00 ,  G01N2800/323 ,  G01N2800/50 ,  G06F19/00 ,  G06F19/22 ,  G16H50/30

摘要： The present invention provides the use of beta-carotene in treating or preventing atherosclerosis or atherosclerotic associated disease, wherein the beta-carotene is a probiotic bacteria producing beta-carotene such as Lactobacillus reuteri.

公开(公告)号：EP3400310A1

公开(公告)日：2018-11-14

申请号：EP17709785.4

申请日：2017-01-04

申请人： Wellmicro S.r.l.

发明人： BIAGI, Elena ,  RAMPELLI, Simone ,  TURRONI, Silvia ,  CASTAGNETTI, Andrea ,  CANDELA, Marco

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689

摘要： The present invention relates to a method for determining and/or monitoring the state of health and/or balance of the intestinal microbiota of an individual, said method being characterised by the steps of: typing the bacterial populations present in a sample isolated from an individual, preferably a faecal sample, said populations being representative of the intestinal microbiota of the individual; and measuring a series of indices of the microbiota which provide information on the individual's state of health. The indices are the diversity index, the index of anti-inflammatory and/or immunomodulating potential, the index of association between said intestinal microbiota and at least one pathological condition, and the index of association between said intestinal microbiota and systemic aging. All the indices are calculated compared to a reference microbiota consisting of that of a population of healthy individuals.

公开(公告)号：EP2547782B8

公开(公告)日：2018-11-14

申请号：EP11757080.4

申请日：2011-03-18

申请人： The Translational Genomics Research Institute ,  Arizona Board of Regents on Behalf of Northern Arizona University

发明人： DRIEBE, Elizabeth ,  ENGELTHALER, David ,  BOWERS, Jolene ,  KEIM, Paul

IPC分类号： C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/689 ,  C12Q2600/16

摘要： The present invention provides multiplex assays, methods and kits that may be used to detect and confirm the presence of MRSA in a sample. The methods include real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes. The present invention further comprises assays useful to identify and differentiate MRSA, MSSA, MRSE, MSSE, MRCNS and MSCNS in a sample.

公开(公告)号：EP3392347A1

公开(公告)日：2018-10-24

申请号：EP18174660.3

申请日：2013-03-05

申请人： Life Technologies Corporation

发明人： JI, Yongmei ,  BRZOSKA, Pius ,  BURRELL, Angela ,  O'CONNELL, Caytherine

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q1/6806 ,  C12Q2600/112 ,  C12Q2600/16

摘要： Disclosed are compositions, methods and kits for specific detection, diagnosis and differentiation of Mycobacterium avium subspecies paratuberculosis (MAP).

公开(公告)号：EP3380195A1

公开(公告)日：2018-10-03

申请号：EP17736473.4

申请日：2017-01-06

申请人： Institute for Systems Biology

发明人： PETERSON, Eliza ,  BALIGA, Nitin S.

IPC分类号： A61P31/00 ,  A61P31/04 ,  A61P31/06 ,  A61K31/50 ,  A61K31/713 ,  A61K45/00 ,  C12N15/09

CPC分类号： C12Q1/689 ,  C12Q1/6897 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/4703 ,  G01N2800/12

摘要： Practical assays to identify compounds that overcome the resistance of M. tuberculosis to bedaquiline are based on transcription factors Rv0324 and Rv0880 shown to mediate this resistance.

公开(公告)号：EP2906592B1

公开(公告)日：2018-10-03

申请号：EP13779699.1

申请日：2013-10-08

申请人： Sutro Biopharma, Inc.

发明人： THANOS, Christopher D. ,  MURRAY, Christopher J. ,  YANG, Junhao ,  STEPHENSON, Heather

IPC分类号： C07K14/47 ,  C12N9/50

CPC分类号： C07K14/245 ,  C07K16/00 ,  C07K16/065 ,  C07K16/32 ,  C07K2319/50 ,  C12N9/52 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/686 ,  C12Q1/689 ,  C12Y304/00 ,  C12Y304/21 ,  G01N30/02 ,  G01N30/06

摘要： The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1. The proteins can be modified in an exposed surface motif to incorporate OmpT1 cleavage sites. Also provided are nucleic acids encoding the modified proteins, bacterial cells that express the modified proteins, and cell free synthesis systems containing modified RF1. The disclosure further provides methods for reducing the deleterious activity of a modified protein in a cell free synthesis system by contacting the modified protein with OmpT1. Also provided are methods for reducing RF1 competition at an amber codon in the cell free synthesis system, and methods for expressing a protein in the cell free synthesis system. The modified proteins of the invention can be used to increase the yield of proteins having non-natural amino acids incorporated at an amber codon.