公开(公告)号：EP3623444A1

公开(公告)日：2020-03-18

申请号：EP19206006.9

申请日：2004-06-01

申请人： UDC Ireland Limited

发明人： NII, Kazumi ,  WATANABE, Kousuke ,  IGARASHI, Tatsuya ,  ICHIJIMA, Seiji ,  ISE, Toshihiro

IPC分类号： C09K11/06 ,  C07F15/00 ,  C07D213/53 ,  C07D213/74 ,  C07D471/04 ,  C07D207/20 ,  C07D213/22 ,  H01L51/00 ,  H01L51/50 ,  H01L51/52 ,  C07C251/24 ,  C07D239/48

摘要： An organic electroluminescent device, comprising a pair of electrodes and at least one organic layer including a luminescent layer between the pair of electrodes, wherein at least one layer between the pair of electrodes comprises at least one metal complex represented by formula (1):

wherein
M 11 represents a metal ion;
L 11 , L 12 , L 13 , L 14 , and L 15 each represent a ligand to coordinate to M 11 ;
Y 11 , Y 12 , and Y 13 each represent a linking group, a single bond, or a double bond;
a bond between L 11 and Y 12 , a bond between Y 12 and L 12 , a bond between L 12 and Y 11 , a bond between Y 11 and L 13 , a bond between L 13 and Y 13 , and a bond between Y 13 and L 14 each represent a single bond, or a double bond;
n 11 represents 0 to 4,
excluding metal complexes having no carbon-metal bond.

公开(公告)号：EP3597630A1

公开(公告)日：2020-01-22

申请号：EP18760784.1

申请日：2018-02-23

申请人： Tokyo Institute of Technology

发明人： YAMAMOTO, Kimihisa ,  TSUKAMOTO, Takamasa ,  KAMBE, Tetsuya ,  HARUTA, Naoki ,  IMAOKA, Takane

IPC分类号： C07C251/24 ,  C08G73/00 ,  C07F1/12 ,  C07F5/00 ,  C07F7/22 ,  C07F9/90 ,  C07F9/94 ,  C07F15/00 ,  C07F15/02

摘要： Provided are a multiple-metal salt assembly of dendrimer in which multiple-metal salt compounds with a number of, for example four or more types, particularly five or more types of multiple metals can be assembled for each of parts with different environments so that, particularly, the total metal atom number becomes less than 60, a method for producing the same, and a method for producing subnano metal particles including the multiple-metal salt assembly of the dendrimer.
Four or more types of multiple-metal salt compounds with multiple metal species are assembled for each of parts with different environments of dendrimer whose core is a group expressed by a following Formula (I):
[Chem. 1]

        -(X) n C(Ph) 4-n -     (I)

(in which n number of Xs independently represent a divalent group corresponding to a residue of a six-membered ring aromatic heterocyclic compound including, as a hetero atom, at least one selected from nitrogen, phosphorus, and arsenic, a derivative thereof, or a benzene derivative including an electron-donating functional group, Ph represents a phenylene group, and n represents an integer of 1 to 3).

公开(公告)号：EP2738158B1

公开(公告)日：2019-04-24

申请号：EP12800466.0

申请日：2012-05-10

申请人： IHI Corporation ,  Ishikawa, Yoshihiro

发明人： ISHIKAWA, Yoshihiro ,  EGUCHI, Haruki

IPC分类号： A61K31/555 ,  A61K31/295 ,  C07F15/02 ,  C07C251/24 ,  C07F11/00 ,  C07F13/00 ,  A61K9/00 ,  A61K9/06 ,  A61P35/00 ,  A61P23/02 ,  A61K47/54 ,  A61K47/55 ,  A61K47/61 ,  A61K47/62 ,  A61K47/64

公开(公告)号：EP2907818B1

公开(公告)日：2018-08-15

申请号：EP13846717.0

申请日：2013-10-08

申请人： Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

发明人： TAKENAKA, Hiroshi ,  OHTA, Yoichiro ,  TAGUCHI, Yusuke ,  UEDA, Sayuri ,  ISHINO, Yuko ,  NAKASHIMA, Hideki ,  UEHARA, Kohki ,  KIRIHATA, Mitsunori

IPC分类号： C07F5/04 ,  C07C229/36 ,  C07F5/02 ,  C07B59/00 ,  C07C271/22 ,  C07C251/24

CPC分类号： C07F5/025 ,  C07B59/001 ,  C07C229/08 ,  C07C229/36 ,  C07C251/24 ,  C07C271/22 ,  C07F5/027 ,  C07F5/04 ,  Y02P20/55

摘要： Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18 F-2-fluoro-4-borono-L-phenylalanine ( 18 F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BR 3 R 4 , BX 3 - or BX 3 - M + (wherein X represents a halogen atom, and M + represents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R 1 represents a hydrogen atom or a protecting group PG1; R 2 represents a hydrogen atom or a protecting group PG2; R 3 and R 4 independently represent OH, or R 3 , R 4 and B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO 2 , NH 2 , Sn(R 6 ) 3 , N=N-NR 7 R 8 , OSO 2 R 9 , NR 10 R 11 , a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18 F-labeled BPA.

公开(公告)号：EP3049468B1

公开(公告)日：2018-06-06

申请号：EP14780734.1

申请日：2014-09-23

申请人： Milliken & Company

发明人： DOTSON, Darin L. ,  COOLEY, Mary Angela

IPC分类号： C08K5/17 ,  C07C233/64 ,  C07C233/81 ,  C07C251/24

CPC分类号： C08K5/29 ,  C07C233/64 ,  C07C233/81 ,  C07C251/24 ,  C08K5/0083 ,  C08K5/17 ,  C08L23/06 ,  C08L23/02

摘要： The invention provides a compound conforming to the structure of Formula (CXX) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (CXX) as a nucleating agent.

