公开(公告)号：EP0081078B1

公开(公告)日：1989-07-12

申请号：EP82109984.3

申请日：1982-10-28

申请人： Temple University of the Commonwealth System of Higher Education

发明人： Zubrzycki, Leonard Joseph

IPC分类号： C12Q1/04 ,  C12Q1/12 ,  C12N1/20

CPC分类号： C12R1/36 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/12 ,  G01N2333/22 ,  Y10S435/871

公开(公告)号：EP0073169A3

公开(公告)日：1984-06-20

申请号：EP82401547

申请日：1982-08-18

申请人： MERCK & CO. INC.

发明人： O'Rourke, Edwards C. ,  Fullerton, Wardle W.

IPC分类号： A61K39/095

CPC分类号： A61K39/095 ,  Y10S435/871

摘要： A vesicular, immunogenic, non-pyrogenic complex is obtained from isolates of N. gonorrhoeae by cultivating N. gonorrhoeae on a suitable nutrient medium; harvesting and centrifuging the cells; extracting the cell pellet with TRITON X-100 at alkaline pH; suspending the solids remaining after extraction in aqueous medium and precipitating in the cold with ethanol.

公开(公告)号：EP0034543A3

公开(公告)日：1982-05-26

申请号：EP81400252

申请日：1981-02-18

申请人： MERCK & CO. INC.

发明人： Karkhanis, Yashwant D.

IPC分类号： A61K39/095

CPC分类号： A61K39/095 ,  Y10S435/871

摘要： Gonococcal antigens are solubilized by a process involving trypsin-digestion.

摘要翻译： 淋球菌抗原通过涉及胰蛋白酶消化的方法溶解。

公开(公告)号：EP0034543A2

公开(公告)日：1981-08-26

申请号：EP81400252.3

申请日：1981-02-18

申请人： Merck & Co., Inc.

发明人： Karkhanis, Yashwant D.

IPC分类号： A61K39/095

CPC分类号： A61K39/095 ,  Y10S435/871

摘要： Gonococcal antigens are solubilized by a process involving trypsin-digestion.

摘要翻译： 淋球菌抗原被涉及胰蛋白酶消化过程中溶解。

公开(公告)号：EP0560969B1

公开(公告)日：1998-12-23

申请号：EP92921587.9

申请日：1992-09-29

申请人： PASTEUR MERIEUX SERUMS ET VACCINS, Société Anonyme :

发明人： QUENTIN-MILLET, Marie-José ,  LISSOLO, Ling

IPC分类号： C07K14/22 ,  A61K39/095

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  Y10S435/871

公开(公告)号：EP0832277A1

公开(公告)日：1998-04-01

申请号：EP96916946.0

申请日：1996-06-03

申请人： Neose Technologies, Inc.

发明人： JOHNSON, Karl, F. ,  ROTH, Stephen ,  BUCZALA, Stephanie, L.

IPC分类号： C12N15 ,  C12N1 ,  C12N9 ,  C12P19 ,  C12R1

CPC分类号： C12P19/18 ,  C12N9/1048 ,  Y10S435/871

摘要： The present invention relates to a method of transferring at least two saccharide units with a polyglycosyltransferase, a polyglycosyltransferase and a gene encoding such a polyglycosyltransferase

公开(公告)号：EP0580829B1

公开(公告)日：1997-11-26

申请号：EP93902023.6

申请日：1993-02-03

申请人： LABORATOIRES OM S.A.

发明人： BAUER, Jacques ,  HIRT, Pierre ,  SCHULTHESS, Adrian

IPC分类号： C12P21/00 ,  A61K35/74

CPC分类号： C07K14/245 ,  A61K38/00 ,  C12P1/00 ,  C12R1/19 ,  Y02A50/473 ,  Y10S435/822 ,  Y10S435/849 ,  Y10S435/851 ,  Y10S435/852 ,  Y10S435/871 ,  Y10S435/885 ,  Y10S435/886

摘要： A modified bacterial protein-based extract comprising a mixture of acidic bacterial polyanions having a molecular weight of 10,000-1,000,000 and an isoelectric point of 2.5-5.5, wherein the sum of the constituent amino acids represents at least 50 wt % of said extract. Said protein extract is prepared by cultivating bacteria in an aqueous medium, subjecting the bacterial suspension to alkaline extraction and purifying the protein extract. Alkaline extraction is performed in the presence of a dilute aqueous source of OH- ions and at a pH of 11-13, with the pH decrease during said extraction being no greater than 0.4. The resulting protein extract may be used as an active ingredient in a pharmaceutical composition.

公开(公告)号：EP0702794A1

公开(公告)日：1996-03-27

申请号：EP94918799.0

申请日：1994-05-27

申请人： BOEHRINGER MANNHEIM ITALIA S.P.A.

发明人： GATTI, Guido, Carlo ,  ARCIONI, Laura

IPC分类号： C07K14 ,  G01N33

CPC分类号： G01N33/571 ,  C07K14/22 ,  C07K14/295 ,  C07K14/30 ,  G01N33/56911 ,  Y10S435/87 ,  Y10S435/871 ,  Y10S435/961 ,  Y10S435/975 ,  Y10S436/808 ,  Y10T436/25125

摘要： The present invention concerns a method and an analytical device for the simultaneous detection of Chlamydia trachomatis (CT), Neisseria gonorrheae (NG) and Mycoplasma (M) from a single specimen.

公开(公告)号：EP0325045B1

公开(公告)日：1995-02-08

申请号：EP88312056.0

申请日：1988-12-20

申请人： SYNTEX (U.S.A.) INC.

发明人： Milburn, Gary Lee ,  Houts, Thomas Michael ,  Rabbie, Judith

IPC分类号： G01N33/543 ,  G01N33/569

CPC分类号： G01N33/54306 ,  G01N33/56911 ,  G01N33/571 ,  Y10S435/871 ,  Y10S436/824 ,  Y10S436/828

公开(公告)号：EP0363090A3

公开(公告)日：1991-07-17

申请号：EP89309943.2

申请日：1989-09-29

申请人： Johnson & Johnson Clinical Diagnostics, Inc.

发明人： Mauck, John Charles, c/o EASTMAN KODAK Co.

IPC分类号： G01N33/569 ,  G01N33/545

CPC分类号： G01N33/56927 ,  G01N33/545 ,  G01N33/571 ,  Y10S435/871

摘要： Antigens from chlamydial or gonococcal organisms in specimens containing whole blood, mucus or components thereof can be rapidly and sensitively determined using a polyamide microporous membrane which is coated with a surfactant. This determina­tion is accomplished by contacting extracted antigen with the coated polyamide microporous membrane which is substantially free of any particulate matter. The membrane has an average pore size of from 1 to 10 µmeter. Within 10 minutes of that contacting, antigen bound to the coated membrane is contacted with chlamydial or gonococcal antibody, respectively, so as to form an immunological complex on the membrane. The presence of the complex on the membrane in then determined as a measure of the amount of chlamydial or gonococcal antigen present in the specimen.