公开(公告)号：EP3257842A1

公开(公告)日：2017-12-20

申请号：EP17181175.5

申请日：2008-12-01

申请人： Newron Pharmaceuticals S.p.A.

发明人： BARBANTI, Elena ,  FARAVELLI, Laura ,  SALVATI, Patricia ,  CANEVOTTI, Renato ,  PONZINI, Francesco

IPC分类号： C07C251/24 ,  A61K31/165 ,  A61P25/00 ,  A61K31/197 ,  A61K31/198 ,  A61K45/06

摘要： A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides, and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight.
The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to a reduction reaction with a reducing agent selected from sodium borohydride and potassium borohydride in an appropriate amount of an organic solvent selected from C 1 -C 5 lower alkanols, allowing the formation and presence during a substantial position of the reduction reaction course of a suspension of the Schiff base into the saturated solution of the Schiff base into the same organic solvent.

摘要翻译： 一种获得具有高纯度的治疗活性的2- [4-（3-和2-（氟苄氧基）苄基氨基]丙酰胺及其与可药用酸形成的盐的方法，特别是二苄基衍生物杂质含量低于0.03％ 通过使席夫碱中间体2- [4-（3-和2-氟苄氧基）亚苄基氨基]丙酰胺与选自硼氢化钠和钾的还原剂进行还原反应来进行该方法 硼氢化物在合适量的选自C 1 -C 5低级链烷醇的有机溶剂中反应，允许在希夫碱在希夫碱的饱和溶液的悬浮液的还原反应过程的实质位置形成和存在于相同的有机 溶剂。

公开(公告)号：EP3143022A1

公开(公告)日：2017-03-22

申请号：EP15725202.4

申请日：2015-05-15

申请人： Life Technologies Corporation

发明人： GEE, Kyle ,  KANG, Hee Chol ,  ZHOU, Wenjun ,  DUBBELS, Bradley ,  OLSZOWY, Michael ,  O'GRADY, Michael

IPC分类号： C07D471/04 ,  C07C251/24

CPC分类号： G01N33/5005 ,  C07C309/61 ,  C07C2603/24 ,  C07D471/04 ,  C07K16/2812 ,  C09B11/28 ,  G01N33/5014 ,  G01N33/5044

摘要： Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.

摘要翻译： 本文描述了荧光化合物和方法并且包含这些化合物。 本文公开的化合物是卡比洛啉试剂，其在UV / VIS光谱的红色部分发荧光并且提供明亮的荧光强度，均匀的细胞染色，以及在活细胞内的良好保留以及对细胞的低毒性。

公开(公告)号：EP3126325A1

公开(公告)日：2017-02-08

申请号：EP14888552.8

申请日：2014-12-09

申请人： ExxonMobil Chemical Patents Inc. ,  Ramot at Tel-Aviv University Ltd.

发明人： KOL, Moshe ,  HOLTCAMP, Matthew W. ,  PRESS, Konstantin ,  STOPPER, Ayellet

IPC分类号： C07C251/24

CPC分类号： C08F110/06 ,  C07F7/00 ,  C07F7/003 ,  C07F7/28 ,  C08F4/60189 ,  C08F4/64189 ,  C08F4/659 ,  C08F2500/03 ,  C08F2500/15 ,  C08F2500/02 ,  C08F2500/04

摘要： A phenylene-bridged Salalen catalyst, a catalyst system comprising an activator and the phenylene-bridged Salalen catalyst, a process comprising contacting one or more olefins with the catalyst system, and polymers produced by the process are disclosed herein.

摘要翻译： 亚苯基桥联的Salalen催化剂，包含活化剂和亚苯基桥联的Salalen催化剂的催化剂体系，包括使一种或多种烯烃与催化剂体系接触的方法，以及由该方法产生的聚合物在本文中公开。

公开(公告)号：EP2582710B1

公开(公告)日：2016-08-10

申请号：EP11736169.1

申请日：2011-06-16

申请人： Ramot at Tel Aviv University, Ltd.

发明人： KOL, Moshe ,  PRESS, Konstantin ,  COHEN, Ad

IPC分类号： C07F7/00 ,  C07C251/24 ,  C07D207/09 ,  C07C249/02 ,  C08F12/08 ,  C08F110/02 ,  C08F110/06 ,  C08F110/14 ,  C07F7/28 ,  C08F210/16 ,  C08F4/76 ,  C08F10/00

CPC分类号： C07C251/24 ,  C07C249/02 ,  C07C2603/74 ,  C07D207/09 ,  C07F7/00 ,  C07F7/28 ,  C08F4/76 ,  C08F10/00 ,  C08F12/08 ,  C08F110/02 ,  C08F110/06 ,  C08F110/14 ,  C08F210/16 ,  C08F4/64189 ,  C08F2500/20 ,  C08F210/14

公开(公告)号：EP3049468A1

公开(公告)日：2016-08-03

申请号：EP14780734.1

申请日：2014-09-23

申请人： Milliken & Company

发明人： DOTSON, Darin L. ,  COOLEY, Mary Angela

IPC分类号： C08K5/17 ,  C07C233/64 ,  C07C233/81 ,  C07C251/24

CPC分类号： C08K5/29 ,  C07C233/64 ,  C07C233/81 ,  C07C251/24 ,  C08K5/0083 ,  C08K5/17 ,  C08L23/06 ,  C08L23/02

摘要： The invention provides a compound conforming to the structure of Formula (CXX) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (CXX) as a nucleating agent.

摘要翻译： 本发明提供符合式（CXX）结构的化合物。本发明还提供一种包含聚烯烃聚合物和符合式（CXX）结构的化合物作为成核剂的热塑性聚合物组合物